ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PIK3C3
Symbol Alias	Vps34
Approved Name	phosphoinositide-3-kinase, class 3
Location	18q12.3
Position	chr18:39535171-39667794, +
External Links	HGNC: 8974 Entrez Gene: 5289 Ensembl: ENSG00000078142 UCSC: uc002lap.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q11.2-12.3	chr18:19000000-43500000	1 (1/0/0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048015	phosphatidylinositol-mediated signaling	Biological Process		16
GO:0050708	regulation of protein secretion	Biological Process		2
GO:0045022	early endosome to late endosome transport	Biological Process	IMP[14617358]	3
GO:0045087	innate immune response	Biological Process		54
GO:0043201	response to leucine	Biological Process		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0030496	midbody	Cellular Component		14
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	Biological Process	TAS[7628435]	2
GO:0016303	1-phosphatidylinositol-3-kinase activity	Molecular Function		3
GO:0016485	protein processing	Biological Process		8
GO:0007049	cell cycle	Biological Process		31
GO:0008286	insulin receptor signaling pathway	Biological Process		32
GO:0006661	phosphatidylinositol biosynthetic process	Biological Process		12
GO:0007032	endosome organization	Biological Process		7
GO:0000910	cytokinesis	Biological Process		15
GO:0000045	autophagic vacuole assembly	Biological Process		3
GO:0005515	protein binding	Molecular Function		910
GO:0004672	protein kinase activity	Molecular Function		27
GO:0005770	late endosome	Cellular Component	IDA[14617358]	14
GO:0005524	ATP binding	Molecular Function		228
GO:0006644	phospholipid metabolic process	Biological Process		59
GO:0005829	cytosol	Cellular Component		447

Gene related KEGG pathways (count: 6)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05152	Tuberculosis	30	Tuberculosis, or TB, is an infectious disease caused by Myco...... Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection. More...
hsa01100	Metabolic pathways	237
hsa00562	Inositol phosphate metabolism	14
hsa04070	Phosphatidylinositol signaling system	19
hsa04145	Phagosome	32	Phagocytosis is the process of taking in relatively large pa...... Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes. More...
hsa04140	Regulation of autophagy	6

Genes shared at least 5 GO terms with PIK3C3 (count: 15)

Gene Symbol	Pathway Count	Pathway List
PIK3CG	9	innate immune response; small molecule metabolic process; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol biosynthetic process; protein binding; protein kinase activity; ATP binding; phospholipid metabolic process; cytosol;
PI4KA	7	phosphatidylinositol-mediated signaling; small molecule metabolic process; phosphatidylinositol biosynthetic process; protein binding; ATP binding; phospholipid metabolic process; cytosol;
PIK3R1	7	phosphatidylinositol-mediated signaling; small molecule metabolic process; insulin receptor signaling pathway; phosphatidylinositol biosynthetic process; protein binding; phospholipid metabolic process; cytosol;
MAPK1	7	innate immune response; cell cycle; insulin receptor signaling pathway; protein binding; late endosome; ATP binding; cytosol;
MAPK3	7	innate immune response; cell cycle; insulin receptor signaling pathway; protein binding; late endosome; ATP binding; cytosol;
PRKD1	6	innate immune response; small molecule metabolic process; protein binding; ATP binding; phospholipid metabolic process; cytosol;
PLK1	6	midbody; cytokinesis; protein binding; protein kinase activity; ATP binding; cytosol;
MAPK7	5	innate immune response; cell cycle; protein binding; ATP binding; cytosol;
RIPK3	5	innate immune response; protein binding; protein kinase activity; ATP binding; cytosol;
SYK	5	innate immune response; protein binding; protein kinase activity; ATP binding; cytosol;
INPPL1	5	small molecule metabolic process; phosphatidylinositol biosynthetic process; protein binding; phospholipid metabolic process; cytosol;
MTMR2	5	small molecule metabolic process; phosphatidylinositol biosynthetic process; protein binding; phospholipid metabolic process; cytosol;
PI4K2B	5	small molecule metabolic process; phosphatidylinositol biosynthetic process; ATP binding; phospholipid metabolic process; cytosol;
KIF23	5	midbody; cytokinesis; protein binding; ATP binding; cytosol;
PRKAA1	5	insulin receptor signaling pathway; protein binding; protein kinase activity; ATP binding; cytosol;

Genes shared at least 2 KEGG pathways with PIK3C3 (count: 29)

Gene Symbol	Pathway Count	Pathway List
ATP6V0A2	3	Tuberculosis; Metabolic pathways; Phagosome;
ATP6V0D2	3	Tuberculosis; Metabolic pathways; Phagosome;
TCIRG1	3	Tuberculosis; Metabolic pathways; Phagosome;
CDIPT	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPP5A	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
INPPL1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
IPPK	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4K2B	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PI4KA	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB2	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCB3	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCD4	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCE1	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
PLCG2	3	Metabolic pathways; Inositol phosphate metabolism; Phosphatidylinositol signaling system;
CORO1A	2	Tuberculosis; Phagosome;
FCGR2A	2	Tuberculosis; Phagosome;
FCGR2B	2	Tuberculosis; Phagosome;
FCGR2C	2	Tuberculosis; Phagosome;
FCGR3A	2	Tuberculosis; Phagosome;
FCGR3B	2	Tuberculosis; Phagosome;
HLA-DRB1	2	Tuberculosis; Phagosome;
TLR4	2	Tuberculosis; Phagosome;
ATP6V1C2	2	Metabolic pathways; Phagosome;
ATP6V1F	2	Metabolic pathways; Phagosome;
ATP6V1G1	2	Metabolic pathways; Phagosome;
DGKH	2	Metabolic pathways; Phosphatidylinositol signaling system;
NOS1	2	Metabolic pathways; Phagosome;
PIK3CG	2	Inositol phosphate metabolism; Phosphatidylinositol signaling system;

View in gBrowse

Region: chr18:39535171..39667794 View in gBrowse