ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PLK1
Previous Symbol	PLK
Approved Name	polo-like kinase 1
Previous Name	polo-like kinase (Drosophila)
Location	16p
Position	chr16:23690143-23701688, +
External Links	HGNC: 9077 Entrez Gene: 5347 Ensembl: ENSG00000166851 UCSC: uc002dlz.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16p12.3-12.2	chr16:16800000-24200000	1 (1/0/0)

Gene related GO terms (count: 50)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 50)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030496	midbody	Cellular Component	IDA[19468300]	14
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		14
GO:0031572	G2/M transition DNA damage checkpoint	Biological Process	IDA[18662541]	7
GO:0031648	protein destabilization	Biological Process	IDA[16885022]	2
GO:0010997	anaphase-promoting complex binding	Molecular Function	IPI[18662541]	1
GO:0016567	protein ubiquitination	Biological Process	IDA[16885022]	41
GO:0018105	peptidyl-serine phosphorylation	Biological Process	IDA[16885022]	12
GO:0019901	protein kinase binding	Molecular Function		51
GO:0007346	regulation of mitotic cell cycle	Biological Process	IMP[17495026]	6
GO:0008017	microtubule binding	Molecular Function	IDA[12939256]	32
GO:0008283	cell proliferation	Biological Process	TAS[8127874]	60
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	Biological Process		4
GO:0006468	protein phosphorylation	Biological Process	IDA[19468300]	53
GO:0007067	mitosis	Biological Process	IDA[18615013]; IMP[18477460]	39
GO:0007091	mitotic metaphase/anaphase transition	Biological Process		4
GO:0007092	activation of mitotic anaphase-promoting complex activity	Biological Process	IDA[15148369]	1
GO:0005819	spindle	Cellular Component	IDA[12939256]	29
GO:0005813	centrosome	Cellular Component		71
GO:0005876	spindle microtubule	Cellular Component		9
GO:0005829	cytosol	Cellular Component		447
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function	IPI[17146433]	910
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component	IDA[18615013]	770
GO:0001578	microtubule bundle formation	Biological Process	IDA[12939256]	8
GO:0000942	condensed nuclear chromosome outer kinetochore	Cellular Component	IDA[18195732]	1
GO:0004674	protein serine/threonine kinase activity	Molecular Function	IDA[19468302]	61
GO:0004672	protein kinase activity	Molecular Function	IDA[17146433]	27
GO:0000776	kinetochore	Cellular Component		15
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0000922	spindle pole	Cellular Component		22
GO:0000910	cytokinesis	Biological Process	IDA[19468302]; IMP[12939256]	15
GO:0090007	regulation of mitotic anaphase	Biological Process		1
GO:0071168	protein localization to chromatin	Biological Process		1
GO:0051726	regulation of cell cycle	Biological Process		8
GO:0051443	positive regulation of ubiquitin-protein ligase activity	Biological Process	IMP[19473992]	1
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0051297	centrosome organization	Biological Process	IMP[8991084]	5
GO:0051233	spindle midzone	Cellular Component		3
GO:0045862	positive regulation of proteolysis	Biological Process	IDA[16885022]	3
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	Biological Process		6
GO:0043393	regulation of protein binding	Biological Process		4
GO:0043066	negative regulation of apoptotic process	Biological Process	IMP[18174154]	77
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	Biological Process	IMP[19473992]	5
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process	IDA[19160488]	29
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IMP[18174154]	78
GO:0000236	mitotic prometaphase	Biological Process		17
GO:0000087	M phase of mitotic cell cycle	Biological Process		19
GO:0000088	mitotic prophase	Biological Process		1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...
hsa04114	Oocyte meiosis	22	During meiosis, a single round of DNA replication is followe...... During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle. More...
hsa04914	Progesterone-mediated oocyte maturation	13	Xenopus oocytes are naturally arrested at G2 of meiosis I. E...... Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP. More...

Genes shared at least 5 GO terms with PLK1 (count: 124)

Gene Symbol	Pathway Count	Pathway List
KIF23	12	midbody; microtubule binding; spindle; centrosome; cytosol; ATP binding; protein binding; nucleoplasm; nucleus; mitotic cell cycle; cytokinesis; M phase of mitotic cell cycle;
NEK6	12	G2/M transition DNA damage checkpoint; peptidyl-serine phosphorylation; protein kinase binding; regulation of mitotic cell cycle; protein phosphorylation; mitosis; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity; spindle pole; cytokinesis;
GSK3B	11	peptidyl-serine phosphorylation; protein kinase binding; positive regulation of peptidyl-threonine phosphorylation; protein phosphorylation; centrosome; cytosol; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity; negative regulation of apoptotic process;
CLASP1	11	microtubule binding; centrosome; spindle microtubule; cytosol; protein binding; microtubule bundle formation; kinetochore; mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
APC	10	protein kinase binding; microtubule binding; mitotic metaphase/anaphase transition; centrosome; cytosol; protein binding; nucleus; kinetochore; negative regulation of cyclin-dependent protein kinase activity; negative regulation of apoptotic process;
CDK5RAP2	10	protein kinase binding; microtubule binding; centrosome; cytosol; protein binding; microtubule bundle formation; mitotic cell cycle; spindle pole; centrosome organization; G2/M transition of mitotic cell cycle;
LATS1	10	protein kinase binding; protein phosphorylation; mitosis; cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; spindle pole; negative regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle;
PAFAH1B1	10	microtubule binding; centrosome; cytosol; protein binding; nucleus; kinetochore; mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
KIF2C	10	cell proliferation; mitosis; cytosol; ATP binding; protein binding; nucleus; kinetochore; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
CSNK1E	10	protein phosphorylation; cytosol; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity; protein kinase activity; mitotic cell cycle; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; G2/M transition of mitotic cell cycle;
SMC3	10	mitosis; mitotic metaphase/anaphase transition; ATP binding; protein binding; nucleoplasm; nucleus; mitotic cell cycle; spindle pole; mitotic prometaphase; M phase of mitotic cell cycle;
AURKC	9	midbody; protein phosphorylation; spindle; ATP binding; nucleus; protein serine/threonine kinase activity; protein kinase activity; cytokinesis; spindle midzone;
DCTN3	9	midbody; mitosis; spindle; centrosome; cytosol; protein binding; mitotic cell cycle; cytokinesis; G2/M transition of mitotic cell cycle;
INCENP	9	midbody; spindle; cytosol; protein binding; kinetochore; mitotic cell cycle; cytokinesis; mitotic prometaphase; M phase of mitotic cell cycle;
ANAPC4	9	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitosis; cytosol; nucleoplasm; nucleus; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; G2/M transition of mitotic cell cycle;
PSMC3	9	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; ATP binding; protein binding; nucleoplasm; nucleus; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
CHEK1	9	G2/M transition DNA damage checkpoint; centrosome; cytosol; ATP binding; protein binding; nucleoplasm; nucleus; protein serine/threonine kinase activity; G2/M transition of mitotic cell cycle;
MAPK1	9	peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; spindle; cytosol; ATP binding; protein binding; nucleoplasm; nucleus; protein serine/threonine kinase activity;
CDC25B	9	protein kinase binding; protein phosphorylation; mitosis; centrosome; cytosol; nucleoplasm; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle;
NDE1	9	microtubule binding; centrosome; cytosol; protein binding; kinetochore; mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
MAPRE1	9	cell proliferation; spindle; centrosome; cytosol; protein binding; mitotic cell cycle; G2/M transition of mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
LATS2	9	protein phosphorylation; mitosis; cytosol; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity; spindle pole; negative regulation of cyclin-dependent protein kinase activity;
SMC1A	9	mitotic metaphase/anaphase transition; ATP binding; protein binding; nucleoplasm; nucleus; kinetochore; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
NUMA1	9	spindle; spindle microtubule; cytosol; protein binding; nucleoplasm; nucleus; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle;
CKAP5	9	centrosome; cytosol; protein binding; mitotic cell cycle; spindle pole; centrosome organization; G2/M transition of mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
PSRC1	8	midbody; microtubule binding; spindle; spindle microtubule; cytosol; protein binding; microtubule bundle formation; spindle pole;
CDC26	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitosis; cytosol; protein binding; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
SKP2	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell proliferation; cytosol; protein binding; nucleoplasm; mitotic cell cycle; regulation of cell cycle; G2/M transition of mitotic cell cycle;
UBB	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; protein binding; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter;
UBC	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; protein binding; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter;
ATM	8	G2/M transition DNA damage checkpoint; peptidyl-serine phosphorylation; spindle; ATP binding; protein binding; nucleoplasm; protein serine/threonine kinase activity; negative regulation of apoptotic process;
ILK	8	peptidyl-serine phosphorylation; protein kinase binding; cell proliferation; protein phosphorylation; cytosol; ATP binding; protein binding; protein serine/threonine kinase activity;
TGFBR1	8	peptidyl-serine phosphorylation; protein phosphorylation; ATP binding; protein binding; protein serine/threonine kinase activity; protein kinase activity; regulation of protein binding; negative regulation of apoptotic process;
KIF11	8	protein kinase binding; microtubule binding; mitosis; spindle; spindle microtubule; cytosol; ATP binding; spindle pole;
PRC1	8	protein kinase binding; microtubule binding; spindle; spindle microtubule; protein binding; nucleus; spindle pole; cytokinesis;
ROCK2	8	protein phosphorylation; centrosome; cytosol; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity; cytokinesis;
XPO1	8	cytosol; protein binding; nucleoplasm; kinetochore; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; mitotic prometaphase; M phase of mitotic cell cycle;
ZW10	8	cytosol; protein binding; nucleus; kinetochore; mitotic cell cycle; spindle pole; mitotic prometaphase; M phase of mitotic cell cycle;
BIRC6	7	midbody; protein ubiquitination; protein phosphorylation; mitosis; protein binding; spindle pole; negative regulation of apoptotic process;
PSMB7	7	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; protein binding; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSMD5	7	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; protein binding; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSMD7	7	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; protein binding; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
MAPK7	7	peptidyl-serine phosphorylation; cytosol; ATP binding; protein binding; nucleoplasm; nucleus; negative regulation of apoptotic process;
PRKD1	7	peptidyl-serine phosphorylation; cell proliferation; cytosol; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity;
SMG1	7	peptidyl-serine phosphorylation; cytosol; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity; protein kinase activity;
CCND1	7	protein kinase binding; cytosol; protein binding; nucleoplasm; nucleus; protein kinase activity; mitotic cell cycle;
PAK1	7	protein kinase binding; protein phosphorylation; cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; protein kinase activity;
SYK	7	protein kinase binding; cell proliferation; protein phosphorylation; cytosol; ATP binding; protein binding; protein kinase activity;
CEP57	7	microtubule binding; centrosome; cytosol; protein binding; nucleus; mitotic cell cycle; G2/M transition of mitotic cell cycle;
MARK4	7	microtubule binding; protein phosphorylation; centrosome; ATP binding; protein binding; microtubule bundle formation; protein serine/threonine kinase activity;
MAP3K11	7	cell proliferation; protein phosphorylation; centrosome; ATP binding; protein binding; protein serine/threonine kinase activity; protein kinase activity;
PRKAA1	7	protein phosphorylation; cytosol; ATP binding; protein binding; nucleus; protein kinase activity; negative regulation of apoptotic process;
CEP164	7	mitosis; centrosome; cytosol; protein binding; nucleus; mitotic cell cycle; G2/M transition of mitotic cell cycle;
TUBGCP2	7	centrosome; cytosol; protein binding; nucleus; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle;
PIK3C3	6	midbody; cytosol; ATP binding; protein binding; protein kinase activity; cytokinesis;
PSMA8	6	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; nucleus; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSME1	6	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSME2	6	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cytosol; nucleoplasm; mitotic cell cycle; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PTTG1	6	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; mitosis; cytosol; protein binding; nucleus; mitotic cell cycle;
SNCA	6	protein destabilization; microtubule binding; cytosol; protein binding; nucleus; negative regulation of apoptotic process;
NEDD4L	6	protein ubiquitination; cytosol; protein binding; nucleoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter;
RFWD2	6	protein ubiquitination; centrosome; cytosol; protein binding; nucleoplasm; nucleus;
CENPJ	6	protein kinase binding; centrosome; cytosol; protein binding; mitotic cell cycle; G2/M transition of mitotic cell cycle;
CEP250	6	protein kinase binding; centrosome; cytosol; protein binding; mitotic cell cycle; G2/M transition of mitotic cell cycle;
GATA6	6	protein kinase binding; protein binding; nucleoplasm; nucleus; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter;
MAP2K3	6	protein kinase binding; cytosol; ATP binding; protein binding; nucleoplasm; protein serine/threonine kinase activity;
RELA	6	protein kinase binding; cytosol; protein binding; nucleoplasm; nucleus; negative regulation of apoptotic process;
ARHGEF2	6	microtubule binding; mitosis; spindle; cytosol; protein binding; negative regulation of apoptotic process;
MAP1S	6	microtubule binding; spindle; cytosol; protein binding; nucleus; microtubule bundle formation;
TUBGCP5	6	microtubule binding; centrosome; cytosol; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle;
TUBGCP6	6	microtubule binding; centrosome; cytosol; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle;
UXT	6	microtubule binding; centrosome; protein binding; nucleus; centrosome organization; negative regulation of transcription from RNA polymerase II promoter;
KDM1A	6	cell proliferation; protein binding; nucleoplasm; nucleus; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter;
XRCC5	6	cell proliferation; ATP binding; protein binding; nucleoplasm; nucleus; negative regulation of apoptotic process;
YAP1	6	cell proliferation; cytosol; protein binding; nucleoplasm; nucleus; negative regulation of apoptotic process;
IRF7	6	protein phosphorylation; cytosol; protein binding; nucleoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter;
MAPK3	6	protein phosphorylation; cytosol; ATP binding; protein binding; nucleoplasm; nucleus;
PRKCB	6	protein phosphorylation; cytosol; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity;
KIF22	6	mitosis; spindle; cytosol; ATP binding; nucleus; kinetochore;
TNFAIP3	6	centrosome; cytosol; protein binding; nucleus; negative regulation of cyclin-dependent protein kinase activity; negative regulation of apoptotic process;
CENPC1	6	cytosol; nucleus; kinetochore; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
MEN1	6	cytosol; protein binding; nucleoplasm; nucleus; negative regulation of cyclin-dependent protein kinase activity; negative regulation of transcription from RNA polymerase II promoter;
PIK3CG	6	cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; protein kinase activity; negative regulation of apoptotic process;
MED1	6	protein binding; nucleoplasm; nucleus; regulation of cell cycle; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter;
HSPA5	5	midbody; ATP binding; protein binding; nucleus; negative regulation of apoptotic process;
KATNB1	5	midbody; microtubule binding; mitosis; centrosome; spindle pole;
RBBP8	5	G2/M transition DNA damage checkpoint; mitosis; protein binding; nucleus; negative regulation of transcription from RNA polymerase II promoter;
CBL	5	protein ubiquitination; cytosol; protein binding; nucleus; negative regulation of apoptotic process;
CUL5	5	protein ubiquitination; cell proliferation; cytosol; protein binding; nucleus;
MALT1	5	protein ubiquitination; cytosol; protein binding; nucleus; negative regulation of apoptotic process;
TRIM32	5	protein ubiquitination; protein binding; nucleus; positive regulation of proteolysis; negative regulation of apoptotic process;
ADRBK1	5	peptidyl-serine phosphorylation; cytosol; ATP binding; protein binding; protein kinase activity;
CAMK2D	5	peptidyl-serine phosphorylation; protein phosphorylation; cytosol; ATP binding; nucleoplasm;
MAML1	5	protein kinase binding; protein phosphorylation; protein binding; nucleoplasm; nucleus;
PRKAG2	5	protein kinase binding; positive regulation of peptidyl-threonine phosphorylation; cytosol; ATP binding; nucleoplasm;
SQSTM1	5	protein kinase binding; cytosol; protein binding; nucleoplasm; protein serine/threonine kinase activity;
AATF	5	regulation of mitotic cell cycle; centrosome; protein binding; nucleus; negative regulation of apoptotic process;
CRYAB	5	microtubule binding; cytosol; protein binding; nucleus; negative regulation of apoptotic process;
DAB2	5	cell proliferation; protein binding; nucleus; negative regulation of apoptotic process; positive regulation of proteasomal ubiquitin-dependent protein catabolic process;
ERBB2	5	cell proliferation; protein phosphorylation; ATP binding; protein binding; nucleus;
PAK7	5	cell proliferation; ATP binding; nucleus; protein serine/threonine kinase activity; negative regulation of apoptotic process;
TXN	5	cell proliferation; cytosol; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter;
CDC42BPG	5	protein phosphorylation; centrosome; ATP binding; protein binding; protein serine/threonine kinase activity;
CFL1	5	protein phosphorylation; protein binding; nucleus; cytokinesis; negative regulation of apoptotic process;
MARK2	5	protein phosphorylation; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity;
RPS6KA4	5	protein phosphorylation; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity;
SIK2	5	protein phosphorylation; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity;
STK36	5	protein phosphorylation; ATP binding; protein binding; nucleus; protein serine/threonine kinase activity;
CDC45	5	centrosome; protein binding; nucleoplasm; nucleus; mitotic cell cycle;
CEP76	5	centrosome; cytosol; protein binding; mitotic cell cycle; G2/M transition of mitotic cell cycle;
CNTRL	5	centrosome; cytosol; protein binding; mitotic cell cycle; G2/M transition of mitotic cell cycle;
DHX9	5	centrosome; ATP binding; protein binding; nucleoplasm; nucleus;
TFAP2A	5	centrosome; protein binding; nucleus; negative regulation of apoptotic process; negative regulation of transcription from RNA polymerase II promoter;
TUBG1	5	centrosome; cytosol; protein binding; mitotic cell cycle; G2/M transition of mitotic cell cycle;
TUBGCP4	5	centrosome; cytosol; mitotic cell cycle; spindle pole; G2/M transition of mitotic cell cycle;
NCOR1	5	spindle microtubule; protein binding; nucleoplasm; nucleus; negative regulation of transcription from RNA polymerase II promoter;
BIRC2	5	cytosol; protein binding; nucleus; regulation of cell cycle; negative regulation of apoptotic process;
CDT1	5	cytosol; protein binding; nucleoplasm; nucleus; mitotic cell cycle;
CENPL	5	cytosol; nucleus; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
CENPN	5	cytosol; nucleoplasm; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
CENPP	5	cytosol; nucleoplasm; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
CLASP2	5	cytosol; protein binding; mitotic cell cycle; mitotic prometaphase; M phase of mitotic cell cycle;
HSPA8	5	cytosol; ATP binding; protein binding; nucleus; regulation of cell cycle;
RIPK3	5	cytosol; ATP binding; protein binding; protein serine/threonine kinase activity; protein kinase activity;

Genes shared at least 2 KEGG pathways with PLK1 (count: 14)

Gene Symbol	Pathway Count	Pathway List
ANAPC4	3	Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation;
CDC26	3	Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation;
CDC25B	2	Cell cycle; Progesterone-mediated oocyte maturation;
PTTG1	2	Cell cycle; Oocyte meiosis;
SMC1A	2	Cell cycle; Oocyte meiosis;
SMC3	2	Cell cycle; Oocyte meiosis;
YWHAH	2	Cell cycle; Oocyte meiosis;
YWHAQ	2	Cell cycle; Oocyte meiosis;
ADCY4	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
INS	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
MAPK1	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
MAPK3	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
PGR	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;
SPDYC	2	Oocyte meiosis; Progesterone-mediated oocyte maturation;

View in gBrowse

Region: chr16:23690143..23701688 View in gBrowse