ADHDgene Database

Gene Report

Basic Info

Approved Symbol	PPIH
Symbol Alias	USA-CYP, CYP-20, SnuCyp-20, CYPH, MGC5016
Approved Name	peptidylprolyl isomerase H (cyclophilin H)
Previous Name	peptidyl prolyl isomerase H (cyclophilin H)
Name Alias	USA-CyP SnuCyp-20, "cyclophilin H", "U-snRNP-associated cyclophilin SunCyp-20", "small nuclear ribonucleoprotein particle-specific cyclophilin H", "rotamase H", "peptidyl-prolyl cis-trans isomerase H", "PPIase h"
Location	1p34.1
Position	chr1:43124048-43142429, +
External Links	HGNC: 14651 Entrez Gene: 10465 Ensembl: ENSG00000171960 UCSC: uc001chq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005681	spliceosomal complex	Cellular Component	IC[9570313]	51

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[9570313]	910
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	Molecular Function	IDA[9570313]	2
GO:0005737	cytoplasm	Cellular Component	IDA[9570313]	690
GO:0000413	protein peptidyl-prolyl isomerization	Biological Process	IDA[9570313]	2
GO:0000398	mRNA splicing, via spliceosome	Biological Process	IC[9570313]	54
GO:0045070	positive regulation of viral genome replication	Biological Process	IMP[19932913]	1
GO:0043021	ribonucleoprotein complex binding	Molecular Function	IDA[9570313]	4
GO:0071001	U4/U6 snRNP	Cellular Component	IDA[9570313]	3
GO:0046540	U4/U6 x U5 tri-snRNP complex	Cellular Component	IDA[9570313]	3
GO:0006461	protein complex assembly	Biological Process	TAS[9570313]	28
GO:0006457	protein folding	Biological Process		28
GO:0016607	nuclear speck	Cellular Component	IDA[9570313]	34
GO:0016018	cyclosporin A binding	Molecular Function	TAS[9570313]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03040	Spliceosome	47	After transcription, eukaryotic mRNA precursors contain prot...... After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified. More...

Genes shared at least 5 GO terms with PPIH (count: 4)

Gene Symbol	Pathway Count	Pathway List
PRPF6	7	protein binding; spliceosomal complex; mRNA splicing, via spliceosome; ribonucleoprotein complex binding; U4/U6 snRNP; U4/U6 x U5 tri-snRNP complex; nuclear speck;
CD2BP2	6	protein binding; cytoplasm; mRNA splicing, via spliceosome; ribonucleoprotein complex binding; U4/U6 x U5 tri-snRNP complex; nuclear speck;
EFTUD2	5	protein binding; cytoplasm; spliceosomal complex; mRNA splicing, via spliceosome; nuclear speck;
PRPF4	5	protein binding; spliceosomal complex; mRNA splicing, via spliceosome; U4/U6 snRNP; nuclear speck;

Genes shared at least 2 KEGG pathways with PPIH (count: 0)

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Region: chr1:43124048..43142429 View in gBrowse