Gene Report
Basic Info
Approved Symbol |
PTPRN2
|
Symbol Alias |
KIAA0387, phogrin, ICAAR, IA-2beta |
Approved Name |
protein tyrosine phosphatase, receptor type, N polypeptide 2 |
Name Alias |
IAR PTPRP |
Location |
7q36 |
Position |
chr7:157331750-158380482, - |
External Links |
HGNC: 9677
Entrez Gene: 5799
Ensembl: ENSG00000155093
UCSC: uc003wno.2
|
No. of Studies |
1 (significant: 0; non-significant: 0; trend: 1) |
Source |
Literature-origin; Mapped by CNV |
Gene related studies (count: 1)
Gene related SNPs (count: 0)
Gene related CNVs (count: 1)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 8)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04940 |
Type I diabetes mellitus |
6 |
Type I diabetes mellitus is a disease that results from auto......
Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).
More...
|
Genes shared at least 5 GO terms with PTPRN2 (count: 0)
Genes shared at least 2 KEGG pathways with PTPRN2 (count: 0)
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