ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RIPK3
Symbol Alias	RIP3
Approved Name	receptor-interacting serine-threonine kinase 3
Location	14q12
Position	chr14:24805227-24809242, -
External Links	HGNC: 10021 Entrez Gene: 11035 Ensembl: ENSG00000129465 UCSC: uc001wpb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0060545	positive regulation of necroptosis	Biological Process		1
GO:0005886	plasma membrane	Cellular Component		772
GO:0097190	apoptotic signaling pathway	Biological Process	TAS[10339433]	6
GO:0006464	cellular protein modification process	Biological Process	TAS[10358032]	13
GO:0006917	induction of apoptosis	Biological Process		31
GO:0007165	signal transduction	Biological Process	TAS[10339433]	171
GO:0045087	innate immune response	Biological Process		54
GO:0007249	I-kappaB kinase/NF-kappaB cascade	Biological Process		5
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:0032147	activation of protein kinase activity	Biological Process		5
GO:0051260	protein homooligomerization	Biological Process		34
GO:0032481	positive regulation of type I interferon production	Biological Process		2
GO:0051291	protein heterooligomerization	Biological Process		10
GO:0042802	identical protein binding	Molecular Function		70
GO:0003713	transcription coactivator activity	Molecular Function	TAS[10339433]	52
GO:0004672	protein kinase activity	Molecular Function	TAS[10358032]	27
GO:0004674	protein serine/threonine kinase activity	Molecular Function	TAS[10339433]	61
GO:0004704	NF-kappaB-inducing kinase activity	Molecular Function		2
GO:0005515	protein binding	Molecular Function		910
GO:0005524	ATP binding	Molecular Function		228
GO:0005739	mitochondrion	Cellular Component		183
GO:0005829	cytosol	Cellular Component		447

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04623	Cytosolic DNA-sensing pathway	9	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell. More...

Genes shared at least 5 GO terms with RIPK3 (count: 42)

Gene Symbol	Pathway Count	Pathway List
PRKD1	9	plasma membrane; signal transduction; innate immune response; positive regulation of NF-kappaB transcription factor activity; identical protein binding; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
MAPK1	8	induction of apoptosis; signal transduction; innate immune response; protein serine/threonine kinase activity; protein binding; ATP binding; mitochondrion; cytosol;
PAK1	7	plasma membrane; identical protein binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
PIK3CG	7	plasma membrane; innate immune response; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
PRKCB	7	plasma membrane; signal transduction; positive regulation of NF-kappaB transcription factor activity; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
TGFBR1	7	plasma membrane; induction of apoptosis; signal transduction; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
PYCARD	7	induction of apoptosis; signal transduction; innate immune response; positive regulation of NF-kappaB transcription factor activity; protein binding; mitochondrion; cytosol;
ADRBK1	6	plasma membrane; signal transduction; protein kinase activity; protein binding; ATP binding; cytosol;
ILK	6	plasma membrane; protein heterooligomerization; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
SYK	6	plasma membrane; innate immune response; protein kinase activity; protein binding; ATP binding; cytosol;
UBB	6	plasma membrane; innate immune response; I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein binding; cytosol;
UBC	6	plasma membrane; innate immune response; I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein binding; cytosol;
FADD	6	apoptotic signaling pathway; innate immune response; protein heterooligomerization; identical protein binding; protein binding; cytosol;
MAP3K5	6	apoptotic signaling pathway; innate immune response; identical protein binding; protein kinase activity; protein binding; ATP binding;
CSNK1E	6	signal transduction; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
MAP2K3	6	signal transduction; innate immune response; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
PRKAA1	6	signal transduction; protein heterooligomerization; protein kinase activity; protein binding; ATP binding; cytosol;
RELA	6	innate immune response; positive regulation of NF-kappaB transcription factor activity; positive regulation of type I interferon production; identical protein binding; protein binding; cytosol;
AIP	5	plasma membrane; signal transduction; transcription coactivator activity; protein binding; cytosol;
CRYAB	5	plasma membrane; protein homooligomerization; protein binding; mitochondrion; cytosol;
ERBB2	5	plasma membrane; signal transduction; identical protein binding; protein binding; ATP binding;
GSK3B	5	plasma membrane; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
MALT1	5	plasma membrane; innate immune response; positive regulation of NF-kappaB transcription factor activity; protein binding; cytosol;
PRKG1	5	plasma membrane; signal transduction; protein binding; ATP binding; cytosol;
ROCK2	5	plasma membrane; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
SNCA	5	plasma membrane; identical protein binding; protein binding; mitochondrion; cytosol;
TIRAP	5	plasma membrane; innate immune response; I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein binding;
TLR4	5	plasma membrane; innate immune response; I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; protein binding;
WWOX	5	plasma membrane; induction of apoptosis; protein binding; mitochondrion; cytosol;
FASTK	5	apoptotic signaling pathway; protein serine/threonine kinase activity; protein binding; ATP binding; mitochondrion;
CASP1	5	induction of apoptosis; signal transduction; innate immune response; protein binding; cytosol;
MAPK7	5	signal transduction; innate immune response; protein binding; ATP binding; cytosol;
P2RX6	5	signal transduction; protein homooligomerization; protein heterooligomerization; identical protein binding; ATP binding;
TXN	5	signal transduction; innate immune response; protein binding; mitochondrion; cytosol;
MAPK3	5	innate immune response; protein binding; ATP binding; mitochondrion; cytosol;
MAPK9	5	innate immune response; protein binding; ATP binding; mitochondrion; cytosol;
PIK3C3	5	innate immune response; protein kinase activity; protein binding; ATP binding; cytosol;
GLUL	5	protein homooligomerization; identical protein binding; ATP binding; mitochondrion; cytosol;
SQSTM1	5	protein heterooligomerization; identical protein binding; protein serine/threonine kinase activity; protein binding; cytosol;
MAP3K11	5	identical protein binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding;
PLK1	5	protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;
SMG1	5	protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; cytosol;

Genes shared at least 2 KEGG pathways with RIPK3 (count: 0)

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Region: chr14:24805227..24809242 View in gBrowse