ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SCARB1
Previous Symbol	CD36L1
Symbol Alias	SRB1, CLA-1, CLA1, SR-BI
Approved Name	scavenger receptor class B, member 1
Previous Name	CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
Location	12q24.32
Position	chr12:125262174-125348519, -
External Links	HGNC: 1664 Entrez Gene: 949 Ensembl: ENSG00000073060 UCSC: uc001ugm.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_26	chr12:122465458-124605386 (NCBI36 / hg18)	2139929	12q24.31-12q24.32	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 47)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 47)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005901	caveola	Cellular Component	TAS[12651854]	12
GO:0006629	lipid metabolic process	Biological Process		51
GO:0006702	androgen biosynthetic process	Biological Process		4
GO:0006707	cholesterol catabolic process	Biological Process		1
GO:0005545	1-phosphatidylinositol binding	Molecular Function	TAS[9211901]	6
GO:0005737	cytoplasm	Cellular Component		690
GO:0005886	plasma membrane	Cellular Component	IDA[9211901]	772
GO:0005887	integral to plasma membrane	Cellular Component		220
GO:0001786	phosphatidylserine binding	Molecular Function		3
GO:0001875	lipopolysaccharide receptor activity	Molecular Function	IDA[12651854]	2
GO:0001935	endothelial cell proliferation	Biological Process		2
GO:0005215	transporter activity	Molecular Function	TAS[9211901]	41
GO:0001530	lipopolysaccharide binding	Molecular Function	IDA[12651854]	2
GO:0032497	detection of lipopolysaccharide	Biological Process	IDA[12651854]	2
GO:0031663	lipopolysaccharide-mediated signaling pathway	Biological Process	IDA[12651854]	5
GO:0034185	apolipoprotein binding	Molecular Function	IPI[10764676]	5
GO:0033344	cholesterol efflux	Biological Process	ISS[14718538]	8
GO:0019048	virus-host interaction	Biological Process		54
GO:0015920	lipopolysaccharide transport	Biological Process	IDA[12651854]	1
GO:0031528	microvillus membrane	Cellular Component		2
GO:0030169	low-density lipoprotein particle binding	Molecular Function	IDA[9211901]	5
GO:0010886	positive regulation of cholesterol storage	Biological Process	IDA[9211901]	3
GO:0010867	positive regulation of triglyceride biosynthetic process	Biological Process		2
GO:0015914	phospholipid transport	Biological Process		1
GO:0010899	regulation of phosphatidylcholine catabolic process	Biological Process		1
GO:0008035	high-density lipoprotein particle binding	Molecular Function		2
GO:0007155	cell adhesion	Biological Process		86
GO:0010595	positive regulation of endothelial cell migration	Biological Process	TAS[17574123]	7
GO:0009986	cell surface	Cellular Component		70
GO:0051856	adhesion to symbiont	Biological Process	IMP[19087225]	1
GO:0070328	triglyceride homeostasis	Biological Process		7
GO:0050764	regulation of phagocytosis	Biological Process	IC[9211901]	2
GO:0051000	positive regulation of nitric-oxide synthase activity	Biological Process	IDA[11792700]	3
GO:0043691	reverse cholesterol transport	Biological Process	IEP[9211901]	7
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0043534	blood vessel endothelial cell migration	Biological Process		2
GO:0043654	recognition of apoptotic cell	Biological Process	IDA[9211901]	1
GO:0042632	cholesterol homeostasis	Biological Process		18
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0042060	wound healing	Biological Process	TAS[17574123]	13
GO:0042157	lipoprotein metabolic process	Biological Process		11
GO:0034383	low-density lipoprotein particle clearance	Biological Process		3
GO:0034384	high-density lipoprotein particle clearance	Biological Process	IDA[9211901]	3
GO:0034186	apolipoprotein A-I binding	Molecular Function	IPI[10764676]	2
GO:0034375	high-density lipoprotein particle remodeling	Biological Process		5
GO:0070508	cholesterol import	Biological Process		2
GO:0070506	high-density lipoprotein particle receptor activity	Molecular Function	IDA[9211901]	1

Gene related KEGG pathways (count: 5)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04145	Phagosome	32	Phagocytosis is the process of taking in relatively large pa...... Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes. More...
hsa04975	Fat digestion and absorption	19	Fat is an important energy source from food. More than 95% o...... Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph. More...
hsa05160	Hepatitis C	17	Hepatitis C virus (HCV) is a major cause of chronic liver di...... Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis. More...
hsa04977	Vitamin digestion and absorption	7	Vitamins are a diverse and chemically unrelated group of org...... Vitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactions. Because humans and other mammals cannot synthesize these compounds (except for some synthesis of niacin), they must obtain them from exogenous sources via intestinal absorption. Vitamins are classified based on their solubility in water or fat. Most of the water-soluble vitamins are transported across the small intestinal membrane by carrier-mediated mechanisms, but vitamin B12, cobalamin, is transported by a receptor-mediated mechanism. Intestinal absorption of fat-soluble vitamins requires all of the processes needed for fat absorption. After digestion, these vitamins and the products of pancreatic hydrolysis of triglycerides (TG) are emulsified by bile salts to form mixed micelles which are taken up by intestinal enterocytes and incorporated into chylomicrons (CM). CM are then secreted into the lymphatic system, and finally moves into the plasma. More...
hsa04976	Bile secretion	13	Bile is a vital secretion, essential for digestion and absor...... Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates. More...

Genes shared at least 5 GO terms with SCARB1 (count: 17)

Gene Symbol	Pathway Count	Pathway List
APOA1	14	lipid metabolic process; plasma membrane; endothelial cell proliferation; cholesterol efflux; high-density lipoprotein particle binding; triglyceride homeostasis; reverse cholesterol transport; small molecule metabolic process; blood vessel endothelial cell migration; cholesterol homeostasis; lipoprotein metabolic process; high-density lipoprotein particle clearance; high-density lipoprotein particle remodeling; cholesterol import;
ABCA1	10	lipid metabolic process; plasma membrane; integral to plasma membrane; apolipoprotein binding; cholesterol efflux; reverse cholesterol transport; small molecule metabolic process; cholesterol homeostasis; lipoprotein metabolic process; apolipoprotein A-I binding;
APOA4	9	lipid metabolic process; cholesterol efflux; cell surface; reverse cholesterol transport; small molecule metabolic process; cholesterol homeostasis; protein homodimerization activity; lipoprotein metabolic process; high-density lipoprotein particle remodeling;
APOC2	9	lipid metabolic process; cholesterol efflux; triglyceride homeostasis; reverse cholesterol transport; small molecule metabolic process; cholesterol homeostasis; protein homodimerization activity; lipoprotein metabolic process; high-density lipoprotein particle clearance;
APOC3	8	lipid metabolic process; cholesterol efflux; triglyceride homeostasis; reverse cholesterol transport; small molecule metabolic process; cholesterol homeostasis; lipoprotein metabolic process; high-density lipoprotein particle remodeling;
LPL	8	lipid metabolic process; plasma membrane; apolipoprotein binding; positive regulation of cholesterol storage; cell surface; triglyceride homeostasis; small molecule metabolic process; lipoprotein metabolic process;
TLR4	7	cytoplasm; plasma membrane; integral to plasma membrane; lipopolysaccharide receptor activity; lipopolysaccharide binding; detection of lipopolysaccharide; lipopolysaccharide-mediated signaling pathway;
CUBN	6	lipid metabolic process; plasma membrane; transporter activity; small molecule metabolic process; protein homodimerization activity; lipoprotein metabolic process;
STAB2	6	cytoplasm; plasma membrane; integral to plasma membrane; low-density lipoprotein particle binding; cell adhesion; small molecule metabolic process;
ADAM17	5	cytoplasm; plasma membrane; integral to plasma membrane; cell adhesion; cell surface;
ADRA2A	5	cytoplasm; plasma membrane; integral to plasma membrane; small molecule metabolic process; protein homodimerization activity;
ADRA2C	5	cytoplasm; plasma membrane; integral to plasma membrane; small molecule metabolic process; protein homodimerization activity;
CCR5	5	cytoplasm; plasma membrane; integral to plasma membrane; virus-host interaction; cell surface;
FZD4	5	cytoplasm; plasma membrane; integral to plasma membrane; cell surface; protein homodimerization activity;
PRKD1	5	cytoplasm; plasma membrane; integral to plasma membrane; positive regulation of endothelial cell migration; small molecule metabolic process;
ACHE	5	plasma membrane; cell adhesion; cell surface; small molecule metabolic process; protein homodimerization activity;
AMBP	5	plasma membrane; virus-host interaction; cell adhesion; cell surface; protein homodimerization activity;

Genes shared at least 2 KEGG pathways with SCARB1 (count: 3)

Gene Symbol	Pathway Count	Pathway List
APOA1	2	Fat digestion and absorption; Vitamin digestion and absorption;
APOA4	2	Fat digestion and absorption; Vitamin digestion and absorption;
PNLIP	2	Fat digestion and absorption; Vitamin digestion and absorption;

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Region: chr12:125262174..125348519 View in gBrowse