ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SHMT1
Symbol Alias	CSHMT, SHMT, MGC15229, MGC24556
Approved Name	serine hydroxymethyltransferase 1 (soluble)
Name Alias	cytoplasmic serine hydroxymethyltransferase, "14 kDa protein"
Location	17p11.2
Position	chr17:18231187-18266856, -
External Links	HGNC: 10850 Entrez Gene: 6470 Ensembl: ENSG00000176974 UCSC: uc002gta.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0034641	cellular nitrogen compound metabolic process	Biological Process		30
GO:0030170	pyridoxal phosphate binding	Molecular Function	IDA[17482557]	12
GO:0042803	protein homodimerization activity	Molecular Function	IDA[9753690]	113
GO:0035999	tetrahydrofolate interconversion	Biological Process		4
GO:0009113	purine nucleobase biosynthetic process	Biological Process	IDA[11516159]	1
GO:0008732	L-allo-threonine aldolase activity	Molecular Function		2
GO:0019264	glycine biosynthetic process from serine	Biological Process		2
GO:0016597	amino acid binding	Molecular Function		8
GO:0051289	protein homotetramerization	Biological Process		9
GO:0045329	carnitine biosynthetic process	Biological Process		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0051262	protein tetramerization	Biological Process	IDA[9753690]	6
GO:0046655	folic acid metabolic process	Biological Process	IDA[11278996]	4
GO:0005737	cytoplasm	Cellular Component		690
GO:0005739	mitochondrion	Cellular Component		183
GO:0004372	glycine hydroxymethyltransferase activity	Molecular Function	IDA[8505317]	2
GO:0005634	nucleus	Cellular Component		770
GO:0006766	vitamin metabolic process	Biological Process		13
GO:0006767	water-soluble vitamin metabolic process	Biological Process		13
GO:0005829	cytosol	Cellular Component	IDA[17482557]	447
GO:0006565	L-serine catabolic process	Biological Process	IDA[17482557]	1

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00670	One carbon pool by folate	6
hsa00260	Glycine, serine and threonine metabolism	6	Serine is derived from 3-phospho-D-glycerate, an intermediat...... Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018]. More...
hsa00460	Cyanoamino acid metabolism	4

Genes shared at least 5 GO terms with SHMT1 (count: 17)

Gene Symbol	Pathway Count	Pathway List
SHMT2	8	pyridoxal phosphate binding; tetrahydrofolate interconversion; L-allo-threonine aldolase activity; glycine biosynthetic process from serine; amino acid binding; protein homotetramerization; mitochondrion; glycine hydroxymethyltransferase activity;
TH	7	cellular nitrogen compound metabolic process; amino acid binding; small molecule metabolic process; cytoplasm; mitochondrion; nucleus; cytosol;
MTMR2	6	protein homodimerization activity; small molecule metabolic process; protein tetramerization; cytoplasm; nucleus; cytosol;
MTHFR	6	tetrahydrofolate interconversion; small molecule metabolic process; folic acid metabolic process; vitamin metabolic process; water-soluble vitamin metabolic process; cytosol;
NAPRT1	6	small molecule metabolic process; cytoplasm; nucleus; vitamin metabolic process; water-soluble vitamin metabolic process; cytosol;
DDC	5	cellular nitrogen compound metabolic process; pyridoxal phosphate binding; amino acid binding; small molecule metabolic process; cytosol;
PSMC3	5	cellular nitrogen compound metabolic process; small molecule metabolic process; cytoplasm; nucleus; cytosol;
MOCOS	5	pyridoxal phosphate binding; small molecule metabolic process; vitamin metabolic process; water-soluble vitamin metabolic process; cytosol;
CRYAB	5	protein homodimerization activity; cytoplasm; mitochondrion; nucleus; cytosol;
PTS	5	protein homodimerization activity; small molecule metabolic process; cytoplasm; mitochondrion; cytosol;
PYCARD	5	protein homodimerization activity; cytoplasm; mitochondrion; nucleus; cytosol;
QPRT	5	protein homodimerization activity; small molecule metabolic process; vitamin metabolic process; water-soluble vitamin metabolic process; cytosol;
KARS	5	amino acid binding; cytoplasm; mitochondrion; nucleus; cytosol;
DHFRP1	5	small molecule metabolic process; folic acid metabolic process; vitamin metabolic process; water-soluble vitamin metabolic process; cytosol;
GSTP1	5	small molecule metabolic process; cytoplasm; mitochondrion; nucleus; cytosol;
NMNAT2	5	small molecule metabolic process; cytoplasm; nucleus; vitamin metabolic process; water-soluble vitamin metabolic process;
NMNAT3	5	small molecule metabolic process; mitochondrion; vitamin metabolic process; water-soluble vitamin metabolic process; cytosol;

Genes shared at least 2 KEGG pathways with SHMT1 (count: 10)

Gene Symbol	Pathway Count	Pathway List
SHMT2	4	Metabolic pathways; One carbon pool by folate; Glycine, serine and threonine metabolism; Cyanoamino acid metabolism;
AGXT2	2	Metabolic pathways; Glycine, serine and threonine metabolism;
ATIC	2	Metabolic pathways; One carbon pool by folate;
GGT1	2	Metabolic pathways; Cyanoamino acid metabolism;
GGT5	2	Metabolic pathways; Cyanoamino acid metabolism;
MAOA	2	Metabolic pathways; Glycine, serine and threonine metabolism;
MAOB	2	Metabolic pathways; Glycine, serine and threonine metabolism;
MTHFD2L	2	Metabolic pathways; One carbon pool by folate;
MTHFR	2	Metabolic pathways; One carbon pool by folate;
SARDH	2	Metabolic pathways; Glycine, serine and threonine metabolism;

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Region: chr17:18231187..18266856 View in gBrowse