ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SREBF1
Symbol Alias	SREBP1, bHLHd1, SREBP-1c
Approved Name	sterol regulatory element binding transcription factor 1
Location	17p11.2
Position	chr17:17714653-17740325, -
External Links	HGNC: 11289 Entrez Gene: 6720 Ensembl: ENSG00000072310 UCSC: uc002grt.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 44)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 44)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051591	response to cAMP	Biological Process		11
GO:0046983	protein dimerization activity	Molecular Function		26
GO:0070542	response to fatty acid	Biological Process		3
GO:0032526	response to retinoic acid	Biological Process		7
GO:0032570	response to progesterone stimulus	Biological Process		7
GO:0032810	sterol response element binding	Molecular Function	IDA[16407292]	1
GO:0032933	SREBP signaling pathway	Biological Process		1
GO:0030324	lung development	Biological Process		12
GO:0031065	positive regulation of histone deacetylation	Biological Process		4
GO:0032094	response to food	Biological Process		2
GO:0032403	protein complex binding	Molecular Function		27
GO:0044444	cytoplasmic part	Cellular Component		4
GO:0045542	positive regulation of cholesterol biosynthetic process	Biological Process		2
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12242332]	131
GO:0046676	negative regulation of insulin secretion	Biological Process		3
GO:0033762	response to glucagon stimulus	Biological Process		1
GO:0042493	response to drug	Biological Process		68
GO:0043234	protein complex	Cellular Component		45
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[8156598]	42
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005783	endoplasmic reticulum	Cellular Component	IDA[12202038]	100
GO:0008286	insulin receptor signaling pathway	Biological Process		32
GO:0008203	cholesterol metabolic process	Biological Process		16
GO:0007568	aging	Biological Process		29
GO:0006629	lipid metabolic process	Biological Process	TAS[8156598]	51
GO:0010867	positive regulation of triglyceride biosynthetic process	Biological Process		2
GO:0009749	response to glucose stimulus	Biological Process		10
GO:0009267	cellular response to starvation	Biological Process	ISS[16407292]	3
GO:0008610	lipid biosynthetic process	Biological Process		3
GO:0019901	protein kinase binding	Molecular Function		51
GO:0019217	regulation of fatty acid metabolic process	Biological Process		2
GO:0016021	integral to membrane	Cellular Component		845
GO:0012507	ER to Golgi transport vesicle membrane	Cellular Component		3
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0003677	DNA binding	Molecular Function		220
GO:0003682	chromatin binding	Molecular Function		48
GO:0000139	Golgi membrane	Cellular Component		95
GO:0003062	regulation of heart rate by chemical signal	Biological Process		1
GO:0005634	nucleus	Cellular Component	IDA[15358760]	770
GO:0005635	nuclear envelope	Cellular Component	TAS[8156598]	19
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[16407292]	132
GO:0005515	protein binding	Molecular Function		910

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04910	Insulin signaling pathway	29	Insulin binding to its receptor results in the tyrosine phos...... Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR. More...

Genes shared at least 5 GO terms with SREBF1 (count: 103)

Gene Symbol	Pathway Count	Pathway List
RELA	13	response to cAMP; response to progesterone stimulus; protein complex binding; positive regulation of transcription from RNA polymerase II promoter; response to drug; sequence-specific DNA binding; aging; protein kinase binding; DNA binding; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
ATF6	10	sequence-specific DNA binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; endoplasmic reticulum membrane; integral to membrane; Golgi membrane; nucleus; nuclear envelope; sequence-specific DNA binding transcription factor activity; protein binding;
POU2F3	8	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
TBX1	8	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
HES1	8	lung development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
NCOR1	8	positive regulation of histone deacetylation; sequence-specific DNA binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
GATA6	8	positive regulation of transcription from RNA polymerase II promoter; response to drug; protein kinase binding; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
HNF1B	8	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; response to glucose stimulus; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
KDM1A	8	positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
MEN1	8	positive regulation of transcription from RNA polymerase II promoter; protein complex; sequence-specific DNA binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding;
FOSL1	7	response to cAMP; response to progesterone stimulus; response to drug; regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
HEY2	7	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
TFAP2A	7	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding;
STRN3	7	protein complex binding; positive regulation of transcription from RNA polymerase II promoter; protein complex; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
PRKAA1	7	positive regulation of cholesterol biosynthetic process; transcription, DNA-dependent; insulin receptor signaling pathway; lipid biosynthetic process; chromatin binding; nucleus; protein binding;
ETS1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
HOXA5	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
IKZF1	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
MTA2	7	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
MYB	7	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; chromatin binding; sequence-specific DNA binding transcription factor activity; protein binding;
SLC6A3	6	response to cAMP; protein complex binding; response to drug; aging; integral to membrane; protein binding;
FOXF1	6	lung development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus;
LPIN1	6	positive regulation of histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; endoplasmic reticulum membrane; negative regulation of transcription from RNA polymerase II promoter; nucleus;
KAT5	6	protein complex binding; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
BARX2	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; chromatin binding; sequence-specific DNA binding transcription factor activity;
CBFA2T3	6	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; chromatin binding; Golgi membrane; sequence-specific DNA binding transcription factor activity; protein binding;
FOXC2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; insulin receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
FOXE1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
FOXG1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; aging; DNA binding; nucleus; protein binding;
HOXA1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
HOXA13	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA7	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
HOXB1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
MEIS2	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
NR5A1	6	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; chromatin binding; nucleus; protein binding;
RBPJ	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
NPC1	6	response to drug; endoplasmic reticulum; cholesterol metabolic process; integral to membrane; nuclear envelope; protein binding;
MAPK1	6	protein complex; transcription, DNA-dependent; insulin receptor signaling pathway; DNA binding; nucleus; protein binding;
CREBZF	6	sequence-specific DNA binding; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
DRAP1	6	sequence-specific DNA binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF24	6	sequence-specific DNA binding; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
HIRA	6	regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
HINFP	6	transcription, DNA-dependent; DNA binding; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
NCOR2	6	transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; chromatin binding; nucleus; protein binding;
TCF25	6	transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
CLOCK	5	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
EBF1	5	protein dimerization activity; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
ERBB2	5	protein dimerization activity; transcription, DNA-dependent; integral to membrane; nucleus; protein binding;
HES6	5	protein dimerization activity; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity;
ID2	5	protein dimerization activity; protein complex; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
NPAS2	5	protein dimerization activity; positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity;
BAD	5	response to progesterone stimulus; response to drug; response to glucose stimulus; protein kinase binding; protein binding;
NCF2	5	response to progesterone stimulus; response to drug; aging; response to glucose stimulus; protein binding;
FOXP1	5	lung development; positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; chromatin binding; nucleus;
VEGFA	5	lung development; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; protein binding;
NIPBL	5	positive regulation of histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding;
GHR	5	response to food; protein kinase binding; integral to membrane; nucleus; protein binding;
CCND1	5	protein complex binding; response to drug; protein kinase binding; nucleus; protein binding;
FLCN	5	protein complex binding; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
TMED10	5	protein complex binding; endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; protein binding;
ARID3C	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; chromatin binding; nucleus;
ATXN1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; nucleus; protein binding;
BSX	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
E2F5	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; sequence-specific DNA binding transcription factor activity; protein binding;
ESRRA	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; DNA binding; nucleus; protein binding;
GSK3B	5	positive regulation of transcription from RNA polymerase II promoter; response to drug; protein kinase binding; nucleus; protein binding;
IRF7	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; protein binding;
ISL1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; sequence-specific DNA binding transcription factor activity;
LHX2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
MAF	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
MED1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding;
NR4A2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; protein binding;
NRIP1	5	positive regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
ONECUT2	5	positive regulation of transcription from RNA polymerase II promoter; sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity;
SMARCB1	5	positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; protein binding;
SNW1	5	positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding;
SS18	5	positive regulation of transcription from RNA polymerase II promoter; response to drug; transcription, DNA-dependent; nucleus; protein binding;
UTF1	5	positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; nucleus; protein binding;
APOA1	5	response to drug; cholesterol metabolic process; lipid metabolic process; nucleus; protein binding;
SRCAP	5	protein complex; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; nucleus;
BATF2	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
GSC2	5	sequence-specific DNA binding; regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
HOXA9	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
LMX1B	5	sequence-specific DNA binding; transcription, DNA-dependent; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
PKNOX2	5	sequence-specific DNA binding; regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
PRDM1	5	sequence-specific DNA binding; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity;
PRKCB	5	regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; chromatin binding; nucleus; protein binding;
SP4	5	regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
TBX10	5	regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
ZNF367	5	regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
HMGA1	5	transcription, DNA-dependent; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity; protein binding;
RNF2	5	transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding;
ZNF189	5	transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;
FADS1	5	endoplasmic reticulum membrane; aging; cellular response to starvation; integral to membrane; nucleus;
LMAN1	5	endoplasmic reticulum membrane; integral to membrane; ER to Golgi transport vesicle membrane; Golgi membrane; protein binding;
LTC4S	5	endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nuclear envelope; protein binding;
MBTPS1	5	endoplasmic reticulum membrane; cholesterol metabolic process; lipid metabolic process; integral to membrane; Golgi membrane;
STX18	5	endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; Golgi membrane; protein binding;
SYVN1	5	endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; nucleus; protein binding;
TAPBP	5	endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane; Golgi membrane; protein binding;
APLP2	5	cholesterol metabolic process; integral to membrane; DNA binding; nucleus; protein binding;
ZNF202	5	lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; DNA binding; nucleus; sequence-specific DNA binding transcription factor activity;

Genes shared at least 2 KEGG pathways with SREBF1 (count: 0)

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Region: chr17:17714653..17740325 View in gBrowse