ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	STXBP3
Symbol Alias	UNC-18C
Approved Name	syntaxin binding protein 3
Location	1p13.3
Position	chr1:109289285-109352148, +
External Links	HGNC: 11446 Entrez Gene: 6814 Ensembl: ENSG00000116266 UCSC: uc001dvy.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_1	chr1:109103606-109682244 (NCBI36 / hg18)	578639	1p13.3	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005515	protein binding	Molecular Function	IPI[12773094]	910
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component		690
GO:0005829	cytosol	Cellular Component	IDA[18588921]	447
GO:0005886	plasma membrane	Cellular Component	IDA[18588921]	772
GO:0006904	vesicle docking involved in exocytosis	Biological Process		8
GO:0043312	neutrophil degranulation	Biological Process	IEP[18588921]	1
GO:0042581	specific granule	Cellular Component	IDA[18588921]	5
GO:0051291	protein heterooligomerization	Biological Process		10
GO:0045955	negative regulation of calcium ion-dependent exocytosis	Biological Process	IMP[12649283]	2
GO:0070820	tertiary granule	Cellular Component	IDA[18588921]	2
GO:0070527	platelet aggregation	Biological Process	IMP[12773094]	3
GO:0015031	protein transport	Biological Process		75
GO:0007596	blood coagulation	Biological Process		83
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0016323	basolateral plasma membrane	Cellular Component		29
GO:0019905	syntaxin binding	Molecular Function	IPI[15576373]	6
GO:0017075	syntaxin-1 binding	Molecular Function		8
GO:0031091	platelet alpha granule	Cellular Component	IDA[12773094]	2
GO:0030168	platelet activation	Biological Process		38

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with STXBP3 (count: 71)

Gene Symbol	Pathway Count	Pathway List
ARRB2	9	protein binding; nucleus; cytoplasm; cytosol; plasma membrane; protein transport; blood coagulation; basolateral plasma membrane; platelet activation;
ARRB1	8	protein binding; nucleus; cytoplasm; cytosol; plasma membrane; protein transport; blood coagulation; platelet activation;
ADRA2A	7	protein binding; cytoplasm; plasma membrane; negative regulation of calcium ion-dependent exocytosis; blood coagulation; basolateral plasma membrane; platelet activation;
MAPK1	7	protein binding; nucleus; nucleolus; cytoplasm; cytosol; blood coagulation; platelet activation;
PIK3CG	7	protein binding; cytoplasm; cytosol; plasma membrane; platelet aggregation; blood coagulation; platelet activation;
PRKCB	7	protein binding; nucleus; cytoplasm; cytosol; plasma membrane; blood coagulation; platelet activation;
STX4	7	protein binding; cytosol; plasma membrane; specific granule; blood coagulation; basolateral plasma membrane; platelet activation;
AIP	6	protein binding; nucleus; nucleolus; cytoplasm; cytosol; plasma membrane;
BAIAP2	6	protein binding; nucleus; nucleolus; cytoplasm; cytosol; plasma membrane;
BCAR1	6	protein binding; cytoplasm; cytosol; plasma membrane; blood coagulation; platelet activation;
GSK3B	6	protein binding; nucleus; nucleolus; cytoplasm; cytosol; plasma membrane;
HABP4	6	protein binding; nucleus; cytoplasm; cytosol; blood coagulation; platelet activation;
MALT1	6	protein binding; nucleus; nucleolus; cytoplasm; cytosol; plasma membrane;
MAPK3	6	protein binding; nucleus; nucleolus; cytosol; blood coagulation; platelet activation;
PDE2A	6	protein binding; nucleus; cytoplasm; cytosol; plasma membrane; blood coagulation;
RNF40	6	protein binding; nucleus; nucleolus; cytoplasm; plasma membrane; syntaxin-1 binding;
SNAP23	6	protein binding; nucleus; nucleolus; plasma membrane; specific granule; protein transport;
TJP1	6	protein binding; nucleus; cytoplasm; cytosol; plasma membrane; basolateral plasma membrane;
ADAM8	5	protein binding; cytoplasm; plasma membrane; specific granule; tertiary granule;
ADRA2C	5	protein binding; cytoplasm; plasma membrane; blood coagulation; platelet activation;
AKAP7	5	protein binding; nucleus; cytosol; plasma membrane; apical plasma membrane;
ALKBH8	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
APC	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
APOA1	5	protein binding; nucleus; plasma membrane; blood coagulation; platelet activation;
CACNA1A	5	protein binding; nucleus; cytoplasm; plasma membrane; syntaxin binding;
CBL	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
CDCA5	5	protein binding; nucleus; nucleolus; cytoplasm; plasma membrane;
CEP164	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
CEP57	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
CFL1	5	protein binding; nucleus; cytoplasm; blood coagulation; platelet activation;
CHD1L	5	protein binding; nucleus; nucleolus; cytoplasm; plasma membrane;
COG3	5	protein binding; nucleus; nucleolus; cytoplasm; plasma membrane;
COG5	5	protein binding; nucleus; nucleolus; cytosol; protein transport;
CRYAB	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
CTNND1	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
DAXX	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
DCPS	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
EHD3	5	protein binding; nucleus; cytoplasm; plasma membrane; blood coagulation;
ERBB2	5	protein binding; nucleus; plasma membrane; apical plasma membrane; basolateral plasma membrane;
F2RL2	5	protein binding; plasma membrane; blood coagulation; apical plasma membrane; platelet activation;
HSPA8	5	protein binding; nucleus; nucleolus; cytosol; plasma membrane;
IARS	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
ID2	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
ILK	5	protein binding; cytoplasm; cytosol; plasma membrane; protein heterooligomerization;
MAGI2	5	protein binding; nucleus; cytoplasm; plasma membrane; protein heterooligomerization;
MEN1	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
NCK1	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
NF2	5	protein binding; nucleus; nucleolus; cytoplasm; plasma membrane;
NUMA1	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
PAFAH1B1	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
PDCD4	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
PIK3R1	5	protein binding; cytosol; plasma membrane; blood coagulation; platelet activation;
PLCG2	5	protein binding; cytosol; plasma membrane; blood coagulation; platelet activation;
PPP1CA	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
PRC1	5	protein binding; nucleus; nucleolus; cytoplasm; plasma membrane;
PRKAA1	5	protein binding; nucleus; cytosol; protein heterooligomerization; apical plasma membrane;
PRKD1	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
PRKG1	5	protein binding; cytoplasm; cytosol; plasma membrane; blood coagulation;
RFWD2	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
RRP8	5	protein binding; nucleus; nucleolus; cytoplasm; plasma membrane;
SAP18	5	protein binding; nucleus; nucleolus; cytoplasm; plasma membrane;
SART1	5	protein binding; nucleus; nucleolus; cytoplasm; cytosol;
SNCA	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
SYK	5	protein binding; cytosol; plasma membrane; blood coagulation; platelet activation;
SYTL2	5	protein binding; nucleus; cytoplasm; plasma membrane; vesicle docking involved in exocytosis;
VPS33B	5	protein binding; cytoplasm; vesicle docking involved in exocytosis; protein transport; platelet alpha granule;
WWOX	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
WWP1	5	protein binding; nucleus; cytoplasm; cytosol; plasma membrane;
DGKH	5	nucleus; cytoplasm; plasma membrane; blood coagulation; platelet activation;
RILPL1	5	nucleus; nucleolus; cytoplasm; cytosol; plasma membrane;
SNAP29	5	nucleus; nucleolus; cytoplasm; plasma membrane; protein transport;

Genes shared at least 2 KEGG pathways with STXBP3 (count: 0)

View in gBrowse

Region: chr1:109289285..109352148 View in gBrowse