ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TIAM2
Symbol Alias	STEF
Approved Name	T-cell lymphoma invasion and metastasis 2
Location	6q25
Position	chr6:155153831-155581751, +
External Links	HGNC: 11806 Entrez Gene: 26230 Ensembl: ENSG00000146426 UCSC: uc003qqe.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.00003 locates intronic relative to this gene.	Trend

Gene related SNPs (count: 13)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs9384245	Chr6:155160128(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant	1(0/0/1)

LD-proxies (count: 12)

rs_ID	Location	Functional Annotation
rs12528403	Chr6:155210588(Fwd)	intron_variant; nc_transcript_variant
rs4870317	Chr6:155196194(Fwd)	intron_variant; nc_transcript_variant
rs7753068	Chr6:155219158(Fwd)	intron_variant; nc_transcript_variant
rs13202898	Chr6:155211015(Fwd)	intron_variant; nc_transcript_variant
rs7760792	Chr6:155218117(Fwd)	intron_variant; nc_transcript_variant
rs1980602	Chr6:155156221(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs13196046	Chr6:155221284(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs9375	Chr6:155155039(Fwd)	3_prime_UTR_variant; intron_variant; nc_transcript_variant
rs10485354	Chr6:155149943(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs911191	Chr6:155152311(Fwd)	intron_variant; upstream_gene_variant
rs12199781	Chr6:155162121(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs12201149	Chr6:155162163(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044255	cellular lipid metabolic process	Biological Process		30
GO:0035023	regulation of Rho protein signal transduction	Biological Process		9
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process		30
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	TAS[10512681]	17
GO:0005829	cytosol	Cellular Component		447
GO:0005057	receptor signaling protein activity	Molecular Function		9
GO:0005543	phospholipid binding	Molecular Function		61
GO:0005096	GTPase activator activity	Molecular Function		23
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function		11
GO:0006915	apoptotic process	Biological Process		111
GO:0030027	lamellipodium	Cellular Component		27
GO:0016020	membrane	Cellular Component		139
GO:0030426	growth cone	Cellular Component		20
GO:0030175	filopodium	Cellular Component		5

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04810	Regulation of actin cytoskeleton	48

Genes shared at least 5 GO terms with TIAM2 (count: 13)

Gene Symbol	Pathway Count	Pathway List
ARHGEF12	10	regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; cytosol; phospholipid binding; GTPase activator activity; small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process; membrane;
ARHGEF4	9	regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; guanyl-nucleotide exchange factor activity; cytosol; phospholipid binding; small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
TRIO	9	regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; guanyl-nucleotide exchange factor activity; cytosol; phospholipid binding; small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
FGD3	9	nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; guanyl-nucleotide exchange factor activity; cytosol; phospholipid binding; small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process; lamellipodium;
ARHGEF17	8	regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; guanyl-nucleotide exchange factor activity; cytosol; small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
ARHGEF2	8	regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; cytosol; phospholipid binding; small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
MCF2L	8	regulation of Rho protein signal transduction; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; cytosol; small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process; lamellipodium;
NET1	8	nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction; guanyl-nucleotide exchange factor activity; cytosol; phospholipid binding; small GTPase mediated signal transduction; Rho guanyl-nucleotide exchange factor activity; apoptotic process;
RGL1	5	cellular lipid metabolic process; small molecule metabolic process; regulation of small GTPase mediated signal transduction; cytosol; small GTPase mediated signal transduction;
SPATA13	5	regulation of Rho protein signal transduction; guanyl-nucleotide exchange factor activity; phospholipid binding; lamellipodium; filopodium;
ARHGAP20	5	regulation of small GTPase mediated signal transduction; cytosol; phospholipid binding; GTPase activator activity; small GTPase mediated signal transduction;
CHN2	5	regulation of small GTPase mediated signal transduction; cytosol; GTPase activator activity; small GTPase mediated signal transduction; membrane;
GAPVD1	5	regulation of small GTPase mediated signal transduction; guanyl-nucleotide exchange factor activity; cytosol; GTPase activator activity; membrane;

Genes shared at least 2 KEGG pathways with TIAM2 (count: 9)

Gene Symbol	Pathway Count	Pathway List
BCAR1	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;
CRKL	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;
MAPK1	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;
MAPK3	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;
PAK1	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;
PIK3CG	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;
PIK3R1	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;
ROCK2	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;
WASL	2	Chemokine signaling pathway; Regulation of actin cytoskeleton;

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Region: chr6:155153831..155581751 View in gBrowse