Gene Report
Basic Info
Approved Symbol |
TPCN2
|
Symbol Alias |
TPC2 |
Approved Name |
two pore segment channel 2 |
Location |
11q13.1 |
Position |
chr11:68816350-68858072, + |
External Links |
HGNC: 20820
Entrez Gene: 219931
Ensembl: ENSG00000162341
UCSC: uc001oos.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by CNV; Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 1)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 11)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04972 |
Pancreatic secretion |
30 |
The pancreas performs both exocrine and endocrine functions.......
The pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesize and secrete digestive enzymes. Stimulation of the cell by secretagogues such as acetylcholine (ACh) and cholecystokinin (CCK) causes the generation of an intracellular Ca2+ signal. This signal, in turn, triggers the fusion of the zymogen granules with the apical plasma membrane, leading to the polarised secretion of the enzymes. The major task of pancreatic duct cells is the secretion of fluid and bicarbonate ions (HCO3-), which neutralize the acidity of gastric contents that enter the duodenum. An increase in intracellular cAMP by secretin is one of the major signals of pancreatic HCO3- secretion. Activation of the CFTR Cl- channel and the CFTR-dependent Cl-/HCO3- exchange activities is responsible for cAMP-induced HCO3- secretion.
More...
|
Genes shared at least 5 GO terms with TPCN2 (count: 0)
Genes shared at least 2 KEGG pathways with TPCN2 (count: 0)
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