ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRIM5
Symbol Alias	RNF88, TRIM5alpha
Approved Name	tripartite motif containing 5
Previous Name	tripartite motif-containing 5
Name Alias	tripartite motif protein TRIM5, "tripartite motif protein TRIM"
Location	11p15
Position	chr11:5684425-5959849, -
External Links	HGNC: 16276 Entrez Gene: 85363 Ensembl: ENSG00000132256 UCSC: uc001mbm.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_29	chr11:5582423-7488751 (NCBI Build 36.1 (hg18))	1859865	11p15.4	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042802	identical protein binding	Molecular Function		70
GO:0031664	regulation of lipopolysaccharide-mediated signaling pathway	Biological Process		1
GO:0019048	virus-host interaction	Biological Process		54
GO:0008329	pattern recognition receptor activity	Molecular Function		2
GO:0045087	innate immune response	Biological Process		54
GO:0043410	positive regulation of MAPK cascade	Biological Process		17
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process		27
GO:0042803	protein homodimerization activity	Molecular Function	IPI[11331580]	113
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[15919943]	910
GO:0004842	ubiquitin-protein ligase activity	Molecular Function		52
GO:0002221	pattern recognition receptor signaling pathway	Biological Process		2
GO:0008270	zinc ion binding	Molecular Function		323
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005737	cytoplasm	Cellular Component		690
GO:0005730	nucleolus	Cellular Component		243
GO:0000932	cytoplasmic mRNA processing body	Cellular Component	IDA[12878161]	7
GO:0002218	activation of innate immune response	Biological Process		3
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:0051607	defense response to virus	Biological Process		15
GO:0070206	protein trimerization	Biological Process	IDA[17156811]	5
GO:0070534	protein K63-linked ubiquitination	Biological Process		3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TRIM5 (count: 65)

Gene Symbol	Pathway Count	Pathway List
RELA	9	identical protein binding; virus-host interaction; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein binding; cytoplasm; positive regulation of NF-kappaB transcription factor activity; defense response to virus;
PRKD1	8	identical protein binding; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein binding; Golgi apparatus; cytoplasm; positive regulation of NF-kappaB transcription factor activity;
MALT1	8	innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein binding; ubiquitin-protein ligase activity; cytoplasm; nucleolus; positive regulation of NF-kappaB transcription factor activity;
PYCARD	8	innate immune response; protein homodimerization activity; nucleus; protein binding; cytoplasm; activation of innate immune response; positive regulation of NF-kappaB transcription factor activity; defense response to virus;
PARK2	8	positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; Golgi apparatus; cytoplasm; protein K63-linked ubiquitination;
BNIP3	7	identical protein binding; virus-host interaction; protein homodimerization activity; nucleus; protein binding; cytoplasm; defense response to virus;
MAPK1	7	virus-host interaction; innate immune response; nucleus; protein binding; Golgi apparatus; cytoplasm; nucleolus;
TRIM22	7	virus-host interaction; nucleus; zinc ion binding; Golgi apparatus; cytoplasm; defense response to virus; protein trimerization;
TRIM32	7	innate immune response; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm; positive regulation of NF-kappaB transcription factor activity;
RCHY1	7	protein homodimerization activity; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm; nucleolus;
RNF40	7	protein homodimerization activity; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm; nucleolus;
FADD	6	identical protein binding; virus-host interaction; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding; defense response to virus;
SNCA	6	identical protein binding; nucleus; protein binding; zinc ion binding; Golgi apparatus; cytoplasm;
DAXX	6	virus-host interaction; protein homodimerization activity; nucleus; protein binding; cytoplasm; nucleolus;
MAPK3	6	virus-host interaction; innate immune response; nucleus; protein binding; Golgi apparatus; nucleolus;
MAVS	6	virus-host interaction; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding; activation of innate immune response; defense response to virus;
HERC5	6	innate immune response; nucleus; protein binding; ubiquitin-protein ligase activity; cytoplasm; defense response to virus;
TNFAIP3	6	innate immune response; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
BIRC3	6	positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
PRKCB	6	positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein binding; zinc ion binding; cytoplasm; positive regulation of NF-kappaB transcription factor activity;
RNF31	6	positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm; positive regulation of NF-kappaB transcription factor activity;
BARD1	6	protein homodimerization activity; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
CEP57	6	protein homodimerization activity; nucleus; protein binding; Golgi apparatus; cytoplasm; nucleolus;
TFAP2A	6	protein homodimerization activity; nucleus; protein binding; Golgi apparatus; cytoplasm; nucleolus;
KLHL20	6	nucleus; protein binding; ubiquitin-protein ligase activity; Golgi apparatus; cytoplasm; nucleolus;
ATXN1	5	identical protein binding; nucleus; protein binding; cytoplasm; nucleolus;
BAIAP2	5	identical protein binding; nucleus; protein binding; cytoplasm; nucleolus;
GPSM2	5	identical protein binding; nucleus; protein binding; cytoplasm; nucleolus;
IL12B	5	identical protein binding; protein homodimerization activity; protein binding; cytoplasm; defense response to virus;
MAP3K5	5	identical protein binding; virus-host interaction; innate immune response; protein homodimerization activity; protein binding;
MLL	5	identical protein binding; protein homodimerization activity; nucleus; protein binding; zinc ion binding;
PRC1	5	identical protein binding; nucleus; protein binding; cytoplasm; nucleolus;
PRPF19	5	identical protein binding; nucleus; protein binding; ubiquitin-protein ligase activity; cytoplasm;
SQSTM1	5	identical protein binding; protein homodimerization activity; protein binding; zinc ion binding; cytoplasmic mRNA processing body;
ZBTB16	5	identical protein binding; protein homodimerization activity; nucleus; protein binding; zinc ion binding;
NEDD4L	5	virus-host interaction; nucleus; protein binding; ubiquitin-protein ligase activity; cytoplasm;
PSMC3	5	virus-host interaction; nucleus; protein binding; cytoplasm; cytoplasmic mRNA processing body;
UBE3A	5	virus-host interaction; nucleus; protein binding; ubiquitin-protein ligase activity; cytoplasm;
CORO1A	5	innate immune response; protein homodimerization activity; nucleus; protein binding; cytoplasm;
TIRAP	5	innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein homodimerization activity; protein binding; positive regulation of NF-kappaB transcription factor activity;
TLR4	5	innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding; cytoplasm; positive regulation of NF-kappaB transcription factor activity;
BIRC2	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding;
TERF2IP	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; nucleus; protein binding; cytoplasm; positive regulation of NF-kappaB transcription factor activity;
TRAF1	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding; zinc ion binding; cytoplasm; positive regulation of NF-kappaB transcription factor activity;
TRIM13	5	positive regulation of I-kappaB kinase/NF-kappaB cascade; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
CRYAB	5	protein homodimerization activity; nucleus; protein binding; Golgi apparatus; cytoplasm;
FOXP1	5	protein homodimerization activity; nucleus; zinc ion binding; cytoplasm; nucleolus;
PAFAH1B1	5	protein homodimerization activity; nucleus; protein binding; cytoplasm; nucleolus;
PDE2A	5	protein homodimerization activity; nucleus; protein binding; Golgi apparatus; cytoplasm;
AATF	5	nucleus; protein binding; Golgi apparatus; cytoplasm; nucleolus;
ATXN2	5	nucleus; protein binding; Golgi apparatus; cytoplasm; nucleolus;
CBL	5	nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
COG3	5	nucleus; protein binding; Golgi apparatus; cytoplasm; nucleolus;
FUS	5	nucleus; protein binding; zinc ion binding; cytoplasm; nucleolus;
HERC2	5	nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; cytoplasm;
PGR	5	nucleus; protein binding; zinc ion binding; cytoplasm; nucleolus;
RBM4	5	nucleus; protein binding; zinc ion binding; cytoplasm; nucleolus;
RFWD2	5	nucleus; protein binding; zinc ion binding; cytoplasm; nucleolus;
RNF2	5	nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; nucleolus;
RNF20	5	nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; nucleolus;
RPS6KA4	5	nucleus; protein binding; cytoplasm; nucleolus; positive regulation of NF-kappaB transcription factor activity;
SART1	5	nucleus; protein binding; Golgi apparatus; cytoplasm; nucleolus;
ZFP91	5	nucleus; ubiquitin-protein ligase activity; zinc ion binding; nucleolus; protein K63-linked ubiquitination;
ZFR	5	nucleus; protein binding; zinc ion binding; cytoplasm; nucleolus;
G2E3	5	ubiquitin-protein ligase activity; zinc ion binding; Golgi apparatus; cytoplasm; nucleolus;

Genes shared at least 2 KEGG pathways with TRIM5 (count: 0)

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Region: chr11:5684425..5959849 View in gBrowse