ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TRPV5
Previous Symbol	ECAC1
Symbol Alias	CaT2
Approved Name	transient receptor potential cation channel, subfamily V, member 5
Previous Name	epithelial calcium channel 1
Location	7q34
Position	chr7:142605267-142630905, -
External Links	HGNC: 3145 Entrez Gene: 56302 Ensembl: ENSG00000127412 UCSC: uc003wby.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function		40

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051262	protein tetramerization	Biological Process		6
GO:0016324	apical plasma membrane	Cellular Component		51
GO:0005887	integral to plasma membrane	Cellular Component	IDA[15489237]	220
GO:0006816	calcium ion transport	Biological Process	TAS[15665527]	32
GO:0005516	calmodulin binding	Molecular Function		32

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04961	Endocrine and other factor-regulated calcium reabsorption	8	Calcium (Ca2+) is essential for numerous physiological funct...... Calcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. In kidney, the late part of the distal convoluted tubule (DCT) and the connecting tubule (CNT) are the site of active Ca2+ transport and precisely regulate Ca2+ reabsorption. Following Ca2+ entry through TRPV5, Ca2+ bound to calbindin-D28K diffuses to the basolateral side, where it is extruded into the blood compartment through NCX1 and to a lesser extent PMCA1b. In the urinary compartment, both klotho and tissue kallikrein (TK) increase the apical abundance of TRPV5. In the blood compartment, PTH, 1,25(OH)2D3 and estrogen increase the transcription and protein expression of the luminal Ca2+ channels, calbindins, and the extrusion systems. More...

Genes shared at least 5 GO terms with TRPV5 (count: 0)

Genes shared at least 2 KEGG pathways with TRPV5 (count: 0)

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Region: chr7:142605267..142630905 View in gBrowse