Gene Report
Basic Info
Approved Symbol |
TRPV5
|
Previous Symbol |
ECAC1 |
Symbol Alias |
CaT2 |
Approved Name |
transient receptor potential cation channel, subfamily V, member 5 |
Previous Name |
epithelial calcium channel 1 |
Location |
7q34 |
Position |
chr7:142605267-142630905, - |
External Links |
HGNC: 3145
Entrez Gene: 56302
Ensembl: ENSG00000127412
UCSC: uc003wby.1
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by PBA pathway |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 6)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04961 |
Endocrine and other factor-regulated calcium reabsorption |
8 |
Calcium (Ca2+) is essential for numerous physiological funct......
Calcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. In kidney, the late part of the distal convoluted tubule (DCT) and the connecting tubule (CNT) are the site of active Ca2+ transport and precisely regulate Ca2+ reabsorption. Following Ca2+ entry through TRPV5, Ca2+ bound to calbindin-D28K diffuses to the basolateral side, where it is extruded into the blood compartment through NCX1 and to a lesser extent PMCA1b. In the urinary compartment, both klotho and tissue kallikrein (TK) increase the apical abundance of TRPV5. In the blood compartment, PTH, 1,25(OH)2D3 and estrogen increase the transcription and protein expression of the luminal Ca2+ channels, calbindins, and the extrusion systems.
More...
|
Genes shared at least 5 GO terms with TRPV5 (count: 0)
Genes shared at least 2 KEGG pathways with TRPV5 (count: 0)
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