ADHDgene Database

Gene Report

Basic Info

Approved Symbol	UBOX5
Symbol Alias	UIP5, KIAA0860, Ubce7ip5, RNF37
Approved Name	U-box domain containing 5
Location	20p13
Position	chr20:3088219-3140842, -
External Links	HGNC: 17777 Entrez Gene: 22888 Ensembl: ENSG00000185019 UCSC: uc002whw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_35	chr20:3036010-3839896 (NCBI Build 36.1 (hg18))	803887	20p13	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 5)

ID	Name	Type	No. of Genes in ADHDgene
GO:0034450	ubiquitin-ubiquitin ligase activity	Molecular Function	3
GO:0000151	ubiquitin ligase complex	Cellular Component	15
GO:0000209	protein polyubiquitination	Biological Process	23
GO:0005634	nucleus	Cellular Component	770
GO:0008270	zinc ion binding	Molecular Function	323

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with UBOX5 (count: 0)

Genes shared at least 2 KEGG pathways with UBOX5 (count: 0)

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Region: chr20:3088219..3140842 View in gBrowse