ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	UGT1A3
Symbol Alias	UGT1C
Approved Name	UDP glucuronosyltransferase 1 family, polypeptide A3
Previous Name	UDP glycosyltransferase 1 family, polypeptide A3
Location	2q37
Position	chr2:234637754-234681945, +
External Links	HGNC: 12535 Entrez Gene: 54659 Ensembl: ENSG00000243135
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 15)

Literature-origin SNPs (count: 0)

LD-proxies (count: 15)

rs_ID	Location	Functional Annotation
rs4663964	Chr2:234650236(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs3796088	Chr2:234651800(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs28899189	Chr2:234634324(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs28898621	Chr2:234639211(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs17863798	Chr2:234656735(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs17862878	Chr2:234661948(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs4663968	Chr2:234655144(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs12466997	Chr2:234656517(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs3771342	Chr2:234672663(Fwd)	NMD_transcript_variant; intron_variant
rs17864705	Chr2:234672328(Fwd)	NMD_transcript_variant; intron_variant
rs2003569	Chr2:234667937(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs12052787	Chr2:234666581(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant
rs1018124	Chr2:234676118(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant
rs12479045	Chr2:234673588(Fwd)	NMD_transcript_variant; intron_variant
rs17868342	Chr2:234673516(Fwd)	NMD_transcript_variant; intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 12)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008152	metabolic process	Biological Process	TAS[9295054]	10
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0001972	retinoic acid binding	Molecular Function		12
GO:0052697	xenobiotic glucuronidation	Biological Process		5
GO:0052696	flavonoid glucuronidation	Biological Process		5
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0042573	retinoic acid metabolic process	Biological Process		7
GO:0019899	enzyme binding	Molecular Function		47
GO:0016021	integral to membrane	Cellular Component		845
GO:0015020	glucuronosyltransferase activity	Molecular Function		21
GO:0008194	UDP-glycosyltransferase activity	Molecular Function	TAS[9295054]	1

Gene related KEGG pathways (count: 11)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00860	Porphyrin and chlorophyll metabolism	24
hsa00983	Drug metabolism - other enzymes	25
hsa00514	Other types of O-glycan biosynthesis	22	O-mannosyl glycans are a type of O-glycans that are found bo...... O-mannosyl glycans are a type of O-glycans that are found both in eukaryotes and prokaryotes. Biosynthesis of O-mannosyl glycans is initiated by the transfer of mannose from Man-P-Dol to serine or threonine residue, which is catalyzed by protein O-mannosyltransferases POMT1 and POMT2. Defects of these genes are linked to human diseases, such as muscular dystrophies caused by reduced O-mannosylation of alpha-dystroglycan in skeletal muscles [DS:H00120]. More...
hsa00053	Ascorbate and aldarate metabolism	20
hsa00040	Pentose and glucuronate interconversions	21
hsa00500	Starch and sucrose metabolism	26
hsa00982	Drug metabolism - cytochrome P450	29
hsa00140	Steroid hormone biosynthesis	24	Steroid hormones derived from cholesterol are a class of bio...... Steroid hormones derived from cholesterol are a class of biologically active compounds in vertebrates. The cholesterol side-chain cleavage enzyme CYP11A1 catalyzes conversion of cholesterol, a C27 compound, to the first C21 steroid, pregnenolone, which is converted by a bifunctional enzyme complex to the gestagen hormone, progesterone [MD:M00107]. Pregnenolone and progesterone are the starting materials for the three groups of steroids: C21 steroids of glucocorticoids and mineralocorticoids, C19 steroids of androgens, and C18 steroids of estrogens. (i) Progesterone is converted by hydroxylations at carbons 21 and 11 to corticosterone, which is further modified by hydroxylation and oxydoreduction at carbon 18 to yield aldosterone, a mineralcorticoid [MD:M00108]. Cortisol, the main glucocorticoid, is formed from 17alpha-hydroxyprogesterone with 11-deoxycortisol as an intermediate [MD:M00109]. (ii) Male hormone testosterone is formed from pregnenolone by two pathways, delta5 pathway via dehydroepiandrosterone and delta4 pathway via androstenedione [MD:M00110]. The enzyme CYP17A1 is responsible for the 17,20 lyase and 17alpha-hydroxylase activities in respective pathways. (iii) Female hormones estrone and estradiol are formed from testosterone and 4-androstene-3,17-dione by oxidative removal of the C19 methyl group and subsequent aromatization of ring A [MD:M00111]. In addition to these three groups, recent studies show that there is another group, termed neurosteroids, synthesized in the brain rather than the peripheral endocrine gland. More...
hsa00830	Retinol metabolism	20
hsa00980	Metabolism of xenobiotics by cytochrome P450	26

Genes shared at least 5 GO terms with UGT1A3 (count: 8)

Gene Symbol	Pathway Count	Pathway List
UGT1A9	11	metabolic process; endoplasmic reticulum membrane; retinoic acid binding; xenobiotic glucuronidation; flavonoid glucuronidation; protein heterodimerization activity; protein homodimerization activity; retinoic acid metabolic process; enzyme binding; integral to membrane; glucuronosyltransferase activity;
UGT1A7	10	endoplasmic reticulum membrane; retinoic acid binding; xenobiotic glucuronidation; flavonoid glucuronidation; protein heterodimerization activity; protein homodimerization activity; retinoic acid metabolic process; enzyme binding; integral to membrane; glucuronosyltransferase activity;
UGT1A8	10	endoplasmic reticulum membrane; retinoic acid binding; xenobiotic glucuronidation; flavonoid glucuronidation; protein heterodimerization activity; protein homodimerization activity; retinoic acid metabolic process; enzyme binding; integral to membrane; glucuronosyltransferase activity;
UGT1A1	9	endoplasmic reticulum membrane; retinoic acid binding; xenobiotic glucuronidation; flavonoid glucuronidation; protein heterodimerization activity; protein homodimerization activity; retinoic acid metabolic process; enzyme binding; glucuronosyltransferase activity;
UGT1A10	8	metabolic process; endoplasmic reticulum membrane; retinoic acid binding; protein heterodimerization activity; protein homodimerization activity; enzyme binding; integral to membrane; glucuronosyltransferase activity;
UGT1A6	8	metabolic process; endoplasmic reticulum membrane; retinoic acid binding; protein heterodimerization activity; protein homodimerization activity; enzyme binding; integral to membrane; glucuronosyltransferase activity;
UGT1A4	7	endoplasmic reticulum membrane; retinoic acid binding; protein heterodimerization activity; protein homodimerization activity; enzyme binding; integral to membrane; glucuronosyltransferase activity;
UGT2B4	5	metabolic process; endoplasmic reticulum membrane; retinoic acid binding; integral to membrane; glucuronosyltransferase activity;

Genes shared at least 2 KEGG pathways with UGT1A3 (count: 47)

Gene Symbol	Pathway Count	Pathway List
UGT1A1	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT1A10	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT1A4	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT1A5	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT1A6	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT1A7	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT1A8	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT1A9	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2A1	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2A2	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2A3	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2B10	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2B11	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2B15	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2B17	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2B28	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2B4	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
UGT2B7	11	Metabolic pathways; Porphyrin and chlorophyll metabolism; Drug metabolism - other enzymes; Other types of O-glycan biosynthesis; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions; Starch and sucrose metabolism; Drug metabolism - cytochrome P450; Steroid hormone biosynthesis; Retinol metabolism; Metabolism of xenobiotics by cytochrome P450;
ALDH3A1	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3A2	3	Metabolic pathways; Ascorbate and aldarate metabolism; Pentose and glucuronate interconversions;
ALDH3B1	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALDH3B2	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
CYP2E1	3	Metabolic pathways; Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
ALAD	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
BCMO1	2	Metabolic pathways; Retinol metabolism;
CES1	2	Metabolic pathways; Drug metabolism - other enzymes;
CES5A	2	Metabolic pathways; Drug metabolism - other enzymes;
COMT	2	Metabolic pathways; Steroid hormone biosynthesis;
CRYL1	2	Metabolic pathways; Pentose and glucuronate interconversions;
EARS2	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
ENPP1	2	Metabolic pathways; Starch and sucrose metabolism;
ENPP3	2	Metabolic pathways; Starch and sucrose metabolism;
FECH	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
FUT4	2	Metabolic pathways; Other types of O-glycan biosynthesis;
HK1	2	Metabolic pathways; Starch and sucrose metabolism;
HKDC1	2	Metabolic pathways; Starch and sucrose metabolism;
HMBS	2	Metabolic pathways; Porphyrin and chlorophyll metabolism;
HSD17B2	2	Metabolic pathways; Steroid hormone biosynthesis;
HSD17B3	2	Metabolic pathways; Steroid hormone biosynthesis;
ITPA	2	Metabolic pathways; Drug metabolism - other enzymes;
MAOA	2	Metabolic pathways; Drug metabolism - cytochrome P450;
MAOB	2	Metabolic pathways; Drug metabolism - cytochrome P450;
NAT2	2	Metabolic pathways; Drug metabolism - other enzymes;
UPB1	2	Metabolic pathways; Drug metabolism - other enzymes;
GSTP1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT1	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;
GSTT2	2	Drug metabolism - cytochrome P450; Metabolism of xenobiotics by cytochrome P450;

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Region: chr2:234637754..234681945 View in gBrowse