ADHDgene Database

Gene Report

Basic Info

Approved Symbol	VPS37C
Symbol Alias	FLJ20847
Approved Name	vacuolar protein sorting 37 homolog C (S. cerevisiae)
Previous Name	vacuolar protein sorting 37C (yeast)
Location	11q12.2
Position	chr11:60897728-60928916, -
External Links	HGNC: 26097 Entrez Gene: 55048 Ensembl: ENSG00000167987 UCSC: uc001nqv.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 9)

ID	Name	Type	No. of Genes in ADHDgene
GO:0031902	late endosome membrane	Cellular Component	15
GO:0043231	intracellular membrane-bounded organelle	Cellular Component	62
GO:0016044	cellular membrane organization	Biological Process	24
GO:0016197	endosomal transport	Biological Process	11
GO:0015031	protein transport	Biological Process	75
GO:0016032	viral reproduction	Biological Process	57
GO:0005634	nucleus	Cellular Component	770
GO:0010008	endosome membrane	Cellular Component	27
GO:0046788	egress of virus within host cell	Biological Process	4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04144	Endocytosis	39	Endocytosis is a mechanism for cells to remove ligands, nutr...... Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type. More...

Genes shared at least 5 GO terms with VPS37C (count: 3)

Gene Symbol	Pathway Count	Pathway List
VPS37D	7	late endosome membrane; cellular membrane organization; endosomal transport; protein transport; viral reproduction; endosome membrane; egress of virus within host cell;
UBB	5	cellular membrane organization; endosomal transport; viral reproduction; endosome membrane; egress of virus within host cell;
UBC	5	cellular membrane organization; endosomal transport; viral reproduction; endosome membrane; egress of virus within host cell;

Genes shared at least 2 KEGG pathways with VPS37C (count: 0)

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Region: chr11:60897728..60928916 View in gBrowse