ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	XPO1
Symbol Alias	CRM1, emb
Approved Name	exportin 1 (CRM1 homolog, yeast)
Previous Name	exportin 1 (CRM1, yeast, homolog)
Location	2p15
Position	chr2:61704984-61765761, -
External Links	HGNC: 12825 Entrez Gene: 7514 Ensembl: ENSG00000082898 UCSC: uc002sbj.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.0000289 locates 3'-UTR relative to this gene.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1050567	Chr2:61705663(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0019904	protein domain specific binding	Molecular Function		40
GO:0019058	viral infectious cycle	Biological Process		15
GO:0019048	virus-host interaction	Biological Process		54
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0042176	regulation of protein catabolic process	Biological Process		3
GO:0034504	protein localization to nucleus	Biological Process		3
GO:0030529	ribonucleoprotein complex	Cellular Component	IDA[18809582]	23
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process		13
GO:0051028	mRNA transport	Biological Process		8
GO:0046825	regulation of protein export from nucleus	Biological Process		2
GO:0042493	response to drug	Biological Process		68
GO:0005515	protein binding	Molecular Function	IPI[16319068]	910
GO:0005635	nuclear envelope	Cellular Component	TAS[9368044]	19
GO:0005642	annulate lamellae	Cellular Component	IDA[12210765]	1
GO:0005643	nuclear pore	Cellular Component		9
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005730	nucleolus	Cellular Component		243
GO:0005737	cytoplasm	Cellular Component	TAS[9368044]	690
GO:0005829	cytosol	Cellular Component		447
GO:0006611	protein export from nucleus	Biological Process		4
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process		14
GO:0008565	protein transporter activity	Molecular Function		11
GO:0010467	gene expression	Biological Process		140
GO:0010824	regulation of centrosome duplication	Biological Process		3
GO:0015030	Cajal body	Cellular Component		11
GO:0016032	viral reproduction	Biological Process		57
GO:0016070	RNA metabolic process	Biological Process		46
GO:0000087	M phase of mitotic cell cycle	Biological Process		19
GO:0000236	mitotic prometaphase	Biological Process		17
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0000776	kinetochore	Cellular Component	IDA[17363900]	15
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005215	transporter activity	Molecular Function		41
GO:0003723	RNA binding	Molecular Function		104

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03008	Ribosome biogenesis in eukaryotes	12	Ribosomes are the cellular factories responsible for making ...... Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. More...
hsa03013	RNA transport	15	RNA transport from the nucleus to the cytoplasm is fundamen...... RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. More...

Genes shared at least 5 GO terms with XPO1 (count: 118)

Gene Symbol	Pathway Count	Pathway List
UBB	11	mRNA metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; protein binding; nucleoplasm; cytosol; transforming growth factor beta receptor signaling pathway; gene expression; viral reproduction; RNA metabolic process; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle;
UBC	11	mRNA metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; protein binding; nucleoplasm; cytosol; transforming growth factor beta receptor signaling pathway; gene expression; viral reproduction; RNA metabolic process; negative regulation of transcription from RNA polymerase II promoter; mitotic cell cycle;
RAN	10	viral infectious cycle; virus-host interaction; protein binding; nuclear pore; nucleoplasm; cytoplasm; cytosol; protein export from nucleus; gene expression; viral reproduction;
RPS9	10	viral infectious cycle; mRNA metabolic process; ribonucleoprotein complex; protein binding; nucleolus; cytoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process;
NEDD4L	10	virus-host interaction; regulation of protein catabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; protein binding; nucleoplasm; cytoplasm; cytosol; transforming growth factor beta receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter;
PSMC3	10	virus-host interaction; mRNA metabolic process; protein binding; nucleoplasm; cytoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; mitotic cell cycle;
RPL14	9	viral infectious cycle; mRNA metabolic process; protein binding; cytoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
RPS25	9	viral infectious cycle; mRNA metabolic process; nucleolus; cytoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
RPS3	9	viral infectious cycle; mRNA metabolic process; ribonucleoprotein complex; protein binding; cytoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process;
PSMB7	9	virus-host interaction; mRNA metabolic process; protein binding; nucleoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; mitotic cell cycle;
NCBP1	9	mRNA metabolic process; ribonucleoprotein complex; protein binding; nucleoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
PAFAH1B1	9	protein binding; nuclear envelope; nucleolus; cytoplasm; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
SMC1A	9	protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
RPL13	8	viral infectious cycle; mRNA metabolic process; protein binding; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
RPL35	8	viral infectious cycle; mRNA metabolic process; nucleolus; cytoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process;
RPS15A	8	viral infectious cycle; mRNA metabolic process; cytoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
HNRNPA1	8	virus-host interaction; ribonucleoprotein complex; mRNA transport; nucleoplasm; nucleolus; cytoplasm; gene expression; RNA binding;
HSPA8	8	virus-host interaction; mRNA metabolic process; ribonucleoprotein complex; protein binding; nucleolus; cytosol; gene expression; RNA metabolic process;
PSMD5	8	mRNA metabolic process; protein binding; nucleoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; mitotic cell cycle;
PSMD7	8	mRNA metabolic process; protein binding; nucleoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; mitotic cell cycle;
PSME1	8	mRNA metabolic process; nucleoplasm; cytoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; mitotic cell cycle;
MEN1	8	protein binding; nucleoplasm; nucleolus; cytoplasm; cytosol; transforming growth factor beta receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter;
PLK1	8	protein binding; nucleoplasm; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; negative regulation of transcription from RNA polymerase II promoter; kinetochore; mitotic cell cycle;
NDE1	7	protein domain specific binding; protein binding; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
FAU	7	viral infectious cycle; mRNA metabolic process; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
RPL12	7	viral infectious cycle; mRNA metabolic process; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
RPL37	7	viral infectious cycle; mRNA metabolic process; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
RPL38	7	viral infectious cycle; mRNA metabolic process; cytosol; gene expression; viral reproduction; RNA metabolic process; RNA binding;
DCPS	7	mRNA metabolic process; protein binding; nucleolus; cytoplasm; cytosol; gene expression; RNA metabolic process;
PSME2	7	mRNA metabolic process; nucleoplasm; cytosol; gene expression; viral reproduction; RNA metabolic process; mitotic cell cycle;
GSK3B	7	ribonucleoprotein complex; response to drug; protein binding; nucleolus; cytoplasm; cytosol; protein export from nucleus;
HNRNPA2B1	7	ribonucleoprotein complex; protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression; RNA binding;
NUP62	7	ribonucleoprotein complex; mRNA transport; protein binding; nuclear envelope; nuclear pore; cytoplasm; viral reproduction;
RPL37A	6	viral infectious cycle; mRNA metabolic process; cytosol; gene expression; viral reproduction; RNA metabolic process;
RPS12	6	viral infectious cycle; mRNA metabolic process; cytosol; gene expression; viral reproduction; RNA metabolic process;
MAPK1	6	virus-host interaction; protein binding; nucleoplasm; nucleolus; cytoplasm; cytosol;
MAPK3	6	virus-host interaction; protein binding; nucleoplasm; nucleolus; cytosol; gene expression;
NXF1	6	virus-host interaction; protein binding; nuclear pore; nucleoplasm; cytosol; gene expression;
RELA	6	virus-host interaction; response to drug; protein binding; nucleoplasm; cytoplasm; cytosol;
SNW1	6	virus-host interaction; protein binding; nucleoplasm; nucleolus; gene expression; negative regulation of transcription from RNA polymerase II promoter;
TCEB1	6	virus-host interaction; protein binding; nucleoplasm; cytosol; gene expression; viral reproduction;
CNOT6	6	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process; RNA binding;
DDX6	6	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process; RNA binding;
LSM4	6	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process; RNA binding;
PATL1	6	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process; RNA binding;
PSMA8	6	mRNA metabolic process; cytosol; gene expression; viral reproduction; RNA metabolic process; mitotic cell cycle;
SMG1	6	mRNA metabolic process; protein binding; cytoplasm; cytosol; gene expression; RNA metabolic process;
SMG7	6	mRNA metabolic process; protein binding; cytoplasm; cytosol; gene expression; RNA metabolic process;
ATXN2	6	ribonucleoprotein complex; protein binding; nucleolus; cytoplasm; RNA metabolic process; RNA binding;
DHX9	6	ribonucleoprotein complex; protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression;
MVP	6	ribonucleoprotein complex; mRNA transport; response to drug; protein binding; nuclear pore; cytoplasm;
PPP1CA	6	negative regulation of transforming growth factor beta receptor signaling pathway; protein binding; nucleolus; cytoplasm; cytosol; transforming growth factor beta receptor signaling pathway;
CLASP1	6	protein binding; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
CLASP2	6	protein binding; cytoplasm; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
E2F5	6	protein binding; nucleoplasm; cytoplasm; transforming growth factor beta receptor signaling pathway; gene expression; mitotic cell cycle;
EFTUD2	6	protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression; Cajal body;
FUS	6	protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression; RNA binding;
HNRNPH1	6	protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression; RNA binding;
INCENP	6	protein binding; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
KIF2C	6	protein binding; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
MAPRE1	6	protein binding; cytoplasm; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
NCOR1	6	protein binding; nucleoplasm; cytoplasm; transforming growth factor beta receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter;
NCOR2	6	protein binding; nucleoplasm; nucleolus; transforming growth factor beta receptor signaling pathway; gene expression; negative regulation of transcription from RNA polymerase II promoter;
NUMA1	6	protein binding; nucleoplasm; nucleolus; cytoplasm; cytosol; mitotic cell cycle;
PDCD4	6	protein binding; nucleolus; cytoplasm; cytosol; RNA metabolic process; RNA binding;
RBPJ	6	protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression; negative regulation of transcription from RNA polymerase II promoter;
SART1	6	protein binding; nucleoplasm; nucleolus; cytoplasm; cytosol; Cajal body;
SMC3	6	protein binding; nucleoplasm; cytoplasm; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
SNRPD1	6	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process; RNA binding;
SNRPG	6	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process; RNA binding;
SSRP1	6	protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression; viral reproduction;
U2AF1	6	protein binding; nucleoplasm; nucleolus; gene expression; Cajal body; RNA binding;
ZW10	6	protein binding; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
CENPC1	6	cytoplasm; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; kinetochore; mitotic cell cycle;
ARRB2	5	protein domain specific binding; protein binding; cytoplasm; cytosol; transforming growth factor beta receptor signaling pathway;
SNCA	5	protein domain specific binding; response to drug; protein binding; cytoplasm; cytosol;
TJP1	5	protein domain specific binding; response to drug; protein binding; cytoplasm; cytosol;
BANF1	5	virus-host interaction; protein binding; nucleoplasm; cytosol; viral reproduction;
BNIP3	5	virus-host interaction; protein binding; nuclear envelope; nucleoplasm; cytoplasm;
DAXX	5	virus-host interaction; protein binding; nucleolus; cytoplasm; cytosol;
HMGA1	5	virus-host interaction; protein binding; nucleoplasm; cytosol; viral reproduction;
KAT5	5	virus-host interaction; protein binding; nucleolus; cytosol; negative regulation of transcription from RNA polymerase II promoter;
RQCD1	5	mRNA metabolic process; protein binding; cytosol; gene expression; RNA metabolic process;
TNKS1BP1	5	mRNA metabolic process; cytoplasm; cytosol; gene expression; RNA metabolic process;
CPSF3	5	ribonucleoprotein complex; protein binding; nucleoplasm; gene expression; RNA binding;
NUPL2	5	mRNA transport; nuclear pore; cytosol; protein export from nucleus; viral reproduction;
CCND1	5	response to drug; protein binding; nucleoplasm; cytosol; mitotic cell cycle;
NCF2	5	response to drug; protein binding; nucleolus; cytoplasm; cytosol;
SRP19	5	response to drug; nucleolus; cytoplasm; cytosol; gene expression;
ALKBH8	5	protein binding; nucleolus; cytoplasm; cytosol; RNA binding;
CEP164	5	protein binding; nucleolus; cytoplasm; cytosol; mitotic cell cycle;
CEP57	5	protein binding; nucleolus; cytoplasm; cytosol; mitotic cell cycle;
CKAP5	5	protein binding; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
DGCR8	5	protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression;
IARS	5	protein binding; nucleolus; cytoplasm; cytosol; gene expression;
ID2	5	protein binding; nucleolus; cytoplasm; cytosol; negative regulation of transcription from RNA polymerase II promoter;
IRF7	5	protein binding; nucleoplasm; cytoplasm; cytosol; negative regulation of transcription from RNA polymerase II promoter;
KIF23	5	protein binding; nucleoplasm; cytosol; M phase of mitotic cell cycle; mitotic cell cycle;
MED1	5	protein binding; nucleoplasm; nucleolus; gene expression; negative regulation of transcription from RNA polymerase II promoter;
MPHOSPH6	5	protein binding; nucleolus; cytoplasm; M phase of mitotic cell cycle; RNA binding;
PGR	5	protein binding; nucleoplasm; nucleolus; cytoplasm; gene expression;
PRPF4	5	protein binding; nucleoplasm; nucleolus; gene expression; Cajal body;
RBM4	5	protein binding; nucleoplasm; nucleolus; cytoplasm; RNA binding;
RCC1	5	protein binding; nucleoplasm; nucleolus; cytoplasm; viral reproduction;
RFWD2	5	protein binding; nucleoplasm; nucleolus; cytoplasm; cytosol;
RRM2	5	protein binding; nucleoplasm; cytoplasm; cytosol; mitotic cell cycle;
SF3A1	5	protein binding; nucleoplasm; nucleolus; gene expression; RNA binding;
SNRPB	5	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
SNRPD2	5	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
SNRPD3	5	protein binding; nucleoplasm; cytosol; gene expression; RNA metabolic process;
TAF10	5	protein binding; nucleoplasm; cytoplasm; gene expression; viral reproduction;
TAF13	5	protein binding; nucleoplasm; nucleolus; gene expression; viral reproduction;
XRCC5	5	protein binding; nucleoplasm; nucleolus; cytoplasm; viral reproduction;
YAP1	5	protein binding; nucleoplasm; cytoplasm; cytosol; gene expression;
CENPN	5	nucleoplasm; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
CENPP	5	nucleoplasm; cytosol; M phase of mitotic cell cycle; mitotic prometaphase; mitotic cell cycle;
SNRPF	5	nucleoplasm; cytosol; gene expression; RNA metabolic process; RNA binding;
TAF4B	5	nucleoplasm; nucleolus; cytoplasm; gene expression; viral reproduction;

Genes shared at least 2 KEGG pathways with XPO1 (count: 5)

Gene Symbol	Pathway Count	Pathway List
C9orf23	2	Ribosome biogenesis in eukaryotes; RNA transport;
NMD3	2	Ribosome biogenesis in eukaryotes; RNA transport;
NXF1	2	Ribosome biogenesis in eukaryotes; RNA transport;
RAN	2	Ribosome biogenesis in eukaryotes; RNA transport;
RPP30	2	Ribosome biogenesis in eukaryotes; RNA transport;

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Region: chr2:61704984..61765761 View in gBrowse