ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	YAP1
Symbol Alias	YAP65
Approved Name	Yes-associated protein 1
Previous Name	Yes-associated protein 1, 65kDa
Location	11q13
Position	chr11:101981192-102104154, +
External Links	HGNC: 16262 Entrez Gene: 10413 Ensembl: ENSG00000137693 UCSC: uc001pgt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)
11q22	chr11:97200000-110400000	1 (1/0/0)

Gene related GO terms (count: 34)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 34)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005634	nucleus	Cellular Component	IDA[18280240]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005667	transcription factor complex	Cellular Component		51
GO:0005737	cytoplasm	Cellular Component	IDA[18158288]	690
GO:0003682	chromatin binding	Molecular Function		48
GO:0003713	transcription coactivator activity	Molecular Function	IDA[18280240]	52
GO:0003714	transcription corepressor activity	Molecular Function	IDA[18158288]	29
GO:0005515	protein binding	Molecular Function	IPI[9305852]	910
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity	Molecular Function		1
GO:0001570	vasculogenesis	Biological Process		10
GO:0003143	embryonic heart tube morphogenesis	Biological Process		3
GO:0044212	transcription regulatory region DNA binding	Molecular Function	IDA[18280240]	23
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0046622	positive regulation of organ growth	Biological Process		1
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0030903	notochord development	Biological Process		1
GO:0030857	negative regulation of epithelial cell differentiation	Biological Process		2
GO:0035329	hippo signaling cascade	Biological Process		5
GO:0035019	somatic stem cell maintenance	Biological Process		7
GO:0010467	gene expression	Biological Process		140
GO:0008284	positive regulation of cell proliferation	Biological Process		69
GO:0030216	keratinocyte differentiation	Biological Process		9
GO:0010837	regulation of keratinocyte proliferation	Biological Process		2
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0005829	cytosol	Cellular Component		447
GO:0008283	cell proliferation	Biological Process	IDA[17974916]	60
GO:0006974	response to DNA damage stimulus	Biological Process	IDA[18280240]	37
GO:0060242	contact inhibition	Biological Process	IDA[17974916]	2
GO:0070064	proline-rich region binding	Molecular Function		4
GO:0048339	paraxial mesoderm development	Biological Process		1
GO:0048368	lateral mesoderm development	Biological Process		1
GO:0090263	positive regulation of canonical Wnt receptor signaling pathway	Biological Process		9
GO:0071480	cellular response to gamma radiation	Biological Process	IDA[18280240]	4
GO:0072091	regulation of stem cell proliferation	Biological Process		1

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with YAP1 (count: 137)

Gene Symbol	Pathway Count	Pathway List
MEN1	11	nucleus; nucleoplasm; cytoplasm; chromatin binding; protein binding; transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter; cytosol; response to DNA damage stimulus;
RELA	11	nucleus; nucleoplasm; transcription factor complex; cytoplasm; chromatin binding; protein binding; transcription regulatory region DNA binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; cytosol;
MED1	10	nucleus; nucleoplasm; chromatin binding; transcription coactivator activity; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; gene expression; keratinocyte differentiation; transcription initiation from RNA polymerase II promoter;
NCOR1	10	nucleus; nucleoplasm; transcription factor complex; cytoplasm; chromatin binding; transcription corepressor activity; protein binding; transcription regulatory region DNA binding; gene expression; transcription initiation from RNA polymerase II promoter;
KDM1A	9	nucleus; nucleoplasm; transcription factor complex; chromatin binding; protein binding; transcription regulatory region DNA binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; cell proliferation;
NCOA6	9	nucleus; nucleoplasm; transcription factor complex; chromatin binding; transcription coactivator activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; response to DNA damage stimulus;
GATA6	8	nucleus; nucleoplasm; transcription factor complex; chromatin binding; protein binding; transcription regulatory region DNA binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
NR5A1	8	nucleus; nucleoplasm; chromatin binding; transcription coactivator activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
PSMC3	8	nucleus; nucleoplasm; cytoplasm; transcription coactivator activity; transcription corepressor activity; protein binding; gene expression; cytosol;
SNW1	8	nucleus; nucleoplasm; transcription coactivator activity; transcription corepressor activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
TFAP2A	8	nucleus; cytoplasm; chromatin binding; transcription coactivator activity; protein binding; transcription regulatory region DNA binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
APC	7	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; somatic stem cell maintenance; cytosol; response to DNA damage stimulus;
HES1	7	nucleus; cytoplasm; protein binding; embryonic heart tube morphogenesis; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; positive regulation of cell proliferation;
IRF7	7	nucleus; nucleoplasm; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; cytosol; response to DNA damage stimulus;
MAML1	7	nucleus; nucleoplasm; transcription coactivator activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
MAPK1	7	nucleus; nucleoplasm; cytoplasm; protein binding; positive regulation of cell proliferation; cytosol; response to DNA damage stimulus;
MAPK3	7	nucleus; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; cytosol; response to DNA damage stimulus;
MED12	7	nucleus; nucleoplasm; chromatin binding; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
MED17	7	nucleus; nucleoplasm; transcription factor complex; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
NCOR2	7	nucleus; nucleoplasm; chromatin binding; transcription corepressor activity; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
NEDD4L	7	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter; cytosol;
NR4A2	7	nucleus; nucleoplasm; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
PRKD1	7	nucleus; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; regulation of keratinocyte proliferation; cytosol; cell proliferation;
RBPJ	7	nucleus; nucleoplasm; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
TAF10	7	nucleus; nucleoplasm; cytoplasm; transcription coactivator activity; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
XRCC5	7	nucleus; nucleoplasm; cytoplasm; protein binding; transcription regulatory region DNA binding; negative regulation of apoptotic process; cell proliferation;
E2F5	7	nucleoplasm; transcription factor complex; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
RAN	7	nucleoplasm; cytoplasm; chromatin binding; transcription coactivator activity; protein binding; gene expression; cytosol;
AATF	6	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus;
APBB1	6	nucleus; cytoplasm; chromatin binding; protein binding; response to DNA damage stimulus; proline-rich region binding;
ARRB1	6	nucleus; cytoplasm; protein binding; transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter; cytosol;
CCND1	6	nucleus; nucleoplasm; protein binding; negative regulation of epithelial cell differentiation; cytosol; response to DNA damage stimulus;
EGLN3	6	nucleus; nucleoplasm; cytoplasm; protein binding; cytosol; response to DNA damage stimulus;
ESRRA	6	nucleus; nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
FOXC2	6	nucleus; transcription factor complex; vasculogenesis; transcription regulatory region DNA binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
GSK3B	6	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; cytosol;
HINFP	6	nucleus; nucleoplasm; chromatin binding; transcription coactivator activity; protein binding; transcription regulatory region DNA binding;
HNF1B	6	nucleus; transcription factor complex; protein binding; transcription regulatory region DNA binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
KAT5	6	nucleus; transcription factor complex; transcription coactivator activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; cytosol;
LPIN1	6	nucleus; transcription factor complex; cytoplasm; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; cytosol;
MAML2	6	nucleus; nucleoplasm; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
MAPK7	6	nucleus; nucleoplasm; protein binding; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; cytosol;
MED13	6	nucleus; nucleoplasm; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
MED14	6	nucleus; nucleoplasm; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
MTA2	6	nucleus; transcription factor complex; chromatin binding; protein binding; transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter;
PGR	6	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
PLK1	6	nucleus; nucleoplasm; protein binding; negative regulation of apoptotic process; cytosol; cell proliferation;
POU2F3	6	nucleus; transcription factor complex; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; keratinocyte differentiation;
PRKAA1	6	nucleus; chromatin binding; protein binding; negative regulation of apoptotic process; positive regulation of cell proliferation; cytosol;
PRPF6	6	nucleus; nucleoplasm; transcription coactivator activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression;
RPS3	6	nucleus; cytoplasm; protein binding; gene expression; cytosol; response to DNA damage stimulus;
SMC1A	6	nucleus; nucleoplasm; cytoplasm; chromatin binding; protein binding; gene expression;
SSRP1	6	nucleus; nucleoplasm; cytoplasm; chromatin binding; protein binding; gene expression;
TP53BP1	6	nucleus; nucleoplasm; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; response to DNA damage stimulus;
UBE3A	6	nucleus; cytoplasm; transcription coactivator activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; cytosol;
MED23	6	nucleoplasm; transcription factor complex; transcription coactivator activity; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
MED7	6	nucleoplasm; transcription factor complex; transcription coactivator activity; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
UBB	6	nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter; cytosol;
UBC	6	nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter; cytosol;
ILK	6	cytoplasm; protein binding; positive regulation of cell proliferation; cytosol; cell proliferation; positive regulation of canonical Wnt receptor signaling pathway;
VEGFA	6	cytoplasm; protein binding; vasculogenesis; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation;
AIP	5	nucleus; cytoplasm; transcription coactivator activity; protein binding; cytosol;
ALKBH8	5	nucleus; cytoplasm; protein binding; cytosol; response to DNA damage stimulus;
ATXN1	5	nucleus; nucleoplasm; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter;
BAIAP2	5	nucleus; cytoplasm; protein binding; cytosol; proline-rich region binding;
BARD1	5	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; response to DNA damage stimulus;
BCL9	5	nucleus; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance;
BIRC2	5	nucleus; transcription coactivator activity; protein binding; negative regulation of apoptotic process; cytosol;
BNIP3	5	nucleus; nucleoplasm; cytoplasm; protein binding; negative regulation of apoptotic process;
CBL	5	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; cytosol;
CD2BP2	5	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression;
CHEK1	5	nucleus; nucleoplasm; protein binding; cytosol; response to DNA damage stimulus;
CRYAB	5	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; cytosol;
CTNND1	5	nucleus; cytoplasm; protein binding; keratinocyte differentiation; cytosol;
DCPS	5	nucleus; cytoplasm; protein binding; gene expression; cytosol;
DGCR8	5	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression;
DHX9	5	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression;
EFTUD2	5	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression;
ETS1	5	nucleus; transcription factor complex; protein binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation;
FANCC	5	nucleus; nucleoplasm; cytoplasm; protein binding; cytosol;
FGF10	5	nucleus; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; somatic stem cell maintenance; positive regulation of canonical Wnt receptor signaling pathway;
FGF4	5	nucleus; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation; cytosol;
FLT4	5	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; positive regulation of cell proliferation;
FOXF1	5	nucleus; transcription factor complex; vasculogenesis; transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter;
FOXP1	5	nucleus; transcription factor complex; cytoplasm; chromatin binding; positive regulation of transcription from RNA polymerase II promoter;
FUS	5	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression;
GSTP1	5	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; cytosol;
HEY2	5	nucleus; cytoplasm; protein binding; vasculogenesis; positive regulation of transcription from RNA polymerase II promoter;
HMGA1	5	nucleus; nucleoplasm; transcription factor complex; protein binding; cytosol;
HNRNPA2B1	5	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression;
HNRNPH1	5	nucleus; nucleoplasm; cytoplasm; protein binding; gene expression;
IARS	5	nucleus; cytoplasm; protein binding; gene expression; cytosol;
IRF9	5	nucleus; nucleoplasm; cytoplasm; protein binding; cytosol;
ISL1	5	nucleus; cytoplasm; chromatin binding; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell proliferation;
LATS2	5	nucleus; protein binding; hippo signaling cascade; keratinocyte differentiation; cytosol;
MALT1	5	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; cytosol;
MED15	5	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
MED16	5	nucleus; nucleoplasm; transcription coactivator activity; gene expression; transcription initiation from RNA polymerase II promoter;
MED30	5	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
MED4	5	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
MMS19	5	nucleus; cytoplasm; transcription coactivator activity; protein binding; response to DNA damage stimulus;
MRE11A	5	nucleus; nucleoplasm; protein binding; cell proliferation; response to DNA damage stimulus;
NCBP1	5	nucleus; nucleoplasm; protein binding; gene expression; cytosol;
NCK1	5	nucleus; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; cytosol;
NR4A3	5	nucleus; nucleoplasm; transcription factor complex; gene expression; transcription initiation from RNA polymerase II promoter;
NRIP1	5	nucleus; transcription coactivator activity; transcription corepressor activity; protein binding; positive regulation of transcription from RNA polymerase II promoter;
NUMA1	5	nucleus; nucleoplasm; cytoplasm; protein binding; cytosol;
PRKCB	5	nucleus; cytoplasm; chromatin binding; protein binding; cytosol;
RAD9A	5	nucleus; nucleoplasm; cytoplasm; protein binding; response to DNA damage stimulus;
RCC1	5	nucleus; nucleoplasm; cytoplasm; chromatin binding; protein binding;
RFWD2	5	nucleus; nucleoplasm; cytoplasm; protein binding; cytosol;
SART1	5	nucleus; nucleoplasm; cytoplasm; protein binding; cytosol;
SMARCB1	5	nucleus; nucleoplasm; transcription coactivator activity; protein binding; positive regulation of transcription from RNA polymerase II promoter;
SMARCD3	5	nucleus; nucleoplasm; cytoplasm; transcription coactivator activity; protein binding;
SMC3	5	nucleus; nucleoplasm; cytoplasm; chromatin binding; protein binding;
SMG1	5	nucleus; cytoplasm; protein binding; gene expression; cytosol;
SMG7	5	nucleus; cytoplasm; protein binding; gene expression; cytosol;
SNCA	5	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; cytosol;
SNRPD1	5	nucleus; nucleoplasm; protein binding; gene expression; cytosol;
STRN3	5	nucleus; nucleoplasm; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter;
TAF13	5	nucleus; nucleoplasm; protein binding; gene expression; transcription initiation from RNA polymerase II promoter;
TAF4B	5	nucleus; nucleoplasm; cytoplasm; gene expression; transcription initiation from RNA polymerase II promoter;
TFEB	5	nucleus; transcription factor complex; cytoplasm; transcription regulatory region DNA binding; positive regulation of transcription from RNA polymerase II promoter;
THRAP3	5	nucleus; transcription coactivator activity; protein binding; positive regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter;
TJP1	5	nucleus; cytoplasm; protein binding; hippo signaling cascade; cytosol;
TNFAIP3	5	nucleus; cytoplasm; protein binding; negative regulation of apoptotic process; cytosol;
TRIM32	5	nucleus; cytoplasm; transcription coactivator activity; protein binding; negative regulation of apoptotic process;
TRIP12	5	nucleus; nucleoplasm; cytoplasm; protein binding; response to DNA damage stimulus;
USP28	5	nucleus; nucleoplasm; protein binding; cell proliferation; response to DNA damage stimulus;
WWOX	5	nucleus; cytoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; cytosol;
ATM	5	nucleoplasm; protein binding; negative regulation of apoptotic process; response to DNA damage stimulus; cellular response to gamma radiation;
CBFA2T3	5	nucleoplasm; chromatin binding; protein binding; positive regulation of transcription from RNA polymerase II promoter; cell proliferation;
NR6A1	5	nucleoplasm; transcription factor complex; gene expression; transcription initiation from RNA polymerase II promoter; cell proliferation;
RORA	5	nucleoplasm; protein binding; positive regulation of transcription from RNA polymerase II promoter; gene expression; transcription initiation from RNA polymerase II promoter;
XPO1	5	nucleoplasm; cytoplasm; protein binding; gene expression; cytosol;
NFATC4	5	transcription factor complex; cytoplasm; transcription coactivator activity; positive regulation of transcription from RNA polymerase II promoter; cytosol;
RPS9	5	cytoplasm; protein binding; gene expression; positive regulation of cell proliferation; cytosol;

Genes shared at least 2 KEGG pathways with YAP1 (count: 0)

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Region: chr11:101981192..102104154 View in gBrowse