ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ZNF423
Symbol Alias	KIAA0760, OAZ, Roaz, Ebfaz, Zfp104
Approved Name	zinc finger protein 423
Name Alias	OLF-1/EBF associated zinc finger gene, " Smad- and Olf-interacting zinc finger protein", "early B-cell factor associated zinc finger protein"
Location	16q12
Position	chr16:49524521-49860918, -
External Links	HGNC: 16762 Entrez Gene: 23090 Ensembl: ENSG00000102935 UCSC: uc002efs.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Lasky-Su J, 2008	1 flanking SNPs of this gene with P-value<1E-5.	Trend

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs17281813	Chr16:49750790(Fwd)	intron_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[10660046]	64
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10660046]	80
GO:0003677	DNA binding	Molecular Function		220
GO:0007219	Notch signaling pathway	Biological Process		21
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005634	nucleus	Cellular Component	IDA[10660046]	770
GO:0005515	protein binding	Molecular Function		910
GO:0030513	positive regulation of BMP signaling pathway	Biological Process		5
GO:0030154	cell differentiation	Biological Process		51
GO:0008270	zinc ion binding	Molecular Function		323
GO:0007399	nervous system development	Biological Process		54

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with ZNF423 (count: 28)

Gene Symbol	Pathway Count	Pathway List
HES1	7	negative regulation of transcription, DNA-dependent; DNA binding; Notch signaling pathway; nucleus; protein binding; positive regulation of BMP signaling pathway; nervous system development;
HINFP	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding; zinc ion binding;
ZBTB16	7	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding; zinc ion binding;
HMGA1	6	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding;
RBPJ	6	negative regulation of transcription, DNA-dependent; DNA binding; Notch signaling pathway; nucleus; protein binding; positive regulation of BMP signaling pathway;
ZNF24	6	negative regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding; zinc ion binding;
MYT1L	6	DNA binding; transcription, DNA-dependent; nucleus; cell differentiation; zinc ion binding; nervous system development;
ATXN1	5	negative regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding;
BCLAF1	5	negative regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding;
CCDC85B	5	negative regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; protein binding; cell differentiation;
CREBZF	5	negative regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding;
KAT5	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleus; protein binding;
LHX1	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nucleus; zinc ion binding; nervous system development;
MYB	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; protein binding;
RELA	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA binding; nucleus; protein binding;
RREB1	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA binding; nucleus; zinc ion binding;
RSF1	5	negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; nucleus; protein binding; zinc ion binding;
XRCC5	5	negative regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding;
ZNF263	5	negative regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
ETS1	5	positive regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding;
MAPK1	5	positive regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; protein binding;
ZNF287	5	positive regulation of transcription, DNA-dependent; DNA binding; transcription, DNA-dependent; nucleus; zinc ion binding;
IGHMBP2	5	DNA binding; transcription, DNA-dependent; nucleus; protein binding; zinc ion binding;
NCOR2	5	DNA binding; Notch signaling pathway; transcription, DNA-dependent; nucleus; protein binding;
NR5A1	5	DNA binding; nucleus; protein binding; cell differentiation; zinc ion binding;
ZNF521	5	DNA binding; transcription, DNA-dependent; nucleus; cell differentiation; zinc ion binding;
ZNF646	5	DNA binding; transcription, DNA-dependent; nucleus; protein binding; zinc ion binding;
SMARCB1	5	transcription, DNA-dependent; nucleus; protein binding; cell differentiation; nervous system development;

Genes shared at least 2 KEGG pathways with ZNF423 (count: 0)

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Region: chr16:49524521..49860918 View in gBrowse