ADHDgene Database
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  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005576
Name extracellular region
Type Cellular Component
No. of Genes in ADHDgene  240
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 240)

Literature-origin genes (count: 19)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
NXPH1 neurexophilin 1 7p22 1(0/1/0)
MMP7 matrix metallopeptidase 7 (matrilysin, uterine) 11q21-q22 1(0/0/1)
STX1A syntaxin 1A (brain) 7q11.2 3(2/1/0)
CNTN4 contactin 4 3p26.3 1(1/0/0)
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0) IDA[9811930]
EREG epiregulin 4q21.21 1(0/0/1)
NPPC natriuretic peptide C 2q24-qter 1(0/1/0)
GPX6 glutathione peroxidase 6 (olfactory) 6p22.1 1(0/1/0)
TLL2 tolloid-like 2 10q23-q24 1(0/0/1)
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9q34 20(11/9/0) NAS[14718574]
NTF3 neurotrophin 3 12p13 3(1/2/0)
LECT1 leukocyte cell derived chemotaxin 1 13q14.3 1(0/1/0)
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0)
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4q21.3-q22 1(0/1/0)
FGF10 fibroblast growth factor 10 5p13-p12 1(0/1/0)
BDNF brain-derived neurotrophic factor 11p14.1 14(8/6/0)
VEGFA vascular endothelial growth factor A 6p12 1(0/1/0)
LPL lipoprotein lipase 8p22 1(0/0/1)
GFOD1 glucose-fructose oxidoreductase domain containing 1 6pter-p22.1 1(1/0/0)

Genes from other sources Help (count: 221)

Approved Symbol Approved Name Source Evidence[PMID]
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) Mapped by significant region
FLT4 fms-related tyrosine kinase 4 Mapped by CNV
GPHA2 glycoprotein hormone alpha 2 Mapped by significant region IDA[12089349]
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E Mapped by CNV
TXN thioredoxin Mapped by significant region
NXPH4 neurexophilin 4 Mapped by CNV
PLAC1L placenta-specific 1-like Mapped by significant region
MMP8 matrix metallopeptidase 8 (neutrophil collagenase) Mapped by significant region
C11orf45 chromosome 11 open reading frame 45 Mapped by significant region
C11orf44 chromosome 11 open reading frame 44 Mapped by significant region
IGLL1 immunoglobulin lambda-like polypeptide 1 Mapped by CNV
IGHV1OR15-1 immunoglobulin heavy variable 1/OR15-1 (pseudogene) Mapped by significant region NAS[2841108]
PAPPA pregnancy-associated plasma protein A, pappalysin 1 Mapped by significant region IDA[10077652]; NAS[10913121]
ISM1 isthmin 1 homolog (zebrafish) Mapped by CNV
CHRDL2 chordin-like 2 Mapped by significant region
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) Mapped by CNV
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) Mapped by CNV
CRB2 crumbs homolog 2 (Drosophila) Mapped by significant region
C10orf99 chromosome 10 open reading frame 99 Mapped by CNV
IGFBP5 insulin-like growth factor binding protein 5 Mapped by significant region NAS[14718574]
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 Mapped by significant region
CCL19 chemokine (C-C motif) ligand 19 Mapped by LD-proxy
RESP18 regulated endocrine-specific protein 18 homolog (rat) Mapped by significant region
GP2 glycoprotein 2 (zymogen granule membrane) Mapped by significant region
MASP2 mannan-binding lectin serine peptidase 2 Mapped by literature SNP
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) Mapped by significant region
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) Mapped by significant region
PLA2G5 phospholipase A2, group V Mapped by PBA pathway
CCL27 chemokine (C-C motif) ligand 27 Mapped by LD-proxy
IGFBP2 insulin-like growth factor binding protein 2, 36kDa Mapped by significant region
PRSS53 protease, serine, 53 Mapped by CNV
BTC betacellulin Mapped by CNV
OGN osteoglycin Mapped by significant region
PRSS8 protease, serine, 8 Mapped by CNV TAS[10077646]
BTBD17 BTB (POZ) domain containing 17 Mapped by CNV
REG3G regenerating islet-derived 3 gamma Mapped by CNV
AOAH acyloxyacyl hydrolase (neutrophil) Mapped by PBA pathway
IL7R interleukin 7 receptor Mapped by significant region
SEPP1 selenoprotein P, plasma, 1 Mapped by CNV NAS[14718574]
PATE1 prostate and testis expressed 1 Mapped by significant region
PATE3 prostate and testis expressed 3 Mapped by significant region
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) Mapped by significant region
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 Mapped by CNV; Mapped by significant region
DEAF1 deformed epidermal autoregulatory factor 1 (Drosophila) Mapped by literature SNP
VWA3A von Willebrand factor A domain containing 3A Mapped by CNV; Mapped by significant region
KRTAP5-8 keratin associated protein 5-8 Mapped by significant region
IGF2 insulin-like growth factor 2 (somatomedin A) Mapped by LD-proxy; Mapped by literature SNP
PLA2G4B phospholipase A2, group IVB (cytosolic) Mapped by PBA pathway TAS[10085124]
PRAP1 proline-rich acidic protein 1 Mapped by CNV; Mapped by literature SNP
OMD osteomodulin Mapped by significant region
VWCE von Willebrand factor C and EGF domains Mapped by significant region
DEFB108B defensin, beta 108B Mapped by significant region
GRP gastrin-releasing peptide Mapped by significant region
LAMA2 laminin, alpha 2 Mapped by CNV; Mapped by significant region
DEFB134 defensin, beta 134 Mapped by CNV
DEFB136 defensin, beta 136 Mapped by CNV
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 Mapped by CNV; Mapped by literature SNP
PRSS47 protease, serine, 47 Mapped by significant region
OLFML2B olfactomedin-like 2B Mapped by CNV
CXCL12 chemokine (C-X-C motif) ligand 12 Mapped by PBA pathway
OLFML1 olfactomedin-like 1 Mapped by CNV
OLFML2A olfactomedin-like 2A Mapped by significant region
PRSS23 protease, serine, 23 Mapped by significant region
PYCARD PYD and CARD domain containing Mapped by CNV
SAAL1 serum amyloid A-like 1 Mapped by LD-proxy
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 Mapped by significant region NAS[14718574]
HPX hemopexin Mapped by CNV NAS[14718574]
NBL1 neuroblastoma, suppression of tumorigenicity 1 Mapped by LD-proxy
APOA1 apolipoprotein A-I Mapped by significant region
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 Mapped by significant region NAS[14718574]
GALNT1 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1) Mapped by significant region
EDEM2 ER degradation enhancer, mannosidase alpha-like 2 Mapped by LD-proxy; Mapped by literature SNP
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Mapped by CNV NAS[14718574]
DHRS11 dehydrogenase/reductase (SDR family) member 11 Mapped by CNV
MR1 major histocompatibility complex, class I-related Mapped by significant region
TLL1 tolloid-like 1 Mapped by LD-proxy; Mapped by literature SNP
NPIPL2 nuclear pore complex interacting protein-like 2 Mapped by significant region
ORM1 orosomucoid 1 Mapped by significant region NAS[14718574]
GPX5 glutathione peroxidase 5 (epididymal androgen-related protein) Mapped by LD-proxy
KCP kielin/chordin-like protein Mapped by LD-proxy; Mapped by literature SNP
LIFR leukemia inhibitory factor receptor alpha Mapped by significant region
XYLT1 xylosyltransferase I Mapped by CNV; Mapped by significant region
FGF9 fibroblast growth factor 9 (glia-activating factor) Mapped by significant region
NCAM1 neural cell adhesion molecule 1 Mapped by significant region
GAL galanin prepropeptide Mapped by CNV; Mapped by significant region
CTSG cathepsin G Mapped by significant region
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) Mapped by significant region
KIRREL3 kin of IRRE like 3 (Drosophila) Mapped by significant region
VEGFB vascular endothelial growth factor B Mapped by significant region
CMA1 chymase 1, mast cell Mapped by significant region
PON2 paraoxonase 2 Mapped by PBA pathway
GSN gelsolin Mapped by PBA pathway; Mapped by significant region IDA[3020431]; NAS[14718574]
FGF4 fibroblast growth factor 4 Mapped by significant region
NPY neuropeptide Y Mapped by CNV; Mapped by significant region
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 Mapped by CNV
CTRB1 chymotrypsinogen B1 Mapped by significant region
CTRB2 chymotrypsinogen B2 Mapped by significant region
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 Mapped by CNV
POTEKP POTE ankyrin domain family, member K, pseudogene Mapped by significant region
LIPF lipase, gastric Mapped by PBA pathway
FGF3 fibroblast growth factor 3 Mapped by significant region
ABHD15 abhydrolase domain containing 15 Mapped by LD-proxy
FGF19 fibroblast growth factor 19 Mapped by significant region
NPVF neuropeptide VF precursor Mapped by CNV; Mapped by significant region
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region
PRLR prolactin receptor Mapped by significant region
LGI2 leucine-rich repeat LGI family, member 2 Mapped by CNV
APOA5 apolipoprotein A-V Mapped by significant region IDA[11577099]
HABP4 hyaluronan binding protein 4 Mapped by significant region
PLA2G10 phospholipase A2, group X Mapped by PBA pathway; Mapped by significant region
COL8A1 collagen, type VIII, alpha 1 Mapped by CNV
IL18 interleukin 18 (interferon-gamma-inducing factor) Mapped by significant region
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 Mapped by significant region
CABP4 calcium binding protein 4 Mapped by significant region NAS[16960802]
PDGFD platelet derived growth factor D Mapped by significant region
TSKU tsukushi small leucine rich proteoglycan homolog (Xenopus laevis) Mapped by significant region
ACHE acetylcholinesterase Mapped by PBA pathway IDA[1517212]; TAS[11283752]
DSC3 desmocollin 3 Mapped by significant region
IL18BP interleukin 18 binding protein Mapped by significant region TAS[10023777]
PLA1A phospholipase A1 member A Mapped by PBA pathway
REG1A regenerating islet-derived 1 alpha Mapped by CNV
CLEC3A C-type lectin domain family 3, member A Mapped by significant region
F2RL2 coagulation factor II (thrombin) receptor-like 2 Mapped by PBA pathway
CLEC19A C-type lectin domain family 19, member A Mapped by significant region
SCG5 secretogranin V (7B2 protein) Mapped by CNV; Mapped by significant region
CLEC18B C-type lectin domain family 18, member B Mapped by significant region
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Mapped by significant region
APOA4 apolipoprotein A-IV Mapped by significant region NAS[14718574]
REG1B regenerating islet-derived 1 beta Mapped by CNV
ALDOA aldolase A, fructose-bisphosphate Mapped by CNV
F10 coagulation factor X Mapped by CNV NAS[14718574]
C9orf47 chromosome 9 open reading frame 47 Mapped by significant region
EYS eyes shut homolog (Drosophila) Mapped by significant region
NPC1 Niemann-Pick disease, type C1 Mapped by significant region
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) Mapped by CNV IDA[12782713]
ST14 suppression of tumorigenicity 14 (colon carcinoma) Mapped by significant region
LTBP3 latent transforming growth factor beta binding protein 3 Mapped by significant region
SCGB1D4 secretoglobin, family 1D, member 4 Mapped by significant region
ACP6 acid phosphatase 6, lysophosphatidic Mapped by CNV
CLCF1 cardiotrophin-like cytokine factor 1 Mapped by significant region IDA[10966616]; NAS[10448081]
C6 complement component 6 Mapped by significant region
ARSJ arylsulfatase family, member J Mapped by CNV
C6orf58 chromosome 6 open reading frame 58 Mapped by significant region
PDZD2 PDZ domain containing 2 Mapped by significant region ISS[12671685]
C7 complement component 7 Mapped by significant region
GLB1L galactosidase, beta 1-like Mapped by significant region
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Mapped by significant region
GLB1L2 galactosidase, beta 1-like 2 Mapped by CNV; Mapped by significant region
CTGF connective tissue growth factor Mapped by significant region
C9 complement component 9 Mapped by significant region
TBC1D15 TBC1 domain family, member 15 Mapped by LD-proxy
SCGB3A1 secretoglobin, family 3A, member 1 Mapped by CNV NAS[11481438]
STRCP1 stereocilin pseudogene 1 Mapped by LD-proxy
C5 complement component 5 Mapped by significant region
PLA2G3 phospholipase A2, group III Mapped by PBA pathway
LAMC1 laminin, gamma 1 (formerly LAMB2) Mapped by significant region
PNLIPRP2 pancreatic lipase-related protein 2 Mapped by PBA pathway
CTF1 cardiotrophin 1 Mapped by CNV TAS[7862649]
NMS neuromedin S Mapped by CNV
C4orf26 chromosome 4 open reading frame 26 Mapped by CNV
TTR transthyretin Mapped by significant region NAS[14718574]
PLA2G2E phospholipase A2, group IIE Mapped by PBA pathway
APOL3 apolipoprotein L, 3 Mapped by CNV
NMU neuromedin U Mapped by LD-proxy
MTRNR2L1 MT-RNR2-like 1 Mapped by significant region
PNLIPRP1 pancreatic lipase-related protein 1 Mapped by PBA pathway TAS[1379598]
CST6 cystatin E/M Mapped by significant region
LAMA3 laminin, alpha 3 Mapped by significant region
TUBA4A tubulin, alpha 4a Mapped by significant region
MMP1 matrix metallopeptidase 1 (interstitial collagenase) Mapped by significant region
PLA2G2D phospholipase A2, group IID Mapped by PBA pathway
INHA inhibin, alpha Mapped by significant region TAS[12456957]
FOLR1 folate receptor 1 (adult) Mapped by significant region
TMEM25 transmembrane protein 25 Mapped by significant region
WDR1 WD repeat domain 1 Mapped by CNV
F7 coagulation factor VII (serum prothrombin conversion accelerator) Mapped by CNV
LAMC2 laminin, gamma 2 Mapped by significant region
RSPO3 R-spondin 3 homolog (Xenopus laevis) Mapped by significant region
FOLR2 folate receptor 2 (fetal) Mapped by significant region
C3orf58 chromosome 3 open reading frame 58 Mapped by LD-proxy
MMP10 matrix metallopeptidase 10 (stromelysin 2) Mapped by significant region
FOLR3 folate receptor 3 (gamma) Mapped by significant region
FOLR4 folate receptor 4 (delta) homolog (mouse) Mapped by significant region
TMPRSS11B transmembrane protease, serine 11B Mapped by significant region
APOC3 apolipoprotein C-III Mapped by significant region
PGA4 pepsinogen 4, group I (pepsinogen A) Mapped by significant region
FCRLA Fc receptor-like A Mapped by CNV
ENDOD1 endonuclease domain containing 1 Mapped by significant region
CCDC126 coiled-coil domain containing 126 Mapped by CNV; Mapped by significant region
AMBP alpha-1-microglobulin/bikunin precursor Mapped by significant region NAS[11877257]
WNT6 wingless-type MMTV integration site family, member 6 Mapped by significant region
TMPRSS11A transmembrane protease, serine 11A Mapped by significant region
TMPRSS11D transmembrane protease, serine 11D Mapped by significant region
INS insulin Mapped by literature SNP IC[7556975]
SIAE sialic acid acetylesterase Mapped by significant region
FN1 fibronectin 1 Mapped by significant region NAS[14718574]
MMP11 matrix metallopeptidase 11 (stromelysin 3) Mapped by CNV
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) Mapped by PBA pathway
MMP13 matrix metallopeptidase 13 (collagenase 3) Mapped by significant region
TMPRSS11F transmembrane protease, serine 11F Mapped by significant region
BCHE butyrylcholinesterase Mapped by CNV NAS[14718574]
TMPRSS11E transmembrane protease, serine 11E Mapped by significant region
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin Mapped by CNV
IHH Indian hedgehog Mapped by significant region
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A Mapped by significant region
COL15A1 collagen, type XV, alpha 1 Mapped by significant region
KARS lysyl-tRNA synthetase Mapped by significant region
PLA2G1B phospholipase A2, group IB (pancreas) Mapped by PBA pathway
CES5A carboxylesterase 5A Mapped by LD-proxy
CFC1 cripto, FRL-1, cryptic family 1 Mapped by significant region
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 Mapped by significant region
COL27A1 collagen, type XXVII, alpha 1 Mapped by significant region
C11orf83 chromosome 11 open reading frame 83 Mapped by significant region
PNLIP pancreatic lipase Mapped by PBA pathway
GHR growth hormone receptor Mapped by CNV; Mapped by significant region
CFC1B cripto, FRL-1, cryptic family 1B Mapped by significant region
APOC2 apolipoprotein C-II Mapped by PBA pathway NAS[14718574]
TNC tenascin C Mapped by significant region
COL10A1 collagen, type X, alpha 1 Mapped by significant region
C17orf77 chromosome 17 open reading frame 77 Mapped by CNV
PGA5 pepsinogen 5, group I (pepsinogen A) Mapped by significant region

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Last update: Feb 26, 2014