ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0006508
Name proteolysis
Type Biological Process
No. of Genes in ADHDgene  102
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 102)

Literature-origin genes (count: 7)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
MMP7 matrix metallopeptidase 7 (matrilysin, uterine) 11q21-q22 1(0/0/1)
DPP6 dipeptidyl-peptidase 6 7q36.2 1(1/0/0)
AGBL1 ATP/GTP binding protein-like 1 15q25.3 1(0/0/1)
FURIN furin (paired basic amino acid cleaving enzyme) 15q26.1 1(0/0/1)
NLN neurolysin (metallopeptidase M3 family) 5q12.3 1(1/0/0)
TLL2 tolloid-like 2 10q23-q24 1(0/0/1)
MMP24 matrix metallopeptidase 24 (membrane-inserted) 20q11.2 1(0/0/1)

Genes from other sources Help (count: 95)

Approved Symbol Approved Name Source Evidence[PMID]
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 Mapped by significant region
ADAM8 ADAM metallopeptidase domain 8 Mapped by CNV; Mapped by LD-proxy
RCE1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae) Mapped by significant region TAS[10085068]
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) Mapped by significant region
TASP1 taspase, threonine aspartase, 1 Mapped by CNV
CASP4 caspase 4, apoptosis-related cysteine peptidase Mapped by significant region
CASP12 caspase 12 (gene/pseudogene) Mapped by significant region
MMP8 matrix metallopeptidase 8 (neutrophil collagenase) Mapped by significant region IDA[2164002]
PAPPA pregnancy-associated plasma protein A, pappalysin 1 Mapped by significant region
CASP5 caspase 5, apoptosis-related cysteine peptidase Mapped by significant region
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) Mapped by significant region
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) Mapped by significant region
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) Mapped by CNV
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 Mapped by significant region NAS[10085079]
SEC11C SEC11 homolog C (S. cerevisiae) Mapped by significant region
MMP27 matrix metallopeptidase 27 Mapped by significant region
MASP2 mannan-binding lectin serine peptidase 2 Mapped by literature SNP
FBXW2 F-box and WD repeat domain containing 2 Mapped by significant region TAS[10531035]
ADAM33 ADAM metallopeptidase domain 33 Mapped by CNV NAS[11814695]
MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) Mapped by significant region
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 Mapped by LD-proxy
PRSS8 protease, serine, 8 Mapped by CNV
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 Mapped by significant region
C9orf3 chromosome 9 open reading frame 3 Mapped by significant region IDA[15687497]
PRSS53 protease, serine, 53 Mapped by CNV
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) Mapped by significant region
F10 coagulation factor X Mapped by CNV
ST14 suppression of tumorigenicity 14 (colon carcinoma) Mapped by significant region IDA[19911255]
OTUB1 OTU domain, ubiquitin aldehyde binding 1 Mapped by significant region
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 Mapped by significant region
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 Mapped by significant region
OTUD7A OTU domain containing 7A Mapped by CNV; Mapped by significant region
LONRF2 LON peptidase N-terminal domain and ring finger 2 Mapped by CNV
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 Mapped by CNV; Mapped by significant region
PRSS36 protease, serine, 36 Mapped by CNV
PRSS47 protease, serine, 47 Mapped by significant region
DPP3 dipeptidyl-peptidase 3 Mapped by significant region
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 Mapped by CNV; Mapped by literature SNP
PRCP prolylcarboxypeptidase (angiotensinase C) Mapped by significant region
PRSS23 protease, serine, 23 Mapped by significant region
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 Mapped by significant region IDA[18223652]
UQCRC2 ubiquinol-cytochrome c reductase core protein II Mapped by CNV; Mapped by significant region
ASRGL1 asparaginase like 1 Mapped by significant region
SHFM1 split hand/foot malformation (ectrodactyly) type 1 Mapped by LD-proxy IDA[10373512]
PYCARD PYD and CARD domain containing Mapped by CNV
TLL1 tolloid-like 1 Mapped by LD-proxy; Mapped by literature SNP
ASTL astacin-like metallo-endopeptidase (M12 family) Mapped by LD-proxy IDA[15087446]
TPP1 tripeptidyl peptidase I Mapped by CNV IMP[10965052]
FOLH1B folate hydrolase 1B Mapped by significant region
THOP1 thimet oligopeptidase 1 Mapped by LD-proxy
MMP10 matrix metallopeptidase 10 (stromelysin 2) Mapped by significant region
DPEP1 dipeptidase 1 (renal) Mapped by significant region
F7 coagulation factor VII (serum prothrombin conversion accelerator) Mapped by CNV
MMP1 matrix metallopeptidase 1 (interstitial collagenase) Mapped by significant region
CTSW cathepsin W Mapped by significant region
TMPRSS11A transmembrane protease, serine 11A Mapped by significant region
CTSG cathepsin G Mapped by significant region IDA[11907569]
BLMH bleomycin hydrolase Mapped by CNV; Mapped by LD-proxy
MMP11 matrix metallopeptidase 11 (stromelysin 3) Mapped by CNV
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) Mapped by significant region IDA[12888622]
CPD carboxypeptidase D Mapped by CNV
TRHDE thyrotropin-releasing hormone degrading enzyme Mapped by LD-proxy
TMPRSS11D transmembrane protease, serine 11D Mapped by significant region
TMPRSS11B transmembrane protease, serine 11B Mapped by significant region
CTSF cathepsin F Mapped by significant region
TMPRSS11E transmembrane protease, serine 11E Mapped by significant region
MMP13 matrix metallopeptidase 13 (collagenase 3) Mapped by significant region
CTSL2 cathepsin L2 Mapped by significant region
CMA1 chymase 1, mast cell Mapped by significant region
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 Mapped by significant region
MMP12 matrix metallopeptidase 12 (macrophage elastase) Mapped by significant region
TMPRSS13 transmembrane protease, serine 13 Mapped by significant region
IHH Indian hedgehog Mapped by significant region
CARD17 caspase recruitment domain family, member 17 Mapped by significant region
PYDC1 PYD (pyrin domain) containing 1 Mapped by CNV
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 Mapped by CNV
TMPRSS11F transmembrane protease, serine 11F Mapped by significant region
BACE1 beta-site APP-cleaving enzyme 1 Mapped by significant region IDA[10531052]
MMP16 matrix metallopeptidase 16 (membrane-inserted) Mapped by CNV
CTRB1 chymotrypsinogen B1 Mapped by significant region
TMPRSS5 transmembrane protease, serine 5 Mapped by significant region IMP[17918732]
CAPN5 calpain 5 Mapped by significant region
TMPRSS4 transmembrane protease, serine 4 Mapped by significant region NAS[10825129]
UBE3A ubiquitin protein ligase E3A Mapped by CNV; Mapped by significant region TAS[8221889]
CAPN1 calpain 1, (mu/I) large subunit Mapped by significant region
PCSK7 proprotein convertase subtilisin/kexin type 7 Mapped by significant region
MBTPS1 membrane-bound transcription factor peptidase, site 1 Mapped by CNV; Mapped by significant region
DNPEP aspartyl aminopeptidase Mapped by significant region
CTSC cathepsin C Mapped by significant region IDA[8811434]
PGA5 pepsinogen 5, group I (pepsinogen A) Mapped by significant region
CTRB2 chymotrypsinogen B2 Mapped by significant region
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 Mapped by significant region TAS[9694792]
MEP1B meprin A, beta Mapped by significant region
MMP20 matrix metallopeptidase 20 Mapped by significant region
PGA4 pepsinogen 4, group I (pepsinogen A) Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014