ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0006915
Name	apoptotic process
Type	Biological Process
No. of Genes in ADHDgene	111
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 111)

Literature-origin genes (count: 10)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
TIAM2	T-cell lymphoma invasion and metastasis 2	6q25	1(0/0/1)
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	11p11.2	1(0/0/1)
NGF	nerve growth factor (beta polypeptide)	1p13.1	2(2/0/0)
TRIO	triple functional domain (PTPRF interacting)	5p14-p15.1	1(0/0/1)
PHLDA1	pleckstrin homology-like domain, family A, member 1	12q15	1(0/1/0)
UNC5B	unc-5 homolog B (C. elegans)	10q22.2	1(0/0/1)
ADRB1	adrenergic, beta-1-, receptor	10q24-q26	2(0/2/0)
NET1	neuroepithelial cell transforming 1	10p15	0
KANK2	KN motif and ankyrin repeat domains 2	19p13.2	1(0/1/0)
ADRA1A	adrenergic, alpha-1A-, receptor	8p21.2	3(2/1/0)	TAS[10671514]

Genes from other sources (count: 101)

Approved Symbol	Approved Name	Source	Evidence[PMID]
APBB1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	Mapped by CNV
RNF144B	ring finger protein 144B	Mapped by LD-proxy
TP53AIP1	tumor protein p53 regulated apoptosis inducing protein 1	Mapped by significant region	TAS[11030628]
C11orf82	chromosome 11 open reading frame 82	Mapped by significant region
TAX1BP1	Tax1 (human T-cell leukemia virus type I) binding protein 1	Mapped by significant region
DFNA5	deafness, autosomal dominant 5	Mapped by CNV; Mapped by significant region
GJA1	gap junction protein, alpha 1, 43kDa	Mapped by significant region
CASP5	caspase 5, apoptosis-related cysteine peptidase	Mapped by significant region
SPATA4	spermatogenesis associated 4	Mapped by LD-proxy	IEP[12019456]
TGFBR1	transforming growth factor, beta receptor 1	Mapped by significant region
CASP4	caspase 4, apoptosis-related cysteine peptidase	Mapped by significant region
MAP1S	microtubule-associated protein 1S	Mapped by PBA pathway	IDA[12762840]
MAPK3	mitogen-activated protein kinase 3	Mapped by CNV
GZMH	granzyme H (cathepsin G-like 2, protein h-CCPX)	Mapped by significant region	NAS[2402757]
DNAJB13	DnaJ (Hsp40) homolog, subfamily B, member 13	Mapped by CNV; Mapped by significant region	IEP[12673577]
GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	Mapped by significant region
CXCR2	chemokine (C-X-C motif) receptor 2	Mapped by significant region
WWOX	WW domain containing oxidoreductase	Mapped by significant region
EGLN3	egl nine homolog 3 (C. elegans)	Mapped by LD-proxy; Mapped by literature SNP
GATA6	GATA binding protein 6	Mapped by significant region
BIRC2	baculoviral IAP repeat containing 2	Mapped by significant region
PSMB7	proteasome (prosome, macropain) subunit, beta type, 7	Mapped by significant region
ZBTB16	zinc finger and BTB domain containing 16	Mapped by significant region	NAS[9294197]
PRKD1	protein kinase D1	Mapped by significant region
AATF	apoptosis antagonizing transcription factor	Mapped by CNV
MIEN1	migration and invasion enhancer 1	Mapped by LD-proxy
PSMA8	proteasome (prosome, macropain) subunit, alpha type, 8	Mapped by significant region
KRT18	keratin 18	Mapped by PBA pathway
AATK	apoptosis-associated tyrosine kinase	Mapped by LD-proxy
UBC	ubiquitin C	Mapped by CNV
FGD3	FYVE, RhoGEF and PH domain containing 3	Mapped by significant region
SGK1	serum/glucocorticoid regulated kinase 1	Mapped by significant region
CADM1	cell adhesion molecule 1	Mapped by significant region
BRMS1	breast cancer metastasis suppressor 1	Mapped by significant region
GADD45G	growth arrest and DNA-damage-inducible, gamma	Mapped by significant region
PRKCB	protein kinase C, beta	Mapped by significant region
MAPT	microtubule-associated protein tau	Mapped by LD-proxy; Mapped by PBA pathway
AVEN	apoptosis, caspase activation inhibitor	Mapped by CNV
ARHGEF17	Rho guanine nucleotide exchange factor (GEF) 17	Mapped by significant region
EI24	etoposide induced 2.4 mRNA	Mapped by significant region
RNF130	ring finger protein 130	Mapped by CNV
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	Mapped by significant region
PSMG2	proteasome (prosome, macropain) assembly chaperone 2	Mapped by CNV
GREM1	gremlin 1	Mapped by CNV; Mapped by significant region
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	Mapped by significant region
TJP1	tight junction protein 1 (zona occludens 1)	Mapped by CNV; Mapped by significant region
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Mapped by PBA pathway
BCL7C	B-cell CLL/lymphoma 7C	Mapped by CNV
PSME2	proteasome (prosome, macropain) activator subunit 2 (PA28 beta)	Mapped by significant region
RTN3	reticulon 3	Mapped by significant region
SHF	Src homology 2 domain containing F	Mapped by CNV
TRAF1	TNF receptor-associated factor 1	Mapped by significant region
BAD	BCL2-associated agonist of cell death	Mapped by significant region
RTN4	reticulon 4	Mapped by CNV	NAS[11126360]
MCF2L	MCF.2 cell line derived transforming sequence-like	Mapped by CNV
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	Mapped by CNV	IDA[18371312]; IPI[7954800]
TMEM219	transmembrane protein 219	Mapped by CNV
PSME1	proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)	Mapped by significant region
UBB	ubiquitin B	Mapped by significant region
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	Mapped by CNV; Mapped by significant region
SMNDC1	survival motor neuron domain containing 1	Mapped by PBA pathway
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	Mapped by significant region
TAOK2	TAO kinase 2	Mapped by CNV	NAS[10660600]
API5	apoptosis inhibitor 5	Mapped by PBA pathway
MAPK1	mitogen-activated protein kinase 1	Mapped by LD-proxy
ADORA2A	adenosine A2a receptor	Mapped by CNV	TAS[7818494]
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	Mapped by significant region	TAS[7876192]
PDCL3	phosducin-like 3	Mapped by CNV
POLR2G	polymerase (RNA) II (DNA directed) polypeptide G	Mapped by significant region
DAXX	death-domain associated protein	Mapped by LD-proxy; Mapped by PBA pathway	TAS[15572661]
ARF6	ADP-ribosylation factor 6	Mapped by PBA pathway
ERN2	endoplasmic reticulum to nucleus signaling 2	Mapped by significant region
PMAIP1	phorbol-12-myristate-13-acetate-induced protein 1	Mapped by significant region	IMP[17599062]
PSMD7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	Mapped by significant region
BLID	BH3-like motif containing, cell death inducer	Mapped by significant region
PAK7	p21 protein (Cdc42/Rac)-activated kinase 7	Mapped by CNV
CARD6	caspase recruitment domain family, member 6	Mapped by significant region
DSG3	desmoglein 3	Mapped by significant region
C22orf29	chromosome 22 open reading frame 29	Mapped by CNV
NEK6	NIMA (never in mitosis gene a)-related kinase 6	Mapped by significant region
BIRC6	baculoviral IAP repeat containing 6	Mapped by CNV
GSN	gelsolin	Mapped by PBA pathway; Mapped by significant region
PERP	PERP, TP53 apoptosis effector	Mapped by significant region
PDCD10	programmed cell death 10	Mapped by CNV
G2E3	G2/M-phase specific E3 ubiquitin protein ligase	Mapped by significant region
KLF11	Kruppel-like factor 11	Mapped by significant region
CYFIP2	cytoplasmic FMR1 interacting protein 2	Mapped by significant region	IDA[10449408]
DSG2	desmoglein 2	Mapped by significant region	IDA[17559062]
SQSTM1	sequestosome 1	Mapped by CNV
APC	adenomatous polyposis coli	Mapped by LD-proxy; Mapped by PBA pathway
PSMD5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	Mapped by significant region
ATG5	ATG5 autophagy related 5 homolog (S. cerevisiae)	Mapped by CNV
MAPK7	mitogen-activated protein kinase 7	Mapped by significant region
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region
OPA1	optic atrophy 1 (autosomal dominant)	Mapped by CNV
PDCD7	programmed cell death 7	Mapped by PBA pathway
DSG1	desmoglein 1	Mapped by significant region
BIRC3	baculoviral IAP repeat containing 3	Mapped by significant region
CYCS	cytochrome c, somatic	Mapped by CNV; Mapped by significant region	IDA[8689682]
FADD	Fas (TNFRSF6)-associated via death domain	Mapped by significant region
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	Mapped by LD-proxy	NAS[12054647]