ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0007186
Name	G-protein coupled receptor signaling pathway
Type	Biological Process
No. of Genes in ADHDgene	72
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 72)

Literature-origin genes (count: 20)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
ADRA2A	adrenergic, alpha-2A-, receptor	10q24-q26	12(4/8/0)	ISS[19965390]
HTR1E	5-hydroxytryptamine (serotonin) receptor 1E	6q14-q15	2(2/0/0)	TAS[1608964]
GRM1	glutamate receptor, metabotropic 1	6q24	1(1/0/0)	TAS[7476890]
DRD3	dopamine receptor D3	3q13.3	8(1/7/0)	IDA[7911712]
HTR1B	5-hydroxytryptamine (serotonin) receptor 1B	6q13	13(5/8/0)	TAS[1315531]
ADRA1D	adrenergic, alpha-1D-, receptor	20p13	1(0/1/0)	TAS[1656955]
HTR5A	5-hydroxytryptamine (serotonin) receptor 5A	7q36.1	1(0/1/0)	TAS[7988681]
ADRA1B	adrenergic, alpha-1B-, receptor	5q33.3	2(1/1/0)	TAS[2154750]
LPHN3	latrophilin 3	4q13.1	4(3/0/1)	NAS[10994649]
HTR4	5-hydroxytryptamine (serotonin) receptor 4	5q31-q33	1(1/0/0)	TAS[9351641]
OXER1	oxoeicosanoid (OXE) receptor 1	2p22.1	1(0/0/1)	NAS[12065583]
HTR1A	5-hydroxytryptamine (serotonin) receptor 1A	5q11.2-q13	1(1/0/0)	TAS[1330092]
ADRA2C	adrenergic, alpha-2C-, receptor	4p16.3	7(2/4/1)	TAS[9371698]
ADRA1A	adrenergic, alpha-1A-, receptor	8p21.2	3(2/1/0)	TAS[10860850]
GNAT2	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2	1p13	1(1/0/0)	NAS[2534964]
GNAZ	guanine nucleotide binding protein (G protein), alpha z polypeptide	22q11.1-q11.2	1(0/1/0)	TAS[3129724]
ADRA2B	adrenergic, alpha-2B-, receptor	2q11.1	1(1/0/0)	TAS[2164221]
GPR50	G protein-coupled receptor 50	Xq28	1(0/0/1)	TAS[8647286]
RGS18	regulator of G-protein signaling 18	1q31.2	1(0/1/0)
GPR125	G protein-coupled receptor 125	4p15.31	1(0/1/0)	TAS[15203201]

Genes from other sources (count: 52)

Approved Symbol	Approved Name	Source	Evidence[PMID]
TAAR9	trace amine associated receptor 9 (gene/pseudogene)	Mapped by significant region	TAS[15718104]
CXCR5	chemokine (C-X-C motif) receptor 5	Mapped by significant region	TAS[1425907]
CCR5	chemokine (C-C motif) receptor 5	Mapped by PBA pathway	IMP[19523456]
GNRHR	gonadotropin-releasing hormone receptor	Mapped by significant region	TAS[8386108]
NMU	neuromedin U	Mapped by LD-proxy	TAS[10811630]
APOA1	apolipoprotein A-I	Mapped by significant region	IDA[16443932]
S1PR3	sphingosine-1-phosphate receptor 3	Mapped by significant region	TAS[10617617]
C5	complement component 5	Mapped by significant region	TAS[8898085]
GABBR2	gamma-aminobutyric acid (GABA) B receptor, 2	Mapped by significant region	TAS[9872316]
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	Mapped by CNV	NAS[10907856]
BAI3	brain-specific angiogenesis inhibitor 3	Mapped by significant region	TAS[15203201]
CXCR1	chemokine (C-X-C motif) receptor 1	Mapped by significant region	TAS[8381837]
BCAR1	breast cancer anti-estrogen resistance 1	Mapped by significant region	NAS[10092204]
GNB1L	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	Mapped by CNV	NAS[11072084]
CASR	calcium-sensing receptor	Mapped by PBA pathway	TAS[7759551]
APLNR	apelin receptor	Mapped by significant region	TAS[9792798]
GPSM2	G-protein signaling modulator 2	Mapped by CNV	TAS[8973305]
GNG3	guanine nucleotide binding protein (G protein), gamma 3	Mapped by significant region
EDNRA	endothelin receptor type A	Mapped by PBA pathway	NAS[8611157]
MS4A2	membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)	Mapped by PBA pathway; Mapped by significant region	TAS[9169438]
RXFP3	relaxin/insulin-like family peptide receptor 3	Mapped by significant region	TAS[10806363]
GPRC5C	G protein-coupled receptor, family C, group 5, member C	Mapped by CNV	TAS[10783259]
APLP2	amyloid beta (A4) precursor-like protein 2	Mapped by significant region	NAS[8220435]
C3AR1	complement component 3a receptor 1	Mapped by PBA pathway	TAS[8898085]
GNG10	guanine nucleotide binding protein (G protein), gamma 10	Mapped by significant region
MC2R	melanocortin 2 receptor (adrenocorticotropic hormone)	Mapped by CNV	TAS[1325670]
INS	insulin	Mapped by literature SNP	IDA[9092559]
CXCL12	chemokine (C-X-C motif) ligand 12	Mapped by PBA pathway	TAS[8752280]
XPR1	xenotropic and polytropic retrovirus receptor 1	Mapped by significant region	TAS[9990033]
APOC3	apolipoprotein C-III	Mapped by significant region	IDA[16443932]
SORT1	sortilin 1	Mapped by CNV	IMP[18258592]
SCTR	secretin receptor	Mapped by LD-proxy	TAS[7612008]
CHRM1	cholinergic receptor, muscarinic 1	Mapped by PBA pathway; Mapped by significant region	TAS[7925360]
GPR52	G protein-coupled receptor 52	Mapped by significant region	TAS[9931487]
BDKRB2	bradykinin receptor B2	Mapped by PBA pathway	TAS[1314587]
GPR21	G protein-coupled receptor 21	Mapped by significant region	TAS[9073069]
RASD1	RAS, dexamethasone-induced 1	Mapped by significant region	TAS[10840027]
ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	Mapped by CNV; Mapped by significant region	IMP[16443932]
LPAR1	lysophosphatidic acid receptor 1	Mapped by significant region	TAS[8922387]
TAAR1	trace amine associated receptor 1	Mapped by significant region	TAS[15718104]
TAAR2	trace amine associated receptor 2	Mapped by significant region	TAS[15718104]
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	Mapped by significant region	TAS[8530500]
PIK3CG	phosphoinositide-3-kinase, catalytic, gamma polypeptide	Mapped by CNV	IDA[12507995]
GPR144	G protein-coupled receptor 144	Mapped by significant region	TAS[15203201]
LTB4R	leukotriene B4 receptor	Mapped by significant region	TAS[9177352]
TAAR5	trace amine associated receptor 5	Mapped by significant region	TAS[15718104]
GPR139	G protein-coupled receptor 139	Mapped by significant region	IDA[15845401]
CHRM3	cholinergic receptor, muscarinic 3	Mapped by CNV; Mapped by PBA pathway	TAS[9603968]
ARHGEF12	Rho guanine nucleotide exchange factor (GEF) 12	Mapped by significant region	IDA[15755723]
GPR123	G protein-coupled receptor 123	Mapped by CNV	TAS[15203201]
TAAR6	trace amine associated receptor 6	Mapped by significant region	TAS[15718104]
TAAR8	trace amine associated receptor 8	Mapped by significant region	TAS[15718104]