ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007411
Name axon guidance
Type Biological Process
No. of Genes in ADHDgene  65
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 65)

Literature-origin genes (count: 14)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
NRXN1 neurexin 1 2p16.3 1(0/1/0) TAS[1621094]
UNC5B unc-5 homolog B (C. elegans) 10q22.2 1(0/0/1)
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0)
NTF3 neurotrophin 3 12p13 3(1/2/0)
ITGA1 integrin, alpha 1 5q11.1 1(0/1/0)
TRIO triple functional domain (PTPRF interacting) 5p14-p15.1 1(0/0/1)
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 10q21 1(0/1/0)
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 12q13.13 1(0/0/1)
SLIT1 slit homolog 1 (Drosophila) 10q23.3-q24 1(0/0/1) IDA[11748139]
CNTN4 contactin 4 3p26.3 1(1/0/0) TAS[15106122]
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
GDNF glial cell derived neurotrophic factor 5p13.1-p12 2(1/1/0)
BDNF brain-derived neurotrophic factor 11p14.1 14(8/6/0)
CLASP2 cytoplasmic linker associated protein 2 3p24.3 1(0/0/1)

Genes from other sources Help (count: 51)

Approved Symbol Approved Name Source Evidence[PMID]
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit Mapped by PBA pathway
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) Mapped by LD-proxy
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV
CFL1 cofilin 1 (non-muscle) Mapped by significant region
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) Mapped by CNV
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) Mapped by significant region NAS[15105459]
TRPC1 transient receptor potential cation channel, subfamily C, member 1 Mapped by PBA pathway
LAMC1 laminin, gamma 1 (formerly LAMB2) Mapped by significant region
NCK1 NCK adaptor protein 1 Mapped by PBA pathway
SCN3B sodium channel, voltage-gated, type III, beta Mapped by significant region
CNTN6 contactin 6 Mapped by CNV
NCK2 NCK adaptor protein 2 Mapped by PBA pathway
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 Mapped by significant region
PLA2G10 phospholipase A2, group X Mapped by PBA pathway; Mapped by significant region IDA[15927955]
FES feline sarcoma oncogene Mapped by LD-proxy
CLASP1 cytoplasmic linker associated protein 1 Mapped by PBA pathway
EPHA5 EPH receptor A5 Mapped by CNV; Mapped by significant region
NR4A3 nuclear receptor subfamily 4, group A, member 3 Mapped by significant region
SPTBN2 spectrin, beta, non-erythrocytic 2 Mapped by significant region
NCAM1 neural cell adhesion molecule 1 Mapped by significant region
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit Mapped by PBA pathway
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
CACNB4 calcium channel, voltage-dependent, beta 4 subunit Mapped by PBA pathway
CACNB2 calcium channel, voltage-dependent, beta 2 subunit Mapped by PBA pathway
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway
TRPC6 transient receptor potential cation channel, subfamily C, member 6 Mapped by significant region
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Mapped by LD-proxy
MYH11 myosin, heavy chain 11, smooth muscle Mapped by CNV; Mapped by significant region
FEZ1 fasciculation and elongation protein zeta 1 (zygin I) Mapped by significant region TAS[9096408]
CACNB1 calcium channel, voltage-dependent, beta 1 subunit Mapped by PBA pathway
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 Mapped by significant region
CACNB3 calcium channel, voltage-dependent, beta 3 subunit Mapped by PBA pathway
TUBB3 tubulin, beta 3 Mapped by significant region
STIP1 stress-induced-phosphoprotein 1 Mapped by significant region
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy
TRPC5 transient receptor potential cation channel, subfamily C, member 5 Mapped by PBA pathway
TNR tenascin R (restrictin, janusin) Mapped by significant region NAS[8940128]
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit Mapped by PBA pathway
LHX2 LIM homeobox 2 Mapped by significant region
CDH4 cadherin 4, type 1, R-cadherin (retinal) Mapped by CNV
TRPC4 transient receptor potential cation channel, subfamily C, member 4 Mapped by PBA pathway
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit Mapped by CNV
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D Mapped by significant region
CHL1 cell adhesion molecule with homology to L1CAM (close homolog of L1) Mapped by CNV
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 Mapped by significant region
WASL Wiskott-Aldrich syndrome-like Mapped by CNV
LAMA2 laminin, alpha 2 Mapped by CNV; Mapped by significant region
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 Mapped by significant region
TRPC3 transient receptor potential cation channel, subfamily C, member 3 Mapped by PBA pathway
DPYSL4 dihydropyrimidinase-like 4 Mapped by CNV
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E Mapped by CNV

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014