ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

GO Report

Basic Info

ID	GO:0020037
Name	heme binding
Type	Molecular Function
No. of Genes in ADHDgene	23
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 23)

Literature-origin genes (count: 5)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
FADS1	fatty acid desaturase 1	11q12-q13.1	3(1/2/0)
TDO2	tryptophan 2,3-dioxygenase	4q31-q32	1(1/0/0)
PGRMC2	progesterone receptor membrane component 2	4q26	1(0/1/0)
FADS2	fatty acid desaturase 2	11q12.2	3(3/0/0)
NOS1	nitric oxide synthase 1 (neuronal)	12q14-qter	1(1/0/0)

Genes from other sources (count: 18)

Approved Symbol	Approved Name	Source	Evidence[PMID]
FECH	ferrochelatase	Mapped by significant region
FADS3	fatty acid desaturase 3	Mapped by LD-proxy; Mapped by significant region
PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	Mapped by significant region
NOX4	NADPH oxidase 4	Mapped by significant region	TAS[10869423]
DUOX2	dual oxidase 2	Mapped by CNV
CYP27A1	cytochrome P450, family 27, subfamily A, polypeptide 1	Mapped by significant region
AMBP	alpha-1-microglobulin/bikunin precursor	Mapped by significant region	IDA[11877257]
GUCY1A2	guanylate cyclase 1, soluble, alpha 2	Mapped by significant region
ABCB6	ATP-binding cassette, sub-family B (MDR/TAP), member 6	Mapped by significant region	IDA[17006453]
CYB5B	cytochrome b5 type B (outer mitochondrial membrane)	Mapped by CNV
HERC2	hect domain and RLD 2	Mapped by significant region
SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	Mapped by significant region
HBG2	hemoglobin, gamma G	Mapped by CNV
FA2H	fatty acid 2-hydroxylase	Mapped by significant region
CYP2E1	cytochrome P450, family 2, subfamily E, polypeptide 1	Mapped by CNV	IDA[18818195]
DUOX1	dual oxidase 1	Mapped by CNV
CYCS	cytochrome c, somatic	Mapped by CNV; Mapped by significant region	TAS[9515723]
CYBA	cytochrome b-245, alpha polypeptide	Mapped by significant region