ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

GO Report

Basic Info

ID	GO:0031625
Name	ubiquitin protein ligase binding
Type	Molecular Function
No. of Genes in ADHDgene	23
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 23)

Literature-origin genes (count: 4)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)
ARRB2	arrestin, beta 2	17p13	1(1/0/0)	IPI[19372219]
ARRB1	arrestin, beta 1	11q13	2(1/1/0)	IPI[15878855]
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	6q25.2-q27	1(1/0/0)

Genes from other sources (count: 19)

Approved Symbol	Approved Name	Source	Evidence[PMID]
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Mapped by significant region	IPI[8666824]
NEDD8	neural precursor cell expressed, developmentally down-regulated 8	Mapped by significant region	IPI[15694336]
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	Mapped by significant region
OTUB1	OTU domain, ubiquitin aldehyde binding 1	Mapped by significant region
UBXN1	UBX domain protein 1	Mapped by significant region	IDA[18775313]
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	Mapped by CNV
CUL5	cullin 5	Mapped by PBA pathway; Mapped by significant region	IDA[17636018]
RNF40	ring finger protein 40	Mapped by CNV	IPI[16307923]
PDE4D	phosphodiesterase 4D, cAMP-specific	Mapped by CNV	IPI[19372219]
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IPI[12748188]
TRAF1	TNF receptor-associated factor 1	Mapped by significant region	IPI[11279055]
HERC2	hect domain and RLD 2	Mapped by significant region
MC4R	melanocortin 4 receptor	Mapped by significant region	IPI[19737927]
MC1R	melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)	Mapped by significant region	IPI[19737927]
DAXX	death-domain associated protein	Mapped by LD-proxy; Mapped by PBA pathway	IPI[16845383]
FZD4	frizzled family receptor 4	Mapped by significant region
USP2	ubiquitin specific peptidase 2	Mapped by significant region	IPI[17290220]
RNF20	ring finger protein 20	Mapped by significant region	IPI[16307923]
MID1	midline 1 (Opitz/BBB syndrome)	Mapped by PBA pathway	IPI[17438131]