ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0035556
Name	intracellular signal transduction
Type	Biological Process
No. of Genes in ADHDgene	44
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 44)

Literature-origin genes (count: 9)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
PLCL1	phospholipase C-like 1	2q33	1(0/0/1)
DUSP1	dual specificity phosphatase 1	5q35.1	1(0/1/0)
DCDC2	doublecortin domain containing 2	6p22.1	1(1/0/0)
DCLK2	doublecortin-like kinase 2	4q31.3	1(0/0/1)
PPP1R1B	protein phosphatase 1, regulatory (inhibitor) subunit 1B	17	1(0/1/0)
DCLK1	doublecortin-like kinase 1	13q13.3	1(1/0/0)
DGKH	diacylglycerol kinase, eta	13q13.3	1(1/0/0)
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)	IDA[14749367]
SH3BP5	SH3-domain binding protein 5 (BTK-associated)	3p24.3	1(0/0/1)	IDA[10339589]

Genes from other sources (count: 35)

Approved Symbol	Approved Name	Source	Evidence[PMID]
ZP4	zona pellucida glycoprotein 4	Mapped by CNV	IMP[18667750]
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	Mapped by CNV	TAS[2851102]
CDC42BPG	CDC42 binding protein kinase gamma (DMPK-like)	Mapped by significant region
AKAP7	A kinase (PRKA) anchor protein 7	Mapped by significant region	TAS[10613906]
SHC3	SHC (Src homology 2 domain containing) transforming protein 3	Mapped by significant region
SIPA1	signal-induced proliferation-associated 1	Mapped by significant region	NAS[9346962]
RALGPS1	Ral GEF with PH domain and SH3 binding motif 1	Mapped by significant region	NAS[10747847]
PLA2G4C	phospholipase A2, group IVC (cytosolic, calcium-independent)	Mapped by PBA pathway	NAS[10085124]
STAC3	SH3 and cysteine rich domain 3	Mapped by CNV
SQSTM1	sequestosome 1	Mapped by CNV	TAS[8650207]
CTGF	connective tissue growth factor	Mapped by significant region
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	Mapped by significant region
PLCB2	phospholipase C, beta 2	Mapped by PBA pathway
RASA1	RAS p21 protein activator (GTPase activating protein) 1	Mapped by PBA pathway	NAS[1581965]
PRKCB	protein kinase C, beta	Mapped by significant region
SDCBP2	syndecan binding protein (syntenin) 2	Mapped by LD-proxy; Mapped by literature SNP	NAS[11152476]
CORO2A	coronin, actin binding protein, 2A	Mapped by significant region	TAS[8985118]
GUCY1A2	guanylate cyclase 1, soluble, alpha 2	Mapped by significant region
STMN1	stathmin 1	Mapped by PBA pathway	TAS[2917975]
ADCY4	adenylate cyclase 4	Mapped by significant region
UNC13C	unc-13 homolog C (C. elegans)	Mapped by CNV
GNB1L	guanine nucleotide binding protein (G protein), beta polypeptide 1-like	Mapped by CNV	NAS[11072084]
IGFBP5	insulin-like growth factor binding protein 5	Mapped by significant region
PDZD8	PDZ domain containing 8	Mapped by LD-proxy
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	Mapped by CNV; Mapped by significant region
CRKL	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	Mapped by CNV	TAS[8361759]
SH2B3	SH2B adaptor protein 3	Mapped by LD-proxy
ROCK2	Rho-associated, coiled-coil containing protein kinase 2	Mapped by significant region
DEF8	differentially expressed in FDCP 8 homolog (mouse)	Mapped by significant region
PLCD1	phospholipase C, delta 1	Mapped by PBA pathway
PLCD4	phospholipase C, delta 4	Mapped by significant region
ASB15	ankyrin repeat and SOCS box containing 15	Mapped by CNV
ITK	IL2-inducible T-cell kinase	Mapped by significant region
CNIH2	cornichon homolog 2 (Drosophila)	Mapped by significant region
SHANK2	SH3 and multiple ankyrin repeat domains 2	Mapped by significant region