ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0042803
Name	protein homodimerization activity
Type	Molecular Function
No. of Genes in ADHDgene	113
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 113)

Literature-origin genes (count: 17)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	2q37	1(0/0/1)
FOXP2	forkhead box P2	7q31	1(1/0/0)	IDA[16407075]
NTRK2	neurotrophic tyrosine kinase, receptor, type 2	9q22.1	1(1/0/0)
MAOB	monoamine oxidase B	Xp11.4-p11.3	6(2/4/0)
GDNF	glial cell derived neurotrophic factor	5p13.1-p12	2(1/1/0)	IDA[8988018]
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	17q11.2	25(13/12/0)
ADRA2A	adrenergic, alpha-2A-, receptor	10q24-q26	12(4/8/0)	IDA[16605244]
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	2p16.1	1(0/0/1)	TAS[19616629]
NPPC	natriuretic peptide C	2q24-qter	1(0/1/0)
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)
ASMT	acetylserotonin O-methyltransferase	Xp22.3 and Yp11.3	1(1/0/0)
CHRNA7	cholinergic receptor, nicotinic, alpha 7	15q13.3	2(0/1/1)	IDA[8145738]
ADRA2C	adrenergic, alpha-2C-, receptor	4p16.3	7(2/4/1)	IDA[16605244]
ADRB3	adrenergic, beta-3-, receptor	8p12	2(0/2/0)	IDA[15123695]
HES1	hairy and enhancer of split 1, (Drosophila)	3q28-q29	1(1/0/0)
ADRB2	adrenergic, beta-2-, receptor, surface	5q31-q32	2(1/1/0)	IDA[15123695]
FOXP1	forkhead box P1	3p14.1	1(0/0/1)

Genes from other sources (count: 96)

Approved Symbol	Approved Name	Source	Evidence[PMID]
OXCT1	3-oxoacid CoA transferase 1	Mapped by significant region	NAS[10964512]
DSCAML1	Down syndrome cell adhesion molecule like 1	Mapped by significant region	IDA[11453658]
ACAT1	acetyl-CoA acetyltransferase 1	Mapped by CNV; Mapped by significant region
VIL1	villin 1	Mapped by significant region	IDA[17606613]
FBXO4	F-box protein 4	Mapped by significant region
ZBTB16	zinc finger and BTB domain containing 16	Mapped by significant region	IDA[8622986]
SQSTM1	sequestosome 1	Mapped by CNV
TARS	threonyl-tRNA synthetase	Mapped by significant region	NAS[2033077]
PDE2A	phosphodiesterase 2A, cGMP-stimulated	Mapped by significant region	IPI[19828435]
MGLL	monoglyceride lipase	Mapped by PBA pathway	IPI[19957260]
APOA4	apolipoprotein A-IV	Mapped by significant region	IDA[1935934]
DARS2	aspartyl-tRNA synthetase 2, mitochondrial	Mapped by significant region	IPI[15779907]
SCARB1	scavenger receptor class B, member 1	Mapped by CNV
UGT1A8	UDP glucuronosyltransferase 1 family, polypeptide A8	Mapped by LD-proxy; Mapped by literature SNP
TIMM10	translocase of inner mitochondrial membrane 10 homolog (yeast)	Mapped by significant region	IPI[16387659]
DGAT2	diacylglycerol O-acyltransferase 2	Mapped by significant region
SLC39A13	solute carrier family 39 (zinc transporter), member 13	Mapped by LD-proxy
PTS	6-pyruvoyltetrahydropterin synthase	Mapped by significant region
UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	Mapped by LD-proxy; Mapped by literature SNP
HNF1B	HNF1 homeobox B	Mapped by CNV	IPI[1677179]
ATIC	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Mapped by significant region	IPI[14966129]
ANKS6	ankyrin repeat and sterile alpha motif domain containing 6	Mapped by significant region
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	Mapped by significant region
ACHE	acetylcholinesterase	Mapped by PBA pathway	IPI[12524166]; NAS[1517212]
KLHL7	kelch-like 7 (Drosophila)	Mapped by significant region
UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	Mapped by LD-proxy
SUMF1	sulfatase modifying factor 1	Mapped by CNV
UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	Mapped by LD-proxy
NRBP1	nuclear receptor binding protein 1	Mapped by PBA pathway
CADM1	cell adhesion molecule 1	Mapped by significant region	ISS[12826663]
DAB2IP	DAB2 interacting protein	Mapped by significant region	IPI[12813029]
NR6A1	nuclear receptor subfamily 6, group A, member 1	Mapped by significant region
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	Mapped by significant region
UGT1A10	UDP glucuronosyltransferase 1 family, polypeptide A10	Mapped by LD-proxy; Mapped by literature SNP
TRIM5	tripartite motif containing 5	Mapped by CNV	IPI[11331580]
GOPC	golgi-associated PDZ and coiled-coil motif containing	Mapped by significant region
PVRL1	poliovirus receptor-related 1 (herpesvirus entry mediator C)	Mapped by significant region
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	Mapped by LD-proxy
BARD1	BRCA1 associated RING domain 1	Mapped by significant region	IPI[15265711]
PLEKHB1	pleckstrin homology domain containing, family B (evectins) member 1	Mapped by CNV; Mapped by significant region
RCHY1	ring finger and CHY zinc finger domain containing 1	Mapped by CNV	IPI[19483087]
XPA	xeroderma pigmentosum, complementation group A	Mapped by significant region	IPI[8197175]
CHKA	choline kinase alpha	Mapped by significant region
OLFML2A	olfactomedin-like 2A	Mapped by significant region
TPD52L1	tumor protein D52-like 1	Mapped by significant region	IDA[9484778]
CACYBP	calcyclin binding protein	Mapped by significant region	IPI[16085652]
PLD6	phospholipase D family, member 6	Mapped by significant region	IDA[17028579]
ROBO3	roundabout, axon guidance receptor, homolog 3 (Drosophila)	Mapped by significant region
PYCARD	PYD and CARD domain containing	Mapped by CNV	IDA[15030775]
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	Mapped by significant region
RNF40	ring finger protein 40	Mapped by CNV	IPI[10944455]
CORO1A	coronin, actin binding protein, 1A	Mapped by CNV	IDA[15601263]
KCNN2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	Mapped by LD-proxy	IPI[17110593]
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mapped by significant region	IDA[8537108]
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	Mapped by CNV	IDA[9396766]
SYT10	synaptotagmin X	Mapped by CNV
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	Mapped by LD-proxy
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV	TAS[7559606]
MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	Mapped by significant region	IDA[11313484]
CUBN	cubilin (intrinsic factor-cobalamin receptor)	Mapped by CNV	IDA[10552972]
GOLGA5	golgin A5	Mapped by PBA pathway	IPI[9915833]
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	Mapped by PBA pathway
JAM3	junctional adhesion molecule 3	Mapped by significant region
CRYM	crystallin, mu	Mapped by significant region	IDA[12590647]
TBX1	T-box 1	Mapped by CNV	IDA[11111039]
MTMR2	myotubularin related protein 2	Mapped by significant region
PEX7	peroxisomal biogenesis factor 7	Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region	IDA[11931631]
CRYL1	crystallin, lambda 1	Mapped by significant region	IPI[15809331]
CEP57	centrosomal protein 57kDa	Mapped by significant region	IPI[12717444]
SETMAR	SET domain and mariner transposase fusion gene	Mapped by CNV
MAP3K11	mitogen-activated protein kinase kinase kinase 11	Mapped by significant region	IPI[9829970]
PRLR	prolactin receptor	Mapped by significant region	NAS[10585417]
THRSP	thyroid hormone responsive	Mapped by significant region
GHR	growth hormone receptor	Mapped by CNV; Mapped by significant region	IDA[8137822]
ABCG4	ATP-binding cassette, sub-family G (WHITE), member 4	Mapped by significant region	IDA[16870176]
DAXX	death-domain associated protein	Mapped by LD-proxy; Mapped by PBA pathway	IDA[10698492]
FZD4	frizzled family receptor 4	Mapped by significant region	IPI[14688793]
CRYBA2	crystallin, beta A2	Mapped by significant region
VEGFB	vascular endothelial growth factor B	Mapped by significant region
APOC2	apolipoprotein C-II	Mapped by PBA pathway	IMP[8245722]
ACTN3	actinin, alpha 3	Mapped by significant region	TAS[15841212]
ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2	Mapped by CNV	IDA[16870176]
HSF2	heat shock transcription factor 2	Mapped by significant region
SHMT1	serine hydroxymethyltransferase 1 (soluble)	Mapped by significant region	IDA[9753690]
SDCBP2	syndecan binding protein (syntenin) 2	Mapped by LD-proxy; Mapped by literature SNP	IDA[11152476]
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase 1	Mapped by significant region	IDA[7830796]
PDCD10	programmed cell death 10	Mapped by CNV
TYR	tyrosinase (oculocutaneous albinism IA)	Mapped by significant region
SNRPC	small nuclear ribonucleoprotein polypeptide C	Mapped by PBA pathway	IPI[8532530]
CRYAB	crystallin, alpha B	Mapped by significant region	IPI[19646995]
MAP3K5	mitogen-activated protein kinase kinase kinase 5	Mapped by LD-proxy; Mapped by significant region	IDA[11920685]
NPR3	natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)	Mapped by significant region
CCDC88A	coiled-coil domain containing 88A	Mapped by PBA pathway	IPI[16139227]
AMBP	alpha-1-microglobulin/bikunin precursor	Mapped by significant region	IPI[11883904]
MVD	mevalonate (diphospho) decarboxylase	Mapped by significant region	IDA[8626466]
QPRT	quinolinate phosphoribosyltransferase	Mapped by CNV	IDA[17868694]