ADHDgene Database
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  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0044281
Name small molecule metabolic process
Type Biological Process
No. of Genes in ADHDgene  248
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 248)

Literature-origin genes (count: 35)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
TIAM2 T-cell lymphoma invasion and metastasis 2 6q25 1(0/0/1)
STX1A syntaxin 1A (brain) 7q11.2 3(2/1/0)
GPC6 glypican 6 13q32 1(0/0/1)
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 2q37 1(0/0/1)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 7p11 6(5/1/0)
GPC5 glypican 5 13q32 1(0/0/1)
AANAT aralkylamine N-acetyltransferase 17q25 1(0/0/1)
STS steroid sulfatase (microsomal), isozyme S Xp22.32 3(2/1/0)
MAOA monoamine oxidase A Xp11.4-p11.3 20(13/7/0)
MAOB monoamine oxidase B Xp11.4-p11.3 6(2/4/0)
TDO2 tryptophan 2,3-dioxygenase 4q31-q32 1(1/0/0)
HK1 hexokinase 1 10q22 1(0/1/0)
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9q34 20(11/9/0)
NAPRT1 nicotinate phosphoribosyltransferase domain containing 1 8q24.3 1(0/0/1)
ASMT acetylserotonin O-methyltransferase Xp22.3 and Yp11.3 1(1/0/0)
NADSYN1 NAD synthetase 1 11q13.4 1(0/0/1)
FADS2 fatty acid desaturase 2 11q12.2 3(3/0/0)
DHCR7 7-dehydrocholesterol reductase 11q13.4 1(0/0/1)
COMT catechol-O-methyltransferase 22q11.21 25(5/20/0)
TPH1 tryptophan hydroxylase 1 11p15.3-p14 6(2/4/0)
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1p36.3 1(0/1/0)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17pter-p12 2(0/2/0)
TPH2 tryptophan hydroxylase 2 12q15 10(7/3/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
HAS3 hyaluronan synthase 3 16q22.1 1(0/0/1)
ADRA2A adrenergic, alpha-2A-, receptor 10q24-q26 12(4/8/0)
TH tyrosine hydroxylase 11p15.5 7(2/5/0)
ELOVL6 ELOVL fatty acid elongase 6 4q25 1(0/0/1)
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 7q35-q36 1(0/0/1)
ADRA2C adrenergic, alpha-2C-, receptor 4p16.3 7(2/4/1)
PNMT phenylethanolamine N-methyltransferase 17q 3(2/1/0)
FADS1 fatty acid desaturase 1 11q12-q13.1 3(1/2/0)
SNAP25 synaptosomal-associated protein, 25kDa 20p12-p11.2 18(13/5/0)
LPL lipoprotein lipase 8p22 1(0/0/1)
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 11p11.2 1(0/0/1)

Genes from other sources Help (count: 213)

Approved Symbol Approved Name Source Evidence[PMID]
AGXT2 alanine--glyoxylate aminotransferase 2 Mapped by significant region
OXCT1 3-oxoacid CoA transferase 1 Mapped by significant region
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 Mapped by significant region
ARG1 arginase, liver Mapped by significant region
PAOX polyamine oxidase (exo-N4-amino) Mapped by CNV
TXN thioredoxin Mapped by significant region
PANK2 pantothenate kinase 2 Mapped by CNV
CPT1A carnitine palmitoyltransferase 1A (liver) Mapped by CNV; Mapped by significant region
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa Mapped by significant region
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 Mapped by significant region
CHPF chondroitin polymerizing factor Mapped by significant region
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) Mapped by significant region
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) Mapped by PBA pathway
SEC11C SEC11 homolog C (S. cerevisiae) Mapped by significant region
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Mapped by significant region
SRD5A3 steroid 5 alpha-reductase 3 Mapped by LD-proxy
ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 Mapped by PBA pathway
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 Mapped by significant region
PTS 6-pyruvoyltetrahydropterin synthase Mapped by significant region
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial Mapped by LD-proxy
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase Mapped by CNV
DGAT2 diacylglycerol O-acyltransferase 2 Mapped by significant region
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Mapped by significant region
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) Mapped by LD-proxy
OGN osteoglycin Mapped by significant region
LPCAT1 lysophosphatidylcholine acyltransferase 1 Mapped by LD-proxy
HIBADH 3-hydroxyisobutyrate dehydrogenase Mapped by significant region
NDUFC2 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa Mapped by significant region
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) Mapped by PBA pathway
PHKG2 phosphorylase kinase, gamma 2 (testis) Mapped by CNV
PNPLA8 patatin-like phospholipase domain containing 8 Mapped by PBA pathway
ODC1 ornithine decarboxylase 1 Mapped by significant region
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 Mapped by LD-proxy
LPCAT4 lysophosphatidylcholine acyltransferase 4 Mapped by CNV
PLA2G5 phospholipase A2, group V Mapped by PBA pathway
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 Mapped by CNV
UGT1A4 UDP glucuronosyltransferase 1 family, polypeptide A4 Mapped by LD-proxy
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 Mapped by PBA pathway
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa Mapped by significant region
FBP2 fructose-1,6-bisphosphatase 2 Mapped by significant region
MOCOS molybdenum cofactor sulfurase Mapped by significant region
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa Mapped by significant region
OMD osteomodulin Mapped by significant region
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa Mapped by CNV
FBP1 fructose-1,6-bisphosphatase 1 Mapped by significant region
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial Mapped by CNV
PI4K2B phosphatidylinositol 4-kinase type 2 beta Mapped by CNV
CHKA choline kinase alpha Mapped by significant region
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 Mapped by CNV; Mapped by significant region
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha Mapped by CNV
PLA2G4B phospholipase A2, group IVB (cytosolic) Mapped by PBA pathway
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme Mapped by significant region
UPB1 ureidopropionase, beta Mapped by CNV
PC pyruvate carboxylase Mapped by significant region
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mapped by CNV
DHFRP1 dihydrofolate reductase pseudogene 1 Mapped by significant region
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 Mapped by CNV
APRT adenine phosphoribosyltransferase Mapped by significant region
CUBN cubilin (intrinsic factor-cobalamin receptor) Mapped by CNV
ALAD aminolevulinate dehydratase Mapped by significant region
PLD1 phospholipase D1, phosphatidylcholine-specific Mapped by PBA pathway
GALNS galactosamine (N-acetyl)-6-sulfate sulfatase Mapped by significant region
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Mapped by significant region
NUP155 nucleoporin 155kDa Mapped by significant region
ADCY4 adenylate cyclase 4 Mapped by significant region
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 Mapped by CNV
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 Mapped by LD-proxy; Mapped by significant region
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 Mapped by significant region
COX4I1 cytochrome c oxidase subunit IV isoform 1 Mapped by significant region
NEU3 sialidase 3 (membrane sialidase) Mapped by significant region
RGL1 ral guanine nucleotide dissociation stimulator-like 1 Mapped by significant region
SC5DL sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like Mapped by significant region
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) Mapped by significant region
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 Mapped by significant region
NUP62 nucleoporin 62kDa Mapped by PBA pathway
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 Mapped by CNV
HMBS hydroxymethylbilane synthase Mapped by significant region
PIK3C3 phosphoinositide-3-kinase, class 3 Mapped by significant region
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 Mapped by significant region
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Mapped by CNV
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 Mapped by significant region
LYPLA1 lysophospholipase I Mapped by PBA pathway
SLCO1B3 solute carrier organic anion transporter family, member 1B3 Mapped by LD-proxy
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 Mapped by CNV
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 Mapped by CNV
PRODH proline dehydrogenase (oxidase) 1 Mapped by CNV
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 Mapped by CNV
GSTP1 glutathione S-transferase pi 1 Mapped by significant region
BAAT bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) Mapped by significant region
LIPE lipase, hormone-sensitive Mapped by PBA pathway
GALT galactose-1-phosphate uridylyltransferase Mapped by LD-proxy
SQLE squalene epoxidase Mapped by CNV
ACACA acetyl-CoA carboxylase alpha Mapped by CNV
CHRM3 cholinergic receptor, muscarinic 3 Mapped by CNV; Mapped by PBA pathway
TM7SF2 transmembrane 7 superfamily member 2 Mapped by significant region
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide Mapped by CNV
NUPL2 nucleoporin like 2 Mapped by CNV; Mapped by significant region
AUH AU RNA binding protein/enoyl-CoA hydratase Mapped by significant region
CA3 carbonic anhydrase III, muscle specific Mapped by CNV
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mapped by PBA pathway
NT5M 5',3'-nucleotidase, mitochondrial Mapped by significant region
PLA2G10 phospholipase A2, group X Mapped by PBA pathway; Mapped by significant region
ACAT1 acetyl-CoA acetyltransferase 1 Mapped by CNV; Mapped by significant region
DSE dermatan sulfate epimerase Mapped by significant region
CA5A carbonic anhydrase VA, mitochondrial Mapped by significant region
GMPR2 guanosine monophosphate reductase 2 Mapped by significant region
HAAO 3-hydroxyanthranilate 3,4-dioxygenase Mapped by LD-proxy
ACAD8 acyl-CoA dehydrogenase family, member 8 Mapped by CNV; Mapped by significant region
MGLL monoglyceride lipase Mapped by PBA pathway
INS insulin Mapped by literature SNP
APOA4 apolipoprotein A-IV Mapped by significant region
SCARB1 scavenger receptor class B, member 1 Mapped by CNV
GLUL glutamate-ammonia ligase Mapped by significant region
CA13 carbonic anhydrase XIII Mapped by CNV
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) Mapped by significant region
GLYAT glycine-N-acyltransferase Mapped by LD-proxy; Mapped by significant region
STAB2 stabilin 2 Mapped by LD-proxy
PRKD1 protein kinase D1 Mapped by significant region
CA2 carbonic anhydrase II Mapped by CNV
CKMT1A creatine kinase, mitochondrial 1A Mapped by LD-proxy
ACER3 alkaline ceramidase 3 Mapped by significant region
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta Mapped by CNV
B3GNT1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 Mapped by significant region
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 Mapped by significant region
B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) Mapped by significant region
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway
PLD3 phospholipase D family, member 3 Mapped by PBA pathway
MED1 mediator complex subunit 1 Mapped by LD-proxy; Mapped by PBA pathway
PLD2 phospholipase D2 Mapped by PBA pathway
APOA1 apolipoprotein A-I Mapped by significant region
SUMF1 sulfatase modifying factor 1 Mapped by CNV
CA1 carbonic anhydrase I Mapped by CNV
CTGF connective tissue growth factor Mapped by significant region
DLAT dihydrolipoamide S-acetyltransferase Mapped by significant region
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Mapped by significant region
NPAS2 neuronal PAS domain protein 2 Mapped by CNV
ALDOB aldolase B, fructose-bisphosphate Mapped by significant region
ARSJ arylsulfatase family, member J Mapped by CNV
GRHL1 grainyhead-like 1 (Drosophila) Mapped by significant region
ALDOA aldolase A, fructose-bisphosphate Mapped by CNV
ACHE acetylcholinesterase Mapped by PBA pathway
B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mapped by CNV; Mapped by significant region
PLD6 phospholipase D family, member 6 Mapped by significant region
ACSM2B acyl-CoA synthetase medium-chain family member 2B Mapped by significant region
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 Mapped by significant region
PLA2G3 phospholipase A2, group III Mapped by PBA pathway
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal Mapped by CNV; Mapped by PBA pathway
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 Mapped by CNV
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 Mapped by LD-proxy; Mapped by literature SNP
UQCRC2 ubiquinol-cytochrome c reductase core protein II Mapped by CNV; Mapped by significant region
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Mapped by significant region
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 Mapped by significant region
PNLIPRP2 pancreatic lipase-related protein 2 Mapped by PBA pathway
TPTE2 transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 Mapped by significant region
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit Mapped by CNV
FABP6 fatty acid binding protein 6, ileal Mapped by significant region
UGCG UDP-glucose ceramide glucosyltransferase Mapped by significant region
NCOR2 nuclear receptor corepressor 2 Mapped by CNV
ACSM1 acyl-CoA synthetase medium-chain family member 1 Mapped by significant region
LPIN1 lipin 1 Mapped by significant region
GGT1 gamma-glutamyltransferase 1 Mapped by CNV
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Mapped by LD-proxy
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Mapped by significant region
PNLIP pancreatic lipase Mapped by PBA pathway
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) Mapped by PBA pathway
PLA2G2E phospholipase A2, group IIE Mapped by PBA pathway
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G Mapped by significant region
APOC3 apolipoprotein C-III Mapped by significant region
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) Mapped by CNV; Mapped by significant region
PLA2G2D phospholipase A2, group IID Mapped by PBA pathway
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Mapped by PBA pathway; Mapped by significant region
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 Mapped by CNV
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 Mapped by significant region
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Mapped by significant region
IYD iodotyrosine deiodinase Mapped by CNV
PNPLA3 patatin-like phospholipase domain containing 3 Mapped by PBA pathway
BCMO1 beta-carotene 15,15'-monooxygenase 1 Mapped by significant region
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) Mapped by PBA pathway
MTMR2 myotubularin related protein 2 Mapped by significant region
GNG10 guanine nucleotide binding protein (G protein), gamma 10 Mapped by significant region
WASL Wiskott-Aldrich syndrome-like Mapped by CNV
PEMT phosphatidylethanolamine N-methyltransferase Mapped by significant region
AMACR alpha-methylacyl-CoA racemase Mapped by significant region
NCOA6 nuclear receptor coactivator 6 Mapped by PBA pathway
SLC44A1 solute carrier family 44, member 1 Mapped by CNV; Mapped by significant region
ADAL adenosine deaminase-like Mapped by LD-proxy
TREH trehalase (brush-border membrane glycoprotein) Mapped by significant region
RRM2 ribonucleotide reductase M2 Mapped by significant region
PYGM phosphorylase, glycogen, muscle Mapped by significant region
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) Mapped by CNV; Mapped by significant region
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 Mapped by significant region
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 Mapped by significant region
ELOVL7 ELOVL fatty acid elongase 7 Mapped by CNV
INPPL1 inositol polyphosphate phosphatase-like 1 Mapped by significant region
APOC2 apolipoprotein C-II Mapped by PBA pathway
PLA2G1B phospholipase A2, group IB (pancreas) Mapped by PBA pathway
CHST6 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6 Mapped by significant region
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 Mapped by significant region
FECH ferrochelatase Mapped by significant region
NNMT nicotinamide N-methyltransferase Mapped by significant region
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) Mapped by PBA pathway; Mapped by significant region
SHMT1 serine hydroxymethyltransferase 1 (soluble) Mapped by significant region
MVD mevalonate (diphospho) decarboxylase Mapped by significant region
PLA2G16 phospholipase A2, group XVI Mapped by significant region
NCOR1 nuclear receptor corepressor 1 Mapped by significant region
MBOAT2 membrane bound O-acyltransferase domain containing 2 Mapped by significant region
CYCS cytochrome c, somatic Mapped by CNV; Mapped by significant region
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein Mapped by significant region
APOA5 apolipoprotein A-V Mapped by significant region
QPRT quinolinate phosphoribosyltransferase Mapped by CNV
STARD5 StAR-related lipid transfer (START) domain containing 5 Mapped by LD-proxy
MBOAT1 membrane bound O-acyltransferase domain containing 1 Mapped by LD-proxy; Mapped by literature SNP
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 Mapped by significant region

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Last update: Feb 26, 2014