ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0045892
Name	negative regulation of transcription, DNA-dependent
Type	Biological Process
No. of Genes in ADHDgene	64
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 64)

Literature-origin genes (count: 11)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
FOXP2	forkhead box P2	7q31	1(1/0/0)	IDA[18987363]
EREG	epiregulin	4q21.21	1(0/0/1)	IDA[14581411]
ATXN1	ataxin 1	6p23	1(0/0/1)	IDA[15016912]
PER1	period homolog 1 (Drosophila)	17p13.1	1(0/1/0)
ELK3	ELK3, ETS-domain protein (SRF accessory protein 2)	12q23	2(2/0/0)	IDA[12933792]
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)
ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein	2p25	1(0/1/0)	IDA[14627819]
HES1	hairy and enhancer of split 1, (Drosophila)	3q28-q29	1(1/0/0)	IDA[12535671]
PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F	22q11.22	1(0/0/1)
ZNF423	zinc finger protein 423	16q12	1(0/0/1)	IDA[10660046]
FOXP1	forkhead box P1	3p14.1	1(0/0/1)

Genes from other sources (count: 53)

Approved Symbol	Approved Name	Source	Evidence[PMID]
ZNF263	zinc finger protein 263	Mapped by LD-proxy
WWP1	WW domain containing E3 ubiquitin protein ligase 1	Mapped by CNV
KLF4	Kruppel-like factor 4 (gut)	Mapped by significant region	IDA[9422764]
THAP7	THAP domain containing 7	Mapped by CNV	IDA[17577209]
FOXE1	forkhead box E1 (thyroid transcription factor 2)	Mapped by significant region
ZBTB16	zinc finger and BTB domain containing 16	Mapped by significant region	IDA[12802276]; NAS[9294197]
PPARGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	Mapped by PBA pathway
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region	IDA[17350185]
HMGA1	high mobility group AT-hook 1	Mapped by PBA pathway	IMP[16901784]
ZNF24	zinc finger protein 24	Mapped by significant region	IDA[10585455]
CHMP1A	chromatin modifying protein 1A	Mapped by significant region	IDA[11559747]
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV
HINFP	histone H4 transcription factor	Mapped by significant region	IDA[17163457]
GATA6	GATA binding protein 6	Mapped by significant region	IDA[18177748]
BCLAF1	BCL2-associated transcription factor 1	Mapped by significant region	IDA[10330179]; TAS[10330179]
KCTD1	potassium channel tetramerisation domain containing 1	Mapped by significant region	IDA[19115315]
PTPRK	protein tyrosine phosphatase, receptor type, K	Mapped by CNV; Mapped by significant region	IDA[18276111]
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	Mapped by significant region	IDA[15163635]
KAT5	K(lysine) acetyltransferase 5	Mapped by significant region	IDA[17360565]
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	Mapped by significant region	IMP[8621488]
TNFSF4	tumor necrosis factor (ligand) superfamily, member 4	Mapped by significant region
LGR4	leucine-rich repeat containing G protein-coupled receptor 4	Mapped by LD-proxy
MPHOSPH8	M-phase phosphoprotein 8	Mapped by significant region
RSF1	remodeling and spacing factor 1	Mapped by significant region	IDA[11944984]
ATP8B1	ATPase, aminophospholipid transporter, class I, type 8B, member 1	Mapped by significant region	IMP[16628629]
CREBZF	CREB/ATF bZIP transcription factor	Mapped by significant region	IMP[15705566]
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	Mapped by significant region	IMP[12805222]
HOXA7	homeobox A7	Mapped by significant region	IDA[11435435]
LHX1	LIM homeobox 1	Mapped by CNV
NIPBL	Nipped-B homolog (Drosophila)	Mapped by significant region	IDA[18854353]
HSPA8	heat shock 70kDa protein 8	Mapped by significant region	IDA[10722728]
CBX3	chromobox homolog 3	Mapped by CNV; Mapped by significant region	IDA[9636147]; IMP[9636147]
RBPJ	recombination signal binding protein for immunoglobulin kappa J region	Mapped by CNV	IDA[10713164]
ERN2	endoplasmic reticulum to nucleus signaling 2	Mapped by significant region	IMP[11175748]
MEN1	multiple endocrine neoplasia I	Mapped by significant region	IDA[12226747]
CCDC85B	coiled-coil domain containing 85B	Mapped by significant region	IDA[17014843]
GREM1	gremlin 1	Mapped by CNV; Mapped by significant region
DAXX	death-domain associated protein	Mapped by LD-proxy; Mapped by PBA pathway	IDA[10698492]
FOXG1	forkhead box G1	Mapped by significant region	IDA[12657635]
MYB	v-myb myeloblastosis viral oncogene homolog (avian)	Mapped by significant region
WNT11	wingless-type MMTV integration site family, member 11	Mapped by significant region
EED	embryonic ectoderm development	Mapped by significant region	NAS[9584199]
KDM1A	lysine (K)-specific demethylase 1A	Mapped by LD-proxy	IDA[19497860]
SNW1	SNW domain containing 1	Mapped by PBA pathway	IDA[15878163]
SPI1	spleen focus forming virus (SFFV) proviral integration oncogene spi1	Mapped by LD-proxy
STRN3	striatin, calmodulin binding protein 3	Mapped by significant region	IDA[11570823]
HEY2	hairy/enhancer-of-split related with YRPW motif 2	Mapped by significant region	IDA[12535671]
BRMS1	breast cancer metastasis suppressor 1	Mapped by significant region
RASD1	RAS, dexamethasone-induced 1	Mapped by significant region
PDCD4	programmed cell death 4 (neoplastic transformation inhibitor)	Mapped by LD-proxy	IDA[16357133]
RREB1	ras responsive element binding protein 1	Mapped by CNV
RCOR2	REST corepressor 2	Mapped by significant region
TNP1	transition protein 1 (during histone to protamine replacement)	Mapped by significant region	IDA[12743712]