ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0048471
Name	perinuclear region of cytoplasm
Type	Cellular Component
No. of Genes in ADHDgene	87
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 87)

Literature-origin genes (count: 12)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
BDNF	brain-derived neurotrophic factor	11p14.1	14(8/6/0)
ATXN2	ataxin 2	12q23-q24.1	1(0/0/1)	IDA[17097639]
NOS1	nitric oxide synthase 1 (neuronal)	12q14-qter	1(1/0/0)	ISS[17027776]
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	18(13/5/0)
GSK3B	glycogen synthase kinase 3 beta	3q13.3	1(1/0/0)
AANAT	aralkylamine N-acetyltransferase	17q25	1(0/0/1)	IDA[11313340]
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	6q25.2-q27	1(1/0/0)	IDA[17097639]
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)
PPM1F	protein phosphatase, Mg2+/Mn2+ dependent, 1F	22q11.22	1(0/0/1)
MAGI2	membrane associated guanylate kinase, WW and PDZ domain containing 2	7q21	1(0/0/1)
PSMC3	proteasome (prosome, macropain) 26S subunit, ATPase, 3	11p11.2	1(0/0/1)
MOBP	myelin-associated oligodendrocyte basic protein	3p21.33	1(0/0/1)

Genes from other sources (count: 75)

Approved Symbol	Approved Name	Source	Evidence[PMID]
MAP7	microtubule-associated protein 7	Mapped by PBA pathway; Mapped by significant region
ALG2	asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)	Mapped by significant region	IDA[17196169]
GOLGA1	golgin A1	Mapped by significant region
TPPP	tubulin polymerization promoting protein	Mapped by PBA pathway	IDA[15590652]
GALNT1	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)	Mapped by significant region	IDA[12506059]
MS4A3	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	Mapped by significant region
PICALM	phosphatidylinositol binding clathrin assembly protein	Mapped by significant region
EPHA5	EPH receptor A5	Mapped by CNV; Mapped by significant region	IDA[10375373]
MALT1	mucosa associated lymphoid tissue lymphoma translocation gene 1	Mapped by significant region
MAP6	microtubule-associated protein 6	Mapped by significant region	IDA[17210638]
TRAPPC2L	trafficking protein particle complex 2-like	Mapped by significant region
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	Mapped by PBA pathway
UNC45A	unc-45 homolog A (C. elegans)	Mapped by LD-proxy
PLD1	phospholipase D1, phosphatidylcholine-specific	Mapped by PBA pathway
CYFIP2	cytoplasmic FMR1 interacting protein 2	Mapped by significant region	IDA[10449408]
NOX4	NADPH oxidase 4	Mapped by significant region
SPIRE1	spire homolog 1 (Drosophila)	Mapped by CNV
RAB14	RAB14, member RAS oncogene family	Mapped by PBA pathway; Mapped by significant region
PDE2A	phosphodiesterase 2A, cGMP-stimulated	Mapped by significant region	IDA[10375378]
STX7	syntaxin 7	Mapped by PBA pathway; Mapped by significant region
CABP2	calcium binding protein 2	Mapped by significant region
PRDX5	peroxiredoxin 5	Mapped by significant region	IDA[10095767]
RC3H2	ring finger and CCCH-type domains 2	Mapped by significant region
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Mapped by LD-proxy
ENPP3	ectonucleotide pyrophosphatase/phosphodiesterase 3	Mapped by significant region	IDA[10513816]
CLINT1	clathrin interactor 1	Mapped by significant region
OBSL1	obscurin-like 1	Mapped by significant region	TAS[17289344]
PLA2G5	phospholipase A2, group V	Mapped by PBA pathway
MAP1S	microtubule-associated protein 1S	Mapped by PBA pathway	IDA[12762840]
KAT5	K(lysine) acetyltransferase 5	Mapped by significant region
PTCH1	patched 1	Mapped by significant region	IDA[11278759]
SLC39A13	solute carrier family 39 (zinc transporter), member 13	Mapped by LD-proxy	ISS[18985159]
OPTN	optineurin	Mapped by PBA pathway
SYT4	synaptotagmin IV	Mapped by significant region
KLHL20	kelch-like 20 (Drosophila)	Mapped by significant region
SLC2A12	solute carrier family 2 (facilitated glucose transporter), member 12	Mapped by significant region
CEP250	centrosomal protein 250kDa	Mapped by PBA pathway
DGAT2	diacylglycerol O-acyltransferase 2	Mapped by significant region
NPC1	Niemann-Pick disease, type C1	Mapped by significant region	IDA[12554680]
PNPLA8	patatin-like phospholipase domain containing 8	Mapped by PBA pathway
CALN1	calneuron 1	Mapped by CNV
CTGF	connective tissue growth factor	Mapped by significant region
STK16	serine/threonine kinase 16	Mapped by significant region
DCTN3	dynactin 3 (p22)	Mapped by LD-proxy	IDA[9722614]
VPS33B	vacuolar protein sorting 33 homolog B (yeast)	Mapped by LD-proxy	IDA[19109425]
GSN	gelsolin	Mapped by PBA pathway; Mapped by significant region
EHD1	EH-domain containing 1	Mapped by significant region
SIPA1	signal-induced proliferation-associated 1	Mapped by significant region
GDPD5	glycerophosphodiester phosphodiesterase domain containing 5	Mapped by significant region
TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa	Mapped by CNV	IDA[15870280]
NRBP1	nuclear receptor binding protein 1	Mapped by PBA pathway
STX6	syntaxin 6	Mapped by significant region	IDA[10506127]
PLN	phospholamban	Mapped by significant region
AATK	apoptosis-associated tyrosine kinase	Mapped by LD-proxy
USP2	ubiquitin specific peptidase 2	Mapped by significant region
BSPRY	B-box and SPRY domain containing	Mapped by significant region
LPXN	leupaxin	Mapped by significant region
TLR4	toll-like receptor 4	Mapped by significant region	IDA[15027902]
DCUN1D3	DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)	Mapped by significant region	IDA[18823379]
CYFIP1	cytoplasmic FMR1 interacting protein 1	Mapped by significant region
TYR	tyrosinase (oculocutaneous albinism IA)	Mapped by significant region	IDA[11092760]
KRT18	keratin 18	Mapped by PBA pathway
SORT1	sortilin 1	Mapped by CNV	IDA[11331584]
RASD1	RAS, dexamethasone-induced 1	Mapped by significant region
HERC5	hect domain and RLD 5	Mapped by CNV
FAM168B	family with sequence similarity 168, member B	Mapped by CNV; Mapped by significant region
STX4	syntaxin 4	Mapped by CNV
ACHE	acetylcholinesterase	Mapped by PBA pathway	IDA[14766237]
GAK	cyclin G associated kinase	Mapped by LD-proxy
EHD3	EH-domain containing 3	Mapped by CNV
NF2	neurofibromin 2 (merlin)	Mapped by PBA pathway	IDA[17210637]
PLA2G16	phospholipase A2, group XVI	Mapped by significant region
TPD52L1	tumor protein D52-like 1	Mapped by significant region	IDA[12963375]
PRKAR2B	protein kinase, cAMP-dependent, regulatory, type II, beta	Mapped by CNV
CDK5RAP2	CDK5 regulatory subunit associated protein 2	Mapped by significant region	IDA[17959831]