ADHDgene Database
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Keyword:
Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005262
Name calcium channel activity
Type Molecular Function
No. of Genes in ADHDgene  40
Source Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)
Data Set Reference Gene Set Mapping Rule P-value FDR Result Link
Neale BM, 2008 MsigDB 3.0 c5.mf 5kb upstream and downstream of gene < 0.001 0.008 Link

Comments for this pathway (count: 3)
PMID Citation Comment
21130132 Mick E, McGough JJ, et al.Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder. Prog Neuro-Psychopharmacol Biol Psychiatry 2011, 35(2):466-472.
11772131 Jimenez-Jimenez FJ, Garcia-Ruiz PJ: Pharmacological options for the treatment of Tourette's disorder. Drugs 2001, 61(15):2207-2220. calcium channel antagonists is a potential usefulness drug f...... calcium channel antagonists is a potential usefulness drug for the patients suffering from the Tourette's disorder,which is associated with ADHD, More...
7976448 Sallee FR, Sethuraman G, Rock CM Effects of pimozide on cognition in children with Tourette syndrome: interaction with comorbid attention deficit hyperactivity disorder. Acta Psychiatr Scand 1994, 90(1):4-9. Pimozide,a L-type calcium channel blocker,has a significant ...... Pimozide,a L-type calcium channel blocker,has a significant impact on the patients with TS and ADHD More...

GO related genes in ADHDgene (count: 40)

Literature-origin genes (count: 3)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 1(1/0/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 3(1/2/0)

Genes from other sources Help (count: 37)

Approved Symbol Approved Name Source Evidence[PMID]
TRPC1 transient receptor potential cation channel, subfamily C, member 1 Mapped by PBA pathway TAS[8646775]
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 Mapped by PBA pathway
TRPM2 transient receptor potential cation channel, subfamily M, member 2 Mapped by PBA pathway
CACNB2 calcium channel, voltage-dependent, beta 2 subunit Mapped by PBA pathway NAS[9594024]
PDE2A phosphodiesterase 2A, cGMP-stimulated Mapped by significant region TAS[10375378]
CACNG5 calcium channel, voltage-dependent, gamma subunit 5 Mapped by PBA pathway
TRPM1 transient receptor potential cation channel, subfamily M, member 1 Mapped by CNV; Mapped by PBA pathway; Mapped by significant region TAS[9806836]
TRPV1 transient receptor potential cation channel, subfamily V, member 1 Mapped by PBA pathway
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit Mapped by PBA pathway
CUL5 cullin 5 Mapped by PBA pathway; Mapped by significant region TAS[9581826]
RYR2 ryanodine receptor 2 (cardiac) Mapped by CNV; Mapped by PBA pathway
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit Mapped by PBA pathway
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 Mapped by PBA pathway
TRPC5 transient receptor potential cation channel, subfamily C, member 5 Mapped by PBA pathway
CACNB3 calcium channel, voltage-dependent, beta 3 subunit Mapped by PBA pathway
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Mapped by PBA pathway; Mapped by significant region
TRPV2 transient receptor potential cation channel, subfamily V, member 2 Mapped by significant region
RYR3 ryanodine receptor 3 Mapped by CNV; Mapped by PBA pathway
TRPC4 transient receptor potential cation channel, subfamily C, member 4 Mapped by PBA pathway
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit Mapped by PBA pathway
PANX1 pannexin 1 Mapped by significant region IMP[16908669]
TRPV5 transient receptor potential cation channel, subfamily V, member 5 Mapped by PBA pathway
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 Mapped by PBA pathway
CACNB4 calcium channel, voltage-dependent, beta 4 subunit Mapped by PBA pathway
TRPV6 transient receptor potential cation channel, subfamily V, member 6 Mapped by PBA pathway IDA[15184369]
CACNB1 calcium channel, voltage-dependent, beta 1 subunit Mapped by PBA pathway
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit Mapped by PBA pathway
TRPC3 transient receptor potential cation channel, subfamily C, member 3 Mapped by PBA pathway TAS[9930701]
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A Mapped by significant region
ORAI1 ORAI calcium release-activated calcium modulator 1 Mapped by PBA pathway
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide) Mapped by PBA pathway; Mapped by significant region TAS[9169438]
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 Mapped by PBA pathway
RYR1 ryanodine receptor 1 (skeletal) Mapped by PBA pathway
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit Mapped by PBA pathway
CATSPER2 cation channel, sperm associated 2 Mapped by LD-proxy
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mapped by PBA pathway

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014