ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0005509
Name	calcium ion binding
Type	Molecular Function
No. of Genes in ADHDgene	124
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 124)

Literature-origin genes (count: 14)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	4q21.3-q22	1(0/1/0)	IDA[11850416]
GRM7	glutamate receptor, metabotropic 7	3p26-p25	1(1/0/0)	IDA[18599484]
CDH23	cadherin-related 23	10q22.1	1(0/1/0)
KCNIP4	Kv channel interacting protein 4	4p15.32	1(1/0/0)
NUCB1	nucleobindin 1	19q13.33	1(0/0/1)
SYT2	synaptotagmin II	1q32.1	1(1/0/0)
MCTP1	multiple C2 domains, transmembrane 1	5q15	1(0/1/0)	IDA[15528213]
TLL2	tolloid-like 2	10q23-q24	1(0/0/1)
PLCL1	phospholipase C-like 1	2q33	1(0/0/1)
SLIT1	slit homolog 1 (Drosophila)	10q23.3-q24	1(0/0/1)	NAS[9813312]
SYP	synaptophysin	Xp11.23-p11.22	3(3/0/0)
CDH13	cadherin 13, H-cadherin (heart)	16q23.3	3(1/1/1)
MMP24	matrix metallopeptidase 24 (membrane-inserted)	20q11.2	1(0/0/1)
SYT1	synaptotagmin I	12cen-q21	4(2/2/0)

Genes from other sources (count: 110)

Approved Symbol	Approved Name	Source	Evidence[PMID]
PLCB2	phospholipase C, beta 2	Mapped by PBA pathway
REPS2	RALBP1 associated Eps domain containing 2	Mapped by CNV
ADAM8	ADAM metallopeptidase domain 8	Mapped by CNV; Mapped by LD-proxy
EFHA1	EF-hand domain family, member A1	Mapped by significant region
PLCB3	phospholipase C, beta 3 (phosphatidylinositol-specific)	Mapped by significant region
EFCAB5	EF-hand calcium binding domain 5	Mapped by LD-proxy
EFEMP2	EGF containing fibulin-like extracellular matrix protein 2	Mapped by significant region
MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	Mapped by significant region
EEF2K	eukaryotic elongation factor-2 kinase	Mapped by CNV; Mapped by significant region
NECAB2	N-terminal EF-hand calcium binding protein 2	Mapped by CNV; Mapped by significant region
CABP2	calcium binding protein 2	Mapped by significant region
DSC2	desmocollin 2	Mapped by significant region
CABP4	calcium binding protein 4	Mapped by significant region	NAS[16960802]; TAS[15452577]
CRB2	crumbs homolog 2 (Drosophila)	Mapped by significant region
PLA2G10	phospholipase A2, group X	Mapped by PBA pathway; Mapped by significant region
DSC3	desmocollin 3	Mapped by significant region
CABYR	calcium binding tyrosine-(Y)-phosphorylation regulated	Mapped by significant region	IDA[11820818]
MMP27	matrix metallopeptidase 27	Mapped by significant region
RYR1	ryanodine receptor 1 (skeletal)	Mapped by PBA pathway
MASP2	mannan-binding lectin serine peptidase 2	Mapped by literature SNP
MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	Mapped by significant region
DSC1	desmocollin 1	Mapped by significant region
PKD1L2	polycystic kidney disease 1-like 2	Mapped by significant region
EHD3	EH-domain containing 3	Mapped by CNV
MYLPF	myosin light chain, phosphorylatable, fast skeletal muscle	Mapped by CNV
MAN1A1	mannosidase, alpha, class 1A, member 1	Mapped by significant region
CALN1	calneuron 1	Mapped by CNV
PLA2G5	phospholipase A2, group V	Mapped by PBA pathway
SUSD1	sushi domain containing 1	Mapped by significant region
PPP3R2	protein phosphatase 3, regulatory subunit B, beta	Mapped by significant region
KCNIP1	Kv channel interacting protein 1	Mapped by LD-proxy; Mapped by literature SNP
CDHR5	cadherin-related family member 5	Mapped by LD-proxy
RYR2	ryanodine receptor 2 (cardiac)	Mapped by CNV; Mapped by PBA pathway
CDHR1	cadherin-related family member 1	Mapped by CNV
FAT3	FAT tumor suppressor homolog 3 (Drosophila)	Mapped by significant region
EHD1	EH-domain containing 1	Mapped by significant region
EYS	eyes shut homolog (Drosophila)	Mapped by significant region
CDH6	cadherin 6, type 2, K-cadherin (fetal kidney)	Mapped by significant region
F10	coagulation factor X	Mapped by CNV
LPCAT4	lysophosphatidylcholine acyltransferase 4	Mapped by CNV
RYR3	ryanodine receptor 3	Mapped by CNV; Mapped by PBA pathway
LTBP3	latent transforming growth factor beta binding protein 3	Mapped by significant region
NDUFAB1	NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa	Mapped by significant region	NAS[10234612]
LTBP1	latent transforming growth factor beta binding protein 1	Mapped by CNV
CDH4	cadherin 4, type 1, R-cadherin (retinal)	Mapped by CNV
TBC1D9B	TBC1 domain family, member 9B (with GRAM domain)	Mapped by CNV
PLA2G4B	phospholipase A2, group IVB (cytosolic)	Mapped by PBA pathway	NAS[10085124]
VWCE	von Willebrand factor C and EGF domains	Mapped by significant region
LPCAT1	lysophosphatidylcholine acyltransferase 1	Mapped by LD-proxy
RASGRP2	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	Mapped by significant region	NAS[10918068]; TAS[9789079]
SVEP1	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	Mapped by significant region
CDH19	cadherin 19, type 2	Mapped by CNV; Mapped by LD-proxy
PLA2G3	phospholipase A2, group III	Mapped by PBA pathway
PNLIPRP2	pancreatic lipase-related protein 2	Mapped by PBA pathway	IDA[18702514]
PCDH7	protocadherin 7	Mapped by CNV
MEGF9	multiple EGF-like-domains 9	Mapped by significant region
CDH2	cadherin 2, type 1, N-cadherin (neuronal)	Mapped by significant region
CUBN	cubilin (intrinsic factor-cobalamin receptor)	Mapped by CNV
CBL	Cas-Br-M (murine) ecotropic retroviral transforming sequence	Mapped by significant region
CELSR2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	Mapped by CNV
PLA2G2E	phospholipase A2, group IIE	Mapped by PBA pathway
EDEM2	ER degradation enhancer, mannosidase alpha-like 2	Mapped by LD-proxy; Mapped by literature SNP
CANX	calnexin	Mapped by CNV
PPEF2	protein phosphatase, EF-hand calcium binding domain 2	Mapped by CNV
DCHS1	dachsous 1 (Drosophila)	Mapped by CNV
HPCAL1	hippocalcin-like 1	Mapped by significant region
PNLIPRP1	pancreatic lipase-related protein 1	Mapped by PBA pathway
TLL1	tolloid-like 1	Mapped by LD-proxy; Mapped by literature SNP
EDEM3	ER degradation enhancer, mannosidase alpha-like 3	Mapped by significant region
MMP1	matrix metallopeptidase 1 (interstitial collagenase)	Mapped by significant region
PLA2G2D	phospholipase A2, group IID	Mapped by PBA pathway
ACTN3	actinin, alpha 3	Mapped by significant region
ASPN	asporin	Mapped by significant region	IDA[19589127]
CD248	CD248 molecule, endosialin	Mapped by significant region
DUOX2	dual oxidase 2	Mapped by CNV	IDA[15972824]
SYT7	synaptotagmin VII	Mapped by significant region
PLCH1	phospholipase C, eta 1	Mapped by PBA pathway
F7	coagulation factor VII (serum prothrombin conversion accelerator)	Mapped by CNV
SPOCK3	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	Mapped by CNV; Mapped by LD-proxy; Mapped by literature SNP
MMP10	matrix metallopeptidase 10 (stromelysin 2)	Mapped by significant region
UMOD	uromodulin	Mapped by significant region
DUOX1	dual oxidase 1	Mapped by CNV
CDH15	cadherin 15, type 1, M-cadherin (myotubule)	Mapped by CNV; Mapped by significant region
SYT4	synaptotagmin IV	Mapped by significant region
PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)	Mapped by PBA pathway
HMCN1	hemicentin 1	Mapped by significant region
DTNA	dystrobrevin, alpha	Mapped by significant region
CCBE1	collagen and calcium binding EGF domains 1	Mapped by significant region
MMP11	matrix metallopeptidase 11 (stromelysin 3)	Mapped by CNV
SYNRG	synergin, gamma	Mapped by CNV
DSG4	desmoglein 4	Mapped by significant region
CDH12	cadherin 12, type 2 (N-cadherin 2)	Mapped by CNV
DSG3	desmoglein 3	Mapped by significant region
MMP12	matrix metallopeptidase 12 (macrophage elastase)	Mapped by significant region
MMP13	matrix metallopeptidase 13 (collagenase 3)	Mapped by significant region
GSN	gelsolin	Mapped by PBA pathway; Mapped by significant region	TAS[1321812]
CAPSL	calcyphosine-like	Mapped by significant region
STIM2	stromal interaction molecule 2	Mapped by CNV	IDA[18166150]
DSG2	desmoglein 2	Mapped by significant region
HSPA5	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Mapped by significant region	TAS[16130169]
PLA2G1B	phospholipase A2, group IB (pancreas)	Mapped by PBA pathway	IDA[7060561]
PLCD1	phospholipase C, delta 1	Mapped by PBA pathway
CAPN1	calpain 1, (mu/I) large subunit	Mapped by significant region
CLSTN2	calsyntenin 2	Mapped by CNV
MMP16	matrix metallopeptidase 16 (membrane-inserted)	Mapped by CNV
PLCD4	phospholipase C, delta 4	Mapped by significant region
PLCE1	phospholipase C, epsilon 1	Mapped by PBA pathway
DSG1	desmoglein 1	Mapped by significant region	NAS[1770008]
MMP20	matrix metallopeptidase 20	Mapped by significant region
VIL1	villin 1	Mapped by significant region	IDA[11500485]