ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0000226
Name	microtubule cytoskeleton organization
Type	Biological Process
No. of Genes in ADHDgene	39
Source	Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)

Data Set Reference	Gene Set	Mapping Rule	P-value	FDR	Result Link
Lesch KP, 2008	MsigDB 3.0 c5.bp	500kb upstream and downstream of gene	< 0.001	0.032333333	Link

Comments for this pathway (count: 1)

PMID	Citation	Comment
21438138	Ehlis A-C, Bauernschmitt K, et al.Influence of a Genetic Variant of the Neuronal Growth Associated Protein Stathmin 1 on Cognitive and Affective Control Processes: An Event-Related Potential Study. American Journal of Medical Genetics 2011, 156B(3):291-302.	Stathmin 1 (STMN1) is a neuronal growth associated protein (...... Stathmin 1 (STMN1) is a neuronal growth associated protein (NGAP) that is involved in microtubule dynamics and plays an important role in neurite outgrowth and synaptic plasticity.An influence of STMN1 should be considered in studies aiming at the etiopathogenesis of a broad range of neuropsychiatric disorders with dysfunctional networking, including neurodegenerative disorders as well as schizophrenia, autism spectrum disorders, anxiety disorders, depression, and ADHD More...

GO related genes in ADHDgene (count: 39)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
CLASP2	cytoplasmic linker associated protein 2	3p24.3	1(0/0/1)

Genes from other sources (count: 38)

Approved Symbol	Approved Name	Source	Evidence[PMID]
KIF23	kinesin family member 23	Mapped by PBA pathway
TUBG1	tubulin, gamma 1	Mapped by PBA pathway	TAS[1904010]
KIF11	kinesin family member 11	Mapped by PBA pathway
CENPJ	centromere protein J	Mapped by PBA pathway
PPP4C	protein phosphatase 4, catalytic subunit	Mapped by CNV
MAPRE1	microtubule-associated protein, RP/EB family, member 1	Mapped by PBA pathway
RAN	RAN, member RAS oncogene family	Mapped by PBA pathway
TUBGCP2	tubulin, gamma complex associated protein 2	Mapped by CNV; Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
HOOK3	hook homolog 3 (Drosophila)	Mapped by PBA pathway
CDK5RAP2	CDK5 regulatory subunit associated protein 2	Mapped by significant region	IDA[17959831]
MAP1S	microtubule-associated protein 1S	Mapped by PBA pathway
SMC1A	structural maintenance of chromosomes 1A	Mapped by PBA pathway
APC	adenomatous polyposis coli	Mapped by LD-proxy; Mapped by PBA pathway
MAP7	microtubule-associated protein 7	Mapped by PBA pathway; Mapped by significant region	TAS[8408219]
TUBGCP6	tubulin, gamma complex associated protein 6	Mapped by PBA pathway
KIF2C	kinesin family member 2C	Mapped by PBA pathway
CKAP5	cytoskeleton associated protein 5	Mapped by PBA pathway
PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	Mapped by PBA pathway	ISS[10729324]
MARK4	MAP/microtubule affinity-regulating kinase 4	Mapped by PBA pathway	IMP[14594945]
MAPT	microtubule-associated protein tau	Mapped by LD-proxy; Mapped by PBA pathway	IDA[1057175]
SMC3	structural maintenance of chromosomes 3	Mapped by PBA pathway
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	Mapped by PBA pathway
RCC1	regulator of chromosome condensation 1	Mapped by PBA pathway
TUBGCP5	tubulin, gamma complex associated protein 5	Mapped by PBA pathway; Mapped by significant region
TTK	TTK protein kinase	Mapped by PBA pathway
RNF19A	ring finger protein 19A	Mapped by PBA pathway	TAS[11237715]
CCDC88A	coiled-coil domain containing 88A	Mapped by PBA pathway
STMN1	stathmin 1	Mapped by PBA pathway
SS18	synovial sarcoma translocation, chromosome 18	Mapped by significant region
NUSAP1	nucleolar and spindle associated protein 1	Mapped by PBA pathway
PRC1	protein regulator of cytokinesis 1	Mapped by PBA pathway
MID1	midline 1 (Opitz/BBB syndrome)	Mapped by PBA pathway	TAS[10077590]
TPPP	tubulin polymerization promoting protein	Mapped by PBA pathway
CLASP1	cytoplasmic linker associated protein 1	Mapped by PBA pathway	IGI[15631994]
CCDC88B	coiled-coil domain containing 88B	Mapped by significant region
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	Mapped by PBA pathway
UXT	ubiquitously-expressed transcript	Mapped by PBA pathway	IMP[16221885]
KATNB1	katanin p80 (WD repeat containing) subunit B 1	Mapped by PBA pathway