ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0046982
Name	protein heterodimerization activity
Type	Molecular Function
No. of Genes in ADHDgene	68
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 68)

Literature-origin genes (count: 16)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
STX1A	syntaxin 1A (brain)	7q11.2	3(2/1/0)
H2AFY	H2A histone family, member Y	5q31.1	1(0/1/0)
UGT1A9	UDP glucuronosyltransferase 1 family, polypeptide A9	2q37	1(0/0/1)
FOXP2	forkhead box P2	7q31	1(1/0/0)
BCL11A	B-cell CLL/lymphoma 11A (zinc finger protein)	2p16.1	1(0/0/1)	IPI[19616629]
ADRB1	adrenergic, beta-1-, receptor	10q24-q26	2(0/2/0)	IPI[12529373]
ADRA1B	adrenergic, alpha-1B-, receptor	5q33.3	2(1/1/0)
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IDA[8702615]
NR4A2	nuclear receptor subfamily 4, group A, member 2	2q22-q23	2(0/2/0)
ADRA2C	adrenergic, alpha-2C-, receptor	4p16.3	7(2/4/1)	IPI[16605244]
ITGA1	integrin, alpha 1	5q11.1	1(0/1/0)
SUPT3H	suppressor of Ty 3 homolog (S. cerevisiae)	6p21.1-p12.3	1(0/0/1)
ADRA1A	adrenergic, alpha-1A-, receptor	8p21.2	3(2/1/0)
ADRA2A	adrenergic, alpha-2A-, receptor	10q24-q26	12(4/8/0)	IPI[16605244]
FOXP1	forkhead box P1	3p14.1	1(0/0/1)
TFEB	transcription factor EB	6p21	1(0/0/1)

Genes from other sources (count: 52)

Approved Symbol	Approved Name	Source	Evidence[PMID]
TTR	transthyretin	Mapped by significant region
IKZF1	IKAROS family zinc finger 1 (Ikaros)	Mapped by LD-proxy
TAF6L	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa	Mapped by significant region
ROBO3	roundabout, axon guidance receptor, homolog 3 (Drosophila)	Mapped by significant region
SMC3	structural maintenance of chromosomes 3	Mapped by PBA pathway	IPI[11590136]
CENPW	centromere protein W	Mapped by significant region
PAFAH1B2	platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)	Mapped by significant region
ALG2	asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)	Mapped by significant region	IPI[11278427]
H2AFX	H2A histone family, member X	Mapped by significant region
TAF4B	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa	Mapped by significant region
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	Mapped by CNV	IDA[10381623]
SYT10	synaptotagmin X	Mapped by CNV
UGT1A8	UDP glucuronosyltransferase 1 family, polypeptide A8	Mapped by LD-proxy; Mapped by literature SNP
INHA	inhibin, alpha	Mapped by significant region
BARD1	BRCA1 associated RING domain 1	Mapped by significant region	IPI[15265711]
ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Mapped by LD-proxy	IDA[10572067]; IPI[7556068]; NAS[15504738]
KATNB1	katanin p80 (WD repeat containing) subunit B 1	Mapped by PBA pathway	IPI[10751153]
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	Mapped by significant region
NEUROD2	neurogenic differentiation 2	Mapped by LD-proxy
BAD	BCL2-associated agonist of cell death	Mapped by significant region
PANX1	pannexin 1	Mapped by significant region
CABYR	calcium binding tyrosine-(Y)-phosphorylation regulated	Mapped by significant region
HNF1B	HNF1 homeobox B	Mapped by CNV
UGT1A7	UDP glucuronosyltransferase 1 family, polypeptide A7	Mapped by LD-proxy; Mapped by literature SNP
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	Mapped by significant region	IPI[1674604]
NPAS4	neuronal PAS domain protein 4	Mapped by significant region
DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	Mapped by significant region
UGT1A6	UDP glucuronosyltransferase 1 family, polypeptide A6	Mapped by LD-proxy
FZD4	frizzled family receptor 4	Mapped by significant region	IPI[14688793]
ABCG4	ATP-binding cassette, sub-family G (WHITE), member 4	Mapped by significant region	IPI[16870176]
VEGFB	vascular endothelial growth factor B	Mapped by significant region
CYBA	cytochrome b-245, alpha polypeptide	Mapped by significant region	IPI[12042318]
JAM3	junctional adhesion molecule 3	Mapped by significant region
UGT1A4	UDP glucuronosyltransferase 1 family, polypeptide A4	Mapped by LD-proxy
TAF13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa	Mapped by CNV
BDKRB2	bradykinin receptor B2	Mapped by PBA pathway	IPI[10993080]
SMC2	structural maintenance of chromosomes 2	Mapped by significant region	IPI[9789013]
SDCBP2	syndecan binding protein (syntenin) 2	Mapped by LD-proxy; Mapped by literature SNP	IPI[11152476]
CLCF1	cardiotrophin-like cytokine factor 1	Mapped by significant region	IDA[10966616]
UGT1A10	UDP glucuronosyltransferase 1 family, polypeptide A10	Mapped by LD-proxy; Mapped by literature SNP
UGT1A3	UDP glucuronosyltransferase 1 family, polypeptide A3	Mapped by LD-proxy
POLA2	polymerase (DNA directed), alpha 2 (70kD subunit)	Mapped by significant region
TYR	tyrosinase (oculocutaneous albinism IA)	Mapped by significant region
ADORA2A	adenosine A2a receptor	Mapped by CNV
CD3E	CD3e molecule, epsilon (CD3-TCR complex)	Mapped by significant region	IPI[9485181]
CD3G	CD3g molecule, gamma (CD3-TCR complex)	Mapped by significant region	IPI[9485181]
KCNIP1	Kv channel interacting protein 1	Mapped by LD-proxy; Mapped by literature SNP
SMC1A	structural maintenance of chromosomes 1A	Mapped by PBA pathway	IPI[11590136]
UGT1A1	UDP glucuronosyltransferase 1 family, polypeptide A1	Mapped by LD-proxy
CD3D	CD3d molecule, delta (CD3-TCR complex)	Mapped by significant region	IPI[9485181]
TPD52L1	tumor protein D52-like 1	Mapped by significant region	IDA[9484778]
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	Mapped by significant region	IDA[19509286]