ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0001666
Name	response to hypoxia
Type	Biological Process
No. of Genes in ADHDgene	34
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 34)

Literature-origin genes (count: 10)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
NR4A2	nuclear receptor subfamily 4, group A, member 2	2q22-q23	2(0/2/0)
VEGFA	vascular endothelial growth factor A	6p12	1(0/1/0)	IDA[16490744]
CHRNA4	cholinergic receptor, nicotinic, alpha 4	20	7(4/3/0)	IDA[12189247]
NOS1	nitric oxide synthase 1 (neuronal)	12q14-qter	1(1/0/0)	IEP[16276418]
SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	17q11.2	25(13/12/0)
TH	tyrosine hydroxylase	11p15.5	7(2/5/0)	IDA[17520326]
BDNF	brain-derived neurotrophic factor	11p14.1	14(8/6/0)
NPPC	natriuretic peptide C	2q24-qter	1(0/1/0)
CHRNA7	cholinergic receptor, nicotinic, alpha 7	15q13.3	2(0/1/1)	IDA[12189247]
DRD2	dopamine receptor D2	11q22-q23	10(3/7/0)

Genes from other sources (count: 24)

Approved Symbol	Approved Name	Source	Evidence[PMID]
ADAM17	ADAM metallopeptidase domain 17	Mapped by significant region	IDA[18276953]
PAK1	p21 protein (Cdc42/Rac)-activated kinase 1	Mapped by significant region
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	Mapped by significant region	NAS[8557660]
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	Mapped by significant region
SOD3	superoxide dismutase 3, extracellular	Mapped by CNV
ITPR1	inositol 1,4,5-trisphosphate receptor, type 1	Mapped by CNV	IDA[19120137]
UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	Mapped by CNV; Mapped by significant region
ALDH3A1	aldehyde dehydrogenase 3 family, member A1	Mapped by significant region
IL18	interleukin 18 (interferon-gamma-inducing factor)	Mapped by significant region
RYR2	ryanodine receptor 2 (cardiac)	Mapped by CNV; Mapped by PBA pathway
ITPR2	inositol 1,4,5-trisphosphate receptor, type 2	Mapped by LD-proxy; Mapped by literature SNP	IDA[19120137]
UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	Mapped by CNV; Mapped by significant region
BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	Mapped by CNV
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	Mapped by significant region
P2RX3	purinergic receptor P2X, ligand-gated ion channel, 3	Mapped by significant region
SLC2A8	solute carrier family 2 (facilitated glucose transporter), member 8	Mapped by significant region
ATM	ataxia telangiectasia mutated	Mapped by CNV; Mapped by significant region
EDNRA	endothelin receptor type A	Mapped by PBA pathway
ALKBH5	alkB, alkylation repair homolog 5 (E. coli)	Mapped by significant region
CRYAB	crystallin, alpha B	Mapped by significant region
NOX4	NADPH oxidase 4	Mapped by significant region
EGLN3	egl nine homolog 3 (C. elegans)	Mapped by LD-proxy; Mapped by literature SNP
SCFD1	sec1 family domain containing 1	Mapped by significant region
RYR1	ryanodine receptor 1 (skeletal)	Mapped by PBA pathway	IDA[19120137]