ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

GO Report

Basic Info

ID	GO:0043565
Name	sequence-specific DNA binding
Type	Molecular Function
No. of Genes in ADHDgene	72
Source	Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 72)

Literature-origin genes (count: 9)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)	Evidence[PMID]
FOXP2	forkhead box P2	7q31	1(1/0/0)	IDA[18987363]
DMRT2	doublesex and mab-3 related transcription factor 2	9p24.3	1(0/0/1)
NR4A2	nuclear receptor subfamily 4, group A, member 2	2q22-q23	2(0/2/0)
CREB5	cAMP responsive element binding protein 5	7p15	1(0/0/1)
MEIS2	Meis homeobox 2	15q14	1(0/0/1)	IDA[17178831]
NR3C2	nuclear receptor subfamily 3, group C, member 2	4q31	1(0/1/0)
HES1	hairy and enhancer of split 1, (Drosophila)	3q28-q29	1(1/0/0)
HOXB1	homeobox B1	17q21.32	1(0/0/1)
FOXP1	forkhead box P1	3p14.1	1(0/0/1)

Genes from other sources (count: 63)

Approved Symbol	Approved Name	Source	Evidence[PMID]
IKZF1	IKAROS family zinc finger 1 (Ikaros)	Mapped by LD-proxy
HOXA3	homeobox A3	Mapped by significant region
FOXE1	forkhead box E1 (thyroid transcription factor 2)	Mapped by significant region
FOXF1	forkhead box F1	Mapped by significant region	ISS[7957066]
PGR	progesterone receptor	Mapped by significant region
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	Mapped by significant region
CENPB	centromere protein B, 80kDa	Mapped by CNV	TAS[11682612]
PRDM1	PR domain containing 1, with ZNF domain	Mapped by CNV
TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	Mapped by CNV	IDA[8321221]
HOXA2	homeobox A2	Mapped by significant region
ZNF24	zinc finger protein 24	Mapped by significant region
NR4A3	nuclear receptor subfamily 4, group A, member 3	Mapped by significant region
TSHZ2	teashirt zinc finger homeobox 2	Mapped by LD-proxy; Mapped by literature SNP
HOXA5	homeobox A5	Mapped by significant region
POLE3	polymerase (DNA directed), epsilon 3 (p17 subunit)	Mapped by significant region
ESRRA	estrogen-related receptor alpha	Mapped by significant region
PKNOX2	PBX/knotted 1 homeobox 2	Mapped by significant region
LHX6	LIM homeobox 6	Mapped by significant region
FOXD4	forkhead box D4	Mapped by CNV	ISS[7957066]
FEV	FEV (ETS oncogene family)	Mapped by significant region
HOXA1	homeobox A1	Mapped by significant region
BATF2	basic leucine zipper transcription factor, ATF-like 2	Mapped by significant region
PBX3	pre-B-cell leukemia homeobox 3	Mapped by significant region
FOXR1	forkhead box R1	Mapped by significant region
TBX1	T-box 1	Mapped by CNV	IDA[11111039]
HOXA4	homeobox A4	Mapped by significant region
HNF1B	HNF1 homeobox B	Mapped by CNV
BSX	brain-specific homeobox	Mapped by significant region
FOXL1	forkhead box L1	Mapped by significant region	IDA[7957066]
CREBZF	CREB/ATF bZIP transcription factor	Mapped by significant region
NFE2L3	nuclear factor (erythroid-derived 2)-like 3	Mapped by CNV; Mapped by significant region
MEN1	multiple endocrine neoplasia I	Mapped by significant region
FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	Mapped by significant region	IDA[16081467]
DRAP1	DR1-associated protein 1 (negative cofactor 2 alpha)	Mapped by significant region
HOXA7	homeobox A7	Mapped by significant region	IDA[11435435]
LHX1	LIM homeobox 1	Mapped by CNV
HOXA10	homeobox A10	Mapped by significant region
RAX	retina and anterior neural fold homeobox	Mapped by LD-proxy; Mapped by significant region
HOXA6	homeobox A6	Mapped by significant region
MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	Mapped by significant region
FOXG1	forkhead box G1	Mapped by significant region
SREBF1	sterol regulatory element binding transcription factor 1	Mapped by significant region
NR6A1	nuclear receptor subfamily 6, group A, member 1	Mapped by significant region
ATF6	activating transcription factor 6	Mapped by CNV
ONECUT2	one cut homeobox 2	Mapped by significant region
HOXA11	homeobox A11	Mapped by significant region
VENTX	VENT homeobox	Mapped by CNV
MTA2	metastasis associated 1 family, member 2	Mapped by significant region
SOX30	SRY (sex determining region Y)-box 30	Mapped by significant region	IDA[10359848]
RORA	RAR-related orphan receptor A	Mapped by LD-proxy; Mapped by literature SNP
GSC2	goosecoid homeobox 2	Mapped by CNV
LHX2	LIM homeobox 2	Mapped by significant region
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mapped by significant region
IRX3	iroquois homeobox 3	Mapped by CNV
LMX1B	LIM homeobox transcription factor 1, beta	Mapped by significant region
HEY2	hairy/enhancer-of-split related with YRPW motif 2	Mapped by significant region	IDA[11486045]
HOXA9	homeobox A9	Mapped by significant region
HOXA13	homeobox A13	Mapped by significant region
MTA3	metastasis associated 1 family, member 3	Mapped by LD-proxy; Mapped by literature SNP
NCOR1	nuclear receptor corepressor 1	Mapped by significant region
POU2F3	POU class 2 homeobox 3	Mapped by significant region	IDA[9242494]
NR5A1	nuclear receptor subfamily 5, group A, member 1	Mapped by significant region
EVX1	even-skipped homeobox 1	Mapped by significant region