ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0007268
Name synaptic transmission
Type Biological Process
No. of Genes in ADHDgene  96
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 96)

Literature-origin genes (count: 42)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E 6q14-q15 2(2/0/0) TAS[1608964]
COMT catechol-O-methyltransferase 22q11.21 25(5/20/0)
SYT2 synaptotagmin II 1q32.1 1(1/0/0)
HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) 10q21-q24 1(0/1/0) TAS[8226867]
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F 3p12 1(0/1/0) TAS[8380639]
SLC5A7 solute carrier family 5 (choline transporter), member 7 2q12 1(1/0/0)
CHRNA3 cholinergic receptor, nicotinic, alpha 3 15q24 1(0/1/0)
GRIK1 glutamate receptor, ionotropic, kainate 1 21q22 1(0/0/1)
MTNR1B melatonin receptor 1B 11q21-q22 1(0/0/1) TAS[7568007]
HTR6 5-hydroxytryptamine (serotonin) receptor 6 1p36-p35 2(0/2/0) TAS[8522988]
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0) TAS[9076744]
SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 3p25-p24 1(0/1/0)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0)
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D 1p36.3-p34.3 2(1/1/0) TAS[1565658]
GRM5 glutamate receptor, metabotropic 5 11q14.3 2(1/0/1)
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 5p13 2(1/1/0) TAS[7521911]
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 17pter-p12 2(0/2/0)
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B 6q13 13(5/8/0)
GRIK4 glutamate receptor, ionotropic, kainate 4 11q 1(0/1/0)
STX1A syntaxin 1A (brain) 7q11.2 3(2/1/0)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 20 7(4/3/0) NAS[7550350]
SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 16q12.2 16(10/5/1) TAS[2008212]
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 5p15.3 68(42/25/1)
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B 11q23.1 3(1/2/0) TAS[9950429]
CHRNA7 cholinergic receptor, nicotinic, alpha 7 15q13.3 2(0/1/1)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 3(1/2/0)
SLC18A2 solute carrier family 18 (vesicular monoamine), member 2 10q25 2(0/2/0)
CPLX1 complexin 1 4p16.3 1(1/0/0)
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A 11q23.1-q23.2 1(0/1/0) TAS[7565620]
GABRG1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 4p12 1(0/0/1)
KCNC1 potassium voltage-gated channel, Shaw-related subfamily, member 1 11p15 1(0/1/0)
DRD5 dopamine receptor D5 4p16.1 22(14/6/2) NAS[7727453]
SNAP25 synaptosomal-associated protein, 25kDa 20p12-p11.2 18(13/5/0) NAS[8760387]
MAOA monoamine oxidase A Xp11.4-p11.3 20(13/7/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C Xq24 5(2/3/0) TAS[9241279]
GRM7 glutamate receptor, metabotropic 7 3p26-p25 1(1/0/0) IDA[9473604]
HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1 5p12 1(0/1/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 9q34 20(11/9/0) TAS[2880016]
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 12p12 1(1/0/0)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13q14-q21 12(6/6/0) TAS[9109547]
SYT1 synaptotagmin I 12cen-q21 4(2/2/0)

Genes from other sources Help (count: 54)

Approved Symbol Approved Name Source Evidence[PMID]
KCNK4 potassium channel, subfamily K, member 4 Mapped by significant region
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit Mapped by PBA pathway
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 Mapped by PBA pathway
PLCB2 phospholipase C, beta 2 Mapped by PBA pathway
KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5 Mapped by significant region
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) Mapped by significant region
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit Mapped by PBA pathway
KCNN2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 Mapped by LD-proxy
STX1B syntaxin 1B Mapped by CNV
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 Mapped by PBA pathway
KCNK7 potassium channel, subfamily K, member 7 Mapped by significant region
CHRNB4 cholinergic receptor, nicotinic, beta 4 Mapped by LD-proxy
UNC13C unc-13 homolog C (C. elegans) Mapped by CNV
CAMK2D calcium/calmodulin-dependent protein kinase II delta Mapped by CNV
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 Mapped by significant region
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit Mapped by PBA pathway; Mapped by significant region
CHRNA5 cholinergic receptor, nicotinic, alpha 5 Mapped by LD-proxy
ADCY4 adenylate cyclase 4 Mapped by significant region
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 Mapped by CNV; Mapped by significant region
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 Mapped by CNV; Mapped by significant region
GNG3 guanine nucleotide binding protein (G protein), gamma 3 Mapped by significant region
PANX1 pannexin 1 Mapped by significant region
NOVA1 neuro-oncological ventral antigen 1 Mapped by significant region TAS[8558240]
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit Mapped by PBA pathway
RAPSN receptor-associated protein of the synapse Mapped by LD-proxy TAS[8812503]
CACNB4 calcium channel, voltage-dependent, beta 4 subunit Mapped by PBA pathway
PDE7B phosphodiesterase 7B Mapped by significant region TAS[10814504]
GNG10 guanine nucleotide binding protein (G protein), gamma 10 Mapped by significant region
GRM6 glutamate receptor, metabotropic 6 Mapped by CNV
CACNB2 calcium channel, voltage-dependent, beta 2 subunit Mapped by PBA pathway
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 Mapped by CNV; Mapped by significant region
KCNF1 potassium voltage-gated channel, subfamily F, member 1 Mapped by significant region
DTNA dystrobrevin, alpha Mapped by significant region TAS[8845841]
KCNG4 potassium voltage-gated channel, subfamily G, member 4 Mapped by significant region
RIT2 Ras-like without CAAX 2 Mapped by significant region TAS[8918462]
KCNIP1 Kv channel interacting protein 1 Mapped by LD-proxy; Mapped by literature SNP TAS[10676964]
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) Mapped by PBA pathway ISS[10729324]
ACHE acetylcholinesterase Mapped by PBA pathway
CACNB3 calcium channel, voltage-dependent, beta 3 subunit Mapped by PBA pathway
GLUL glutamate-ammonia ligase Mapped by significant region
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy
HSPA8 heat shock 70kDa protein 8 Mapped by significant region
OMP olfactory marker protein Mapped by significant region TAS[8790421]
KCNJ1 potassium inwardly-rectifying channel, subfamily J, member 1 Mapped by significant region
DOC2A double C2-like domains, alpha Mapped by CNV TAS[7826360]
DLG2 discs, large homolog 2 (Drosophila) Mapped by significant region
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 Mapped by CNV; Mapped by significant region
PRKCB protein kinase C, beta Mapped by significant region
NPY neuropeptide Y Mapped by CNV; Mapped by significant region TAS[10557353]
KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12 Mapped by significant region
GRIA4 glutamate receptor, ionotrophic, AMPA 4 Mapped by significant region
TAAR5 trace amine associated receptor 5 Mapped by significant region TAS[9464258]
SCN2B sodium channel, voltage-gated, type II, beta Mapped by significant region TAS[9295116]
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha Mapped by CNV TAS[8662589]

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014