ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Other Variant Report

Basic Info

Name	DRD4_promoter_-521C/T
Type	point mutation
Location	promoter
Related Gene	DRD4
No. of Study	6 (significant: 0; non-significant 6; trend: 0)

Variant related studies (count: 6)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Mill J, 2003	C/T		TRANSMIT P-value>0.05 TRANSMIT P-value>0.05	no evidence of biased transmission to ADHD probands was foun...... no evidence of biased transmission to ADHD probands was found More...	Non-significant
Kirley A, 2004			allelic TDT P-value=0.33, X²=1.13 in combined sub...... allelic TDT P-value=0.33, X²=1.13 in combined subtype More...	there was no association between this variant and DSM-IV com...... there was no association between this variant and DSM-IV combined type ADHD More...	Non-significant
Lowe N, 2004 (a)	G/A		TDT P-value=0.166, OR=1.25, 95% CI=0.96-1.77 TDT P-value=0.166, OR=1.25, 95% CI=0.96-1.77	insignificant excess of allele A insignificant excess of allele A	Non-significant
Kereszturi E, 2007	C/T			No association was found between ADHD and this SNP No association was found between ADHD and this SNP	Non-significant
Barr CL, 2001(d)	C/T		allelic P-value=0.366, X²=0.818 allelic P-value=0.366, X²=0.818	there was no evidence for biased transmission of the alleles there was no evidence for biased transmission of the alleles	Non-significant
Payton A, 2001	C/T		allelic TDT P-value=0.75 allelic TDT P-value=0.75	there was no evidence of preferential transmission of any ma...... there was no evidence of preferential transmission of any marker allele More...	Non-significant