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KEGG Pathway Report
Basic Info
| ID | hsa02010 |
|---|---|
| Name | ABC transporters |
| Description | The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD). |
| No. of Genes in ADHDgene | 7 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 7)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 7)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | 2q34 | Mapped by significant region |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 | 2q36 | Mapped by significant region |
| ABCG4 | ATP-binding cassette, sub-family G (WHITE), member 4 | 11q23 | Mapped by significant region |
| ABCC6 | ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | 16p13.11 | Mapped by CNV; Mapped by significant region |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 16p13.1 | Mapped by CNV; Mapped by significant region |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 9q31 | Mapped by CNV; Mapped by significant region |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 | 4q22-q23 | Mapped by CNV |