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KEGG Pathway Report
Basic Info
| ID | hsa03450 |
|---|---|
| Name | Non-homologous end-joining |
| Description | Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone. |
| No. of Genes in ADHDgene | 4 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 4)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 4)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MRE11A | MRE11 meiotic recombination 11 homolog A (S. cerevisiae) | 11q21 | Mapped by significant region |
| NHEJ1 | nonhomologous end-joining factor 1 | 2q35 | Mapped by significant region |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 2q35 | Mapped by significant region |
| FEN1 | flap structure-specific endonuclease 1 | 11q12 | Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region |