ADHDgene Database
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  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04020
Name Calcium signaling pathway
Description  Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
No. of Genes in ADHDgene  63
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 63)

Literature-origin genes (count: 23)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
ADRB1 adrenergic, beta-1-, receptor 10q24-q26 2(0/2/0)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0)
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 Xq28 1(0/1/0)
HTR4 5-hydroxytryptamine (serotonin) receptor 4 5q31-q33 1(1/0/0)
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A 13q14-q21 12(6/6/0)
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C Xq24 5(2/3/0)
HTR5A 5-hydroxytryptamine (serotonin) receptor 5A 7q36.1 1(0/1/0)
HTR6 5-hydroxytryptamine (serotonin) receptor 6 1p36-p35 2(0/2/0)
HTR7 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) 10q21-q24 1(0/1/0)
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 3(1/2/0)
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 12p13.3 1(0/1/0)
GRM1 glutamate receptor, metabotropic 1 6q24 1(1/0/0)
NOS1 nitric oxide synthase 1 (neuronal) 12q14-qter 1(1/0/0)
CHRNA7 cholinergic receptor, nicotinic, alpha 7 15q13.3 2(0/1/1)
OXTR oxytocin receptor 3p25 1(0/1/0)
DRD5 dopamine receptor D5 4p16.1 22(14/6/2)
GRM5 glutamate receptor, metabotropic 5 11q14.3 2(1/0/1)
ADRA1D adrenergic, alpha-1D-, receptor 20p13 1(0/1/0)
ADRB2 adrenergic, beta-2-, receptor, surface 5q31-q32 2(1/1/0)
ADRA1A adrenergic, alpha-1A-, receptor 8p21.2 3(2/1/0)
ADRB3 adrenergic, beta-3-, receptor 8p12 2(0/2/0)
ADRA1B adrenergic, alpha-1B-, receptor 5q33.3 2(1/1/0)
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0)

Genes from other sources Help(count: 40)

Approved Symbol Approved Name Location Source
PRKCB protein kinase C, beta 16p12 Mapped by significant region
CCKAR cholecystokinin A receptor 4 Mapped by CNV
PHKG2 phosphorylase kinase, gamma 2 (testis) 16p11.2 Mapped by CNV
CAMK2D calcium/calmodulin-dependent protein kinase II delta 4q26 Mapped by CNV
PLCB2 phospholipase C, beta 2 15q15 Mapped by PBA pathway
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 22q13.1 Mapped by CNV
PLCE1 phospholipase C, epsilon 1 10q23 Mapped by PBA pathway
PLCD1 phospholipase C, delta 1 3p22-p21.3 Mapped by PBA pathway
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit Xp11.23 Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP
P2RX6 purinergic receptor P2X, ligand-gated ion channel, 6 22q11.21 Mapped by CNV
PPP3R2 protein phosphatase 3, regulatory subunit B, beta 9q31 Mapped by significant region
ADORA2A adenosine A2a receptor 22q11.23 Mapped by CNV
PLN phospholamban 6q22.1 Mapped by significant region
RYR1 ryanodine receptor 1 (skeletal) 19q13.1 Mapped by PBA pathway
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 11q13 Mapped by significant region
EDNRA endothelin receptor type A 4 Mapped by PBA pathway
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 16q24.1 Mapped by significant region
ADCY4 adenylate cyclase 4 14q11.2 Mapped by significant region
PLCD4 phospholipase C, delta 4 2q35 Mapped by significant region
LTB4R2 leukotriene B4 receptor 2 14q11.2-q12 Mapped by significant region
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 3p26.1 Mapped by CNV
TRPC1 transient receptor potential cation channel, subfamily C, member 1 3q23 Mapped by PBA pathway
TACR3 tachykinin receptor 3 4q25 Mapped by CNV
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 9q34 Mapped by PBA pathway
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 19p13 Mapped by PBA pathway
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 12p11.23 Mapped by LD-proxy; Mapped by literature SNP
BDKRB2 bradykinin receptor B2 14q32.1-q32.2 Mapped by PBA pathway
CCKBR cholecystokinin B receptor 11p15.4 Mapped by CNV; Mapped by PBA pathway
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 17q22 Mapped by PBA pathway
CHRM3 cholinergic receptor, muscarinic 3 1q41-q44 Mapped by CNV; Mapped by PBA pathway
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 3p14.3 Mapped by PBA pathway
CHRM5 cholinergic receptor, muscarinic 5 15q26 Mapped by CNV; Mapped by PBA pathway
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 17q11.2-q12 Mapped by LD-proxy
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 1q32 Mapped by PBA pathway
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 16p13.3 Mapped by PBA pathway
RYR3 ryanodine receptor 3 15q14-q15 Mapped by CNV; Mapped by PBA pathway
RYR2 ryanodine receptor 2 (cardiac) 1q43 Mapped by CNV; Mapped by PBA pathway
CHRM1 cholinergic receptor, muscarinic 1 11q12-q13 Mapped by PBA pathway; Mapped by significant region
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1q25-q31 Mapped by PBA pathway; Mapped by significant region
P2RX3 purinergic receptor P2X, ligand-gated ion channel, 3 11q12 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014