ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04062
Name Chemokine signaling pathway
Description  Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
No. of Genes in ADHDgene  32
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 32)

Literature-origin genes (count: 6)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
ADRBK2 adrenergic, beta, receptor kinase 2 22q11 1(0/1/0)
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0)
ARRB2 arrestin, beta 2 17p13 1(1/0/0)
TIAM2 T-cell lymphoma invasion and metastasis 2 6q25 1(0/0/1)
ADRBK1 adrenergic, beta, receptor kinase 1 11q13 1(0/1/0)
ARRB1 arrestin, beta 1 11q13 2(1/1/0)

Genes from other sources Help(count: 26)

Approved Symbol Approved Name Location Source
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 11q13 Mapped by significant region
PRKCB protein kinase C, beta 16p12 Mapped by significant region
PLCB2 phospholipase C, beta 2 15q15 Mapped by PBA pathway
CCR5 chemokine (C-C motif) receptor 5 3p21 Mapped by PBA pathway
MAPK1 mitogen-activated protein kinase 1 22q11.2 Mapped by LD-proxy
SHC3 SHC (Src homology 2 domain containing) transforming protein 3 9q22.1 Mapped by significant region
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 11q13 Mapped by significant region
BCAR1 breast cancer anti-estrogen resistance 1 16q22-q23 Mapped by significant region
CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 22q11.21 Mapped by CNV
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2p24 Mapped by significant region
CXCR2 chemokine (C-X-C motif) receptor 2 2q35 Mapped by significant region
CXCR1 chemokine (C-X-C motif) receptor 1 2q35 Mapped by significant region
MAPK3 mitogen-activated protein kinase 3 16p11.2 Mapped by CNV
CXCR5 chemokine (C-X-C motif) receptor 5 11q23.3 Mapped by significant region
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 11q13-q14 Mapped by significant region
WASL Wiskott-Aldrich syndrome-like 7q31.3 Mapped by CNV
GNG3 guanine nucleotide binding protein (G protein), gamma 3 11p11 Mapped by significant region
GNG10 guanine nucleotide binding protein (G protein), gamma 10 9q31.3 Mapped by significant region
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 5q13.1 Mapped by significant region
ITK IL2-inducible T-cell kinase 5q31-q32 Mapped by significant region
CCL27 chemokine (C-C motif) ligand 27 9p13 Mapped by LD-proxy
CCL19 chemokine (C-C motif) ligand 19 9p13 Mapped by LD-proxy
PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide 7q22 Mapped by CNV
CXCL12 chemokine (C-X-C motif) ligand 12 10q11.1 Mapped by PBA pathway
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 11q13 Mapped by significant region
ADCY4 adenylate cyclase 4 14q11.2 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014