ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs10488683 dbSNP Ensembl
Location	Chr11:18053545(Fwd)
Variant Alleles	C/T
Ancestral Allele	T
Functional Annotation	NMD_transcript_variant; intron_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000417164) intron_variant(ENST00000341556; ENST00000250018; ENST00000417164; ENST00000528338)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Johansson S, 2010			logistic regression P-value=0.48, OR=1.07 logistic regression P-value=0.48, OR=1.07	no significant association no significant association	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH1	tryptophan hydroxylase 1	11p15.3-p14	6(2/4/0)

Genes from other sources (count: 0)

SNPs in LD with rs10488683 (count: 19) View in gBrowse (chr11:17935204..18053545 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 19)

rs_ID	Functional Annotation	r²[population]
rs1914710	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.962[CEU]
rs211131	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	0.96[CEU]
rs484616	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.962[CEU]
rs211137	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.959[CEU]
rs2283238	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.962[CEU]; 0.841[TSI]
rs211130	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.961[CEU]; 0.838[TSI]
rs211115	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.96[CEU]
rs12277387	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.962[CEU]; 0.819[TSI]
rs211135	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.962[CEU]; 0.845[GIH]; 0.817[TSI]
rs12292915	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.91[CHB]; 0.837[CHD]; 0.911[GIH]; 0.907[JPT]; 1.0[MEX]; 0.953[TSI]
rs172424	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.962[CEU]; 0.845[GIH]; 0.817[TSI]
rs4757603	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.923[CEU]; 0.8[TSI]
rs371589	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.957[CEU]
rs2237923	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.911[CEU]
rs4757607	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.954[CEU]
rs211114	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.96[CEU]
rs211128	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.962[CEU]
rs2137777	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.962[CEU]
rs2283240	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.962[CEU]; 0.817[TSI]