ADHDgene Database

SNP Report

Basic Info

Name	rs11178999 dbSNP Ensembl
Location	Chr12:72333570(Fwd)
Variant Alleles	G/A
Ancestral Allele	A
Functional Annotation	NMD_transcript_variant; intron_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000546576) intron_variant(ENST00000546576; ENST00000333850)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Johansson S, 2010			logistic regression P-value=0.2, OR=0.87 logistic regression P-value=0.2, OR=0.87	no significant association no significant association	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

SNPs in LD with rs11178999 (count: 7) View in gBrowse (chr12:72329106..72340073 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs6582071	upstream_gene_variant	1(1/0/0)	0.861[CEU]; 1.0[CHB]; 1.0[JPT]
rs4570625	upstream_gene_variant	3(1/2/0)	0.809[ASW]; 0.883[CEU]; 1.0[CHB]; 0.976[CHD]; 1.0[GIH]; 1.0[JPT]; 0.934[LWK]; 0.893[MEX]; 0.972[MKK]; 0.918[TSI]; 0.853[YRI]
rs4448731	upstream_gene_variant	1(0/1/0)	0.866[CHB]; 1.0[JPT]
rs2129575	NMD_transcript_variant; intron_variant	1(0/1/0)	0.883[CEU]; 0.947[MEX]; 0.816[TSI]

rs_ID	Functional Annotation	r²[population]
rs11179000	NMD_transcript_variant; intron_variant	0.878[CEU]; 0.857[CHB]; 0.909[JPT]
rs10748186	NMD_transcript_variant; intron_variant	0.825[CHB]; 1.0[JPT]
rs10748185	NMD_transcript_variant; intron_variant	0.825[CHB]; 1.0[JPT]