ADHDgene Database

SNP Report

Basic Info

Name	rs11757000 dbSNP Ensembl
Location	Chr6:28484869(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000483058) nc_transcript_variant(ENST00000483058) upstream_gene_variant(ENST00000474923; ENST00000361902)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Hinney, A., 2011		T	GWAS P-value=1.17E-05, OR=1.72, Replication FBAT P-value=0.9...... GWAS P-value=1.17E-05, OR=1.72, Replication FBAT P-value=0.9177, Combination P-value=7.63E-05 More...	This GWAS in a small group of clinically ascertained young G...... This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
GPX6	glutathione peroxidase 6 (olfactory)	6p22.1	1(0/1/0)

SNPs in LD with rs11757000 (count: 6) View in gBrowse (chr6:28483150..28667448 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs1319076		1.0[GIH]
rs722788	intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs7738979	intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1.0[GIH]
rs11757235	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[GIH]
rs12111360		1.0[GIH]
rs12110753		1.0[GIH]