ADHDgene Database

SNP Report

Basic Info

Name	rs12453316 dbSNP Ensembl
Location	Chr17:71516059(Fwd)
Variant Alleles	C/T
Ancestral Allele	C
Functional Annotation	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000583547) intron_variant(ENST00000392650; ENST00000388726) nc_transcript_variant(ENST00000583712) non_coding_exon_variant(ENST00000583712)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Lesch KP, 2008			ANOVA P-value=1.72E-05, Mean of ranks=62 ANOVA P-value=1.72E-05, Mean of ranks=62	one of the top 30 single SNPs located in gene regions (inclu...... one of the top 30 single SNPs located in gene regions (including 100kb of flanking sequences) ranked according to the mean rank calculated across three statistics More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SDK2	sidekick homolog 2 (chicken)	17q21.31	1(0/1/0)

SNPs in LD with rs12453316 (count: 3) View in gBrowse (chr17:71512799..71516096 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs12452724	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs17782371	intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.929[GIH]; 1.0[MEX]; 0.882[MKK]; 1.0[TSI]
rs12453319	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]