ADHDgene Database

SNP Report

Basic Info

Name	rs12505502 dbSNP Ensembl
Location	Chr4:91568023(Fwd)
Variant Alleles	T/G
Ancestral Allele	G
Functional Annotation	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000505073; ENST00000513522) downstream_gene_variant(ENST00000502478) intron_variant(ENST00000509176; ENST00000505073; ENST00000432775; ENST00000513522; ENST00000333691) upstream_gene_variant(ENST00000504150; ENST00000509109; ENST00000503421; ENST00000510519)
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Neale BM, 2008	G:T		Uncorrected TDT P-value=6.21E-05 (OR=1.303); Corrected TDT P...... Uncorrected TDT P-value=6.21E-05 (OR=1.303); Corrected TDT P-value=5.62E-05 (OR=1.303) More...	One of top 25 results in both uncorrected and corrected TDT ...... One of top 25 results in both uncorrected and corrected TDT test More...	Non-significant
Lantieri F, 2010	G:T		Binomial P-value=0.05, OR=1.18 for whole sample; Binomial P-...... Binomial P-value=0.05, OR=1.18 for whole sample; Binomial P-value=0.07, OR=1.22 for C-subtype More...	significant in this sample, but not significant after correc...... significant in this sample, but not significant after correction for multiple tests More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
FAM190A	family with sequence similarity 190, member A	4q22.1	1(1/0/0)

SNPs in LD with rs12505502 (count: 8) View in gBrowse (chr4:91566875..91584294 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs4693243	NMD_transcript_variant; intron_variant; upstream_gene_variant	1.0[YRI]
rs1039149	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.822[CEU]
rs10014992	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[YRI]
rs1399408	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.8[CEU]
rs12505430	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.818[CEU]
rs7672803	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	0.876[JPT]
rs17017347	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.822[CEU]
rs1040112	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	0.965[YRI]