ADHDgene Database

SNP Report

Basic Info

Name	rs1555322 dbSNP Ensembl
Location	Chr20:33849179(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000453892; ENST00000438751; ENST00000566203; ENST00000540582; ENST00000454184; ENST00000246186; ENST00000433764; ENST00000456350) nc_transcript_variant(ENST00000453892; ENST00000438751; ENST00000566203; ENST00000454184; ENST00000456350; ENST00000433764)
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Lesch KP, 2008			ANOVA P-value=3.60E-06, Mean of ranks=49 ANOVA P-value=3.60E-06, Mean of ranks=49	one of the top 30 single SNPs located in gene regions (inclu...... one of the top 30 single SNPs located in gene regions (including 100kb of flanking sequences) ranked according to the mean rank calculated across three statistics; annotated by GWAS Catalog More...	Trend

SNP related genes (count: 3)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
MMP24	matrix metallopeptidase 24 (membrane-inserted)	20q11.2	1(0/0/1)

Approved Symbol	Approved Name	Location
EDEM2	ER degradation enhancer, mannosidase alpha-like 2	20q11.22
MMP24-AS1	MMP24 antisense RNA 1	20q11.22

SNPs in LD with rs1555322 (count: 11) View in gBrowse (chr20:33807249..33879206 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs2425027	intron_variant; nc_transcript_variant	0.845[CEU]; 1.0[CHB]; 1.0[JPT]; 0.837[YRI]
rs2425022	intron_variant; nc_transcript_variant	0.812[CEU]; 0.871[TSI]
rs2425032	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.911[CHD]; 1.0[GIH]; 1.0[JPT]; 0.954[TSI]
rs6579227	intron_variant	1.0[CHB]; 0.931[GIH]
rs2425037	downstream_gene_variant; intron_variant; nc_transcript_variant	0.856[CEU]; 1.0[GIH]; 1.0[TSI]
rs2425021	intron_variant; nc_transcript_variant	0.812[CEU]
rs2425046	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CHB]; 0.931[GIH]
rs2425016	downstream_gene_variant; intron_variant; nc_transcript_variant	0.857[CEU]
rs2247828	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.846[JPT]; 1.0[TSI]
rs2425048	5_prime_UTR_variant; downstream_gene_variant; upstream_gene_variant	1.0[CHB]; 0.931[GIH]
rs1205411	downstream_gene_variant; intron_variant; nc_transcript_variant	0.856[CEU]; 1.0[CHB]; 1.0[GIH]; 0.846[JPT]; 1.0[TSI]