ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs1630498 dbSNP Ensembl
Location	Chr11:71150785(Fwd)
Variant Alleles	A/C
Ancestral Allele	A
Functional Annotation	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000525346; ENST00000529990; ENST00000527452; ENST00000531364; ENST00000526780) intron_variant(ENST00000355527; ENST00000407721; ENST00000527316; ENST00000534701; ENST00000524694) nc_transcript_variant(ENST00000534701) upstream_gene_variant(ENST00000533800; ENST00000534795; ENST00000525137)
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Neale BM, 2010 (a)	A:C		P-value=2.77E-05 P-value=2.77E-05	one of top 50 hits from the Genome-Wide Attention-Deficit/Hy...... one of top 50 hits from the Genome-Wide Attention-Deficit/Hyperactivity Disorder (ADHD) meta-analysis More...	Trend

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DHCR7	7-dehydrocholesterol reductase	11q13.4	1(0/0/1)

Genes from other sources (count: 0)

SNPs in LD with rs1630498 (count: 25) View in gBrowse (chr11:71134966..71184190 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 6)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs11603330	downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/0/1)	0.809[CEU]; 0.844[TSI]
rs736894	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/0/1)	1.0[CEU]; 0.865[CHB]; 0.976[CHD]; 0.978[GIH]; 0.909[JPT]; 1.0[MEX]; 1.0[TSI]
rs1790324	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/0/1)	1.0[CEU]; 0.865[CHB]; 0.976[CHD]; 0.978[GIH]; 0.953[JPT]; 1.0[MEX]; 1.0[TSI]
rs7928249	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/0/1)	0.817[TSI]
rs3750997	5_prime_UTR_variant; intron_variant; upstream_gene_variant	1(0/0/1)	0.809[CEU]; 0.872[TSI]
rs12422045	downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/0/1)	0.809[CEU]; 0.844[TSI]

LD-proxies (count: 19)

rs_ID	Functional Annotation	r²[population]
rs1792277	downstream_gene_variant; upstream_gene_variant	1.0[CEU]; 0.95[CHB]; 0.95[JPT]; 0.907[YRI]
rs1792226	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.936[ASW]; 0.89[CEU]; 0.907[CHB]; 1.0[CHD]; 0.955[GIH]; 0.909[JPT]; 0.91[LWK]; 0.868[MKK]; 0.965[TSI]; 1.0[YRI]
rs12419279	downstream_gene_variant; upstream_gene_variant	1.0[CEU]
rs2276362	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.803[CEU]
rs1790345	3_prime_UTR_variant; downstream_gene_variant; intron_variant	0.872[ASW]; 1.0[CEU]; 0.907[CHB]; 0.952[CHD]; 1.0[GIH]; 0.953[JPT]; 0.852[LWK]; 0.893[MEX]; 1.0[MKK]; 1.0[TSI]; 0.921[YRI]
rs12797951	downstream_gene_variant; intron_variant	0.809[CEU]; 0.844[TSI]
rs1790343	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.89[CEU]; 0.942[CHB]; 0.948[JPT]; 1.0[YRI]
rs1792282	downstream_gene_variant; upstream_gene_variant	1.0[CEU]; 0.907[CHB]; 0.927[CHD]; 1.0[GIH]; 0.864[JPT]; 0.893[MEX]; 1.0[TSI]
rs2002064	downstream_gene_variant; intron_variant; upstream_gene_variant	0.936[ASW]; 0.89[CEU]; 0.952[CHB]; 1.0[CHD]; 0.977[GIH]; 0.953[JPT]; 0.977[LWK]; 0.972[MKK]; 0.965[TSI]; 1.0[YRI]
rs1629220	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.936[ASW]; 0.89[CEU]; 0.907[CHB]; 1.0[CHD]; 0.955[GIH]; 0.909[JPT]; 0.91[LWK]; 0.905[MKK]; 0.965[TSI]; 1.0[YRI]
rs1540127	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.882[CEU]; 0.907[CHB]; 0.909[JPT]; 1.0[YRI]
rs4944957	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.817[TSI]
rs1792229	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.936[ASW]; 0.89[CEU]; 0.907[CHB]; 1.0[CHD]; 0.955[GIH]; 0.909[JPT]; 0.91[LWK]; 0.868[MKK]; 0.965[TSI]; 1.0[YRI]
rs12419334	3_prime_UTR_variant	0.838[TSI]
rs11606033	downstream_gene_variant; intron_variant; upstream_gene_variant	0.808[CEU]
rs1792234	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.94[CEU]; 0.897[CHB]; 0.861[JPT]; 1.0[YRI]
rs1792284	downstream_gene_variant; upstream_gene_variant	0.811[ASW]; 1.0[CEU]; 0.903[CHB]; 0.878[CHD]; 0.978[GIH]; 0.908[JPT]; 0.955[LWK]; 0.833[MEX]; 0.986[MKK]; 1.0[TSI]; 0.959[YRI]
rs7935125	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.82[CEU]
rs2282621	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.817[TSI]